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4503. Epidemiology, Etiology, and Treatment of Gastroparesis: Real-World Evidence From a Large US National Claims Database.
作者: Yizhou Ye.;Yu Yin.;Susanna Y Huh.;Cristina Almansa.;Dimitri Bennett.;Michael Camilleri.
来源: Gastroenterology. 2022年162卷1期109-121.e5页
Although gastroparesis carries a considerable health care and patient burden, associated epidemiological data are limited. To provide new real-world evidence for gastroparesis, we estimated disease prevalence, and investigated patient demographics and disease etiology in a large US claims database.
4504. Transferable Immunoglobulin A-Coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation.
作者: Svetlana F Lima.;Lasha Gogokhia.;Monica Viladomiu.;Lance Chou.;Gregory Putzel.;Wen-Bing Jin.;Silvia Pires.;Chun-Jun Guo.;Ylaine Gerardin.;Carl V Crawford.;Vinita Jacob.;Ellen Scherl.;Su-Ellen Brown.;John Hambor.;Randy S Longman.
来源: Gastroenterology. 2022年162卷1期166-178页
Fecal microbiota transplantation (FMT) is an emerging treatment modality for ulcerative colitis (UC). Several randomized controlled trials have shown efficacy for FMT in the treatment of UC, but a better understanding of the transferable microbiota and their immune impact is needed to develop more efficient microbiome-based therapies for UC.
4505. Serologic Response to Coronavirus Disease 2019 (COVID-19) Vaccination in Patients With Immune-Mediated Inflammatory Diseases: A Systematic Review and Meta-analysis.
Patients with immune-mediated inflammatory diseases (IMIDs) have an increased risk of coronavirus disease 2019 (COVID-19), primarily attributed to the use of immunosuppressive drugs such as glucocorticoids, which may attenuate the response to vaccines. This meta-analysis assessed the serologic response to COVID-19 vaccination in patients with IMIDs.
4506. Epithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis.
作者: Lina Welz.;Nassim Kakavand.;Xiang Hang.;Georg Laue.;Go Ito.;Miguel Gomes Silva.;Christina Plattner.;Neha Mishra.;Felicitas Tengen.;Christoph Ogris.;Moritz Jesinghaus.;Felix Wottawa.;Philipp Arnold.;Leena Kaikkonen.;Stefanie Stengel.;Florian Tran.;Saumya Das.;Arthur Kaser.;Zlatko Trajanoski.;Richard Blumberg.;Christoph Roecken.;Dieter Saur.;Markus Tschurtschenthaler.;Stefan Schreiber.;Philip Rosenstiel.;Konrad Aden.
来源: Gastroenterology. 2022年162卷1期223-237.e11页
Throughout life, the intestinal epithelium undergoes constant self-renewal from intestinal stem cells. Together with genotoxic stressors and failing DNA repair, this self-renewal causes susceptibility toward malignant transformation. X-box binding protein 1 (XBP1) is a stress sensor involved in the unfolded protein response (UPR). We hypothesized that XBP1 acts as a signaling hub to regulate epithelial DNA damage responses.
4507. Ulcerative Colitis Patients Have Reduced Rectal Compliance Compared With Non-Inflammatory Bowel Disease Controls.
作者: Noa Krugliak Cleveland.;Victoria Rai.;Katia El Jurdi.;Satish S Rao.;Mihai C Giurcanu.;David T Rubin.
来源: Gastroenterology. 2022年162卷1期331-333.e1页 4510. Epithelium Replacement Contributes to Field Expansion of Squamous Epithelium and Ulcerative Colitis-Associated Neoplasia.
作者: Shinya Sugimoto.;Yasushi Iwao.;Masayuki Shimoda.;Kaoru Takabayashi.;Toshiro Sato.;Takanori Kanai.; .
来源: Gastroenterology. 2022年162卷1期334-337.e5页 4511. Underrepresentation of Minorities and Underreporting of Race and Ethnicity in Crohn's Disease Clinical Trials.
作者: Rocio Sedano.;Malcolm Hogan.;Cassandra Mcdonald.;Tina Aswani-Omprakash.;Christopher Ma.;Vipul Jairath.
来源: Gastroenterology. 2022年162卷1期338-340.e2页 4517. An Enhancer-Driven Stem Cell-Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer.
作者: Xiaoyan Liang.;Gina N Duronio.;Yaying Yang.;Pratyusha Bala.;Prajna Hebbar.;Sandor Spisak.;Pranshu Sahgal.;Harshabad Singh.;Yanxi Zhang.;Yingtian Xie.;Paloma Cejas.;Henry W Long.;Adam J Bass.;Nilay S Sethi.
来源: Gastroenterology. 2022年162卷1期209-222页
Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular mediators that promote these malignant properties require further elucidation to galvanize translational advances. We therefore aimed to characterize a key factor that blocks intestinal differentiation, define its transcriptional and epigenetic program, and provide preclinical evidence for therapeutic targeting in CRC.
4518. Global Incidence of Acute Pancreatitis Is Increasing Over Time: A Systematic Review and Meta-Analysis.
作者: Jordan P Iannuzzi.;James A King.;Jessica Hope Leong.;Joshua Quan.;Joseph W Windsor.;Divine Tanyingoh.;Stephanie Coward.;Nauzer Forbes.;Steven J Heitman.;Abdel-Aziz Shaheen.;Mark Swain.;Michael Buie.;Fox E Underwood.;Gilaad G Kaplan.
来源: Gastroenterology. 2022年162卷1期122-134页
Acute pancreatitis is a common disease with significant associated morbidity and mortality. We performed a systematic review and meta-analysis of population-based studies to explore the changing temporal trends of acute pancreatitis incidence globally.
4520. Ongoing Global Impact of the COVID-19 Pandemic on Endoscopy: A Subsequent International Survey of 121 Centers From 35 Countries.
作者: Sachin Srinivasan.;Suneha Sundaram.;Fabian Emura.;Nageshwar Reddy.;Douglas O Faigel.;Alessandro Repici.;Sravanthi Parasa.;Prateek Sharma.
来源: Gastroenterology. 2022年162卷1期328-330.e3页 |