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4510. Overall Survival with Ribociclib plus Letrozole in Advanced Breast Cancer.
作者: Gabriel N Hortobagyi.;Salomon M Stemmer.;Howard A Burris.;Yoon-Sim Yap.;Gabe S Sonke.;Lowell Hart.;Mario Campone.;Katarina Petrakova.;Eric P Winer.;Wolfgang Janni.;Pierfranco Conte.;David A Cameron.;Fabrice André.;Carlos L Arteaga.;Juan P Zarate.;Arunava Chakravartty.;Tetiana Taran.;Fabienne Le Gac.;Paolo Serra.;Joyce O'Shaughnessy.
来源: N Engl J Med. 2022年386卷10期942-950页
In a previous analysis of this phase 3 trial, first-line ribociclib plus letrozole resulted in significantly longer progression-free survival than letrozole alone among postmenopausal patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer. Whether overall survival would also be longer with ribociclib was not known.
4511. Thyroidectomy without Radioiodine in Patients with Low-Risk Thyroid Cancer.
作者: Sophie Leboulleux.;Claire Bournaud.;Cecile N Chougnet.;Slimane Zerdoud.;Abir Al Ghuzlan.;Bogdan Catargi.;Christine Do Cao.;Antony Kelly.;Marie-Luce Barge.;Ludovic Lacroix.;Inna Dygai.;Pierre Vera.;Daniela Rusu.;Olivier Schneegans.;Danielle Benisvy.;Marc Klein.;Julie Roux.;Marie-Claude Eberle.;Delphine Bastie.;Camila Nascimento.;Anne-Laure Giraudet.;Nathalie Le Moullec.;Stéphane Bardet.;Delphine Drui.;Nathalie Roudaut.;Yann Godbert.;Olivier Morel.;Anne Drutel.;Livia Lamartina.;Claire Schvartz.;Fritz-Line Velayoudom.;Martin-Jean Schlumberger.;Laurence Leenhardt.;Isabelle Borget.
来源: N Engl J Med. 2022年386卷10期923-932页
In patients with low-risk differentiated thyroid cancer undergoing thyroidectomy, the postoperative administration of radioiodine (iodine-131) is controversial in the absence of demonstrated benefits.
4512. Shorter Treatment for Nonsevere Tuberculosis in African and Indian Children.
作者: Anna Turkova.;Genevieve H Wills.;Eric Wobudeya.;Chishala Chabala.;Megan Palmer.;Aarti Kinikar.;Syed Hissar.;Louise Choo.;Philippa Musoke.;Veronica Mulenga.;Vidya Mave.;Bency Joseph.;Kristen LeBeau.;Margaret J Thomason.;Robert B Mboizi.;Monica Kapasa.;Marieke M van der Zalm.;Priyanka Raichur.;Perumal K Bhavani.;Helen McIlleron.;Anne-Marie Demers.;Rob Aarnoutse.;James Love-Koh.;James A Seddon.;Steven B Welch.;Stephen M Graham.;Anneke C Hesseling.;Diana M Gibb.;Angela M Crook.; .
来源: N Engl J Med. 2022年386卷10期911-922页
Two thirds of children with tuberculosis have nonsevere disease, which may be treatable with a shorter regimen than the current 6-month regimen.
4514. Resistance Mutations in SARS-CoV-2 Delta Variant after Sotrovimab Use.
作者: Rebecca Rockett.;Kerri Basile.;Susan Maddocks.;Winkie Fong.;Jessica E Agius.;Jessica Johnson-Mackinnon.;Alicia Arnott.;Shona Chandra.;Mailie Gall.;Jenny Draper.;Elena Martinez.;Eby M Sim.;Clement Lee.;Christine Ngo.;Marc Ramsperger.;Andrew N Ginn.;Qinning Wang.;Michael Fennell.;Danny Ko.;H Ling Lim.;Nicky Gilroy.;Matthew V N O'Sullivan.;Sharon C-A Chen.;Jen Kok.;Dominic E Dwyer.;Vitali Sintchenko.
来源: N Engl J Med. 2022年386卷15期1477-1479页 4515. Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant.
作者: Nick Andrews.;Julia Stowe.;Freja Kirsebom.;Samuel Toffa.;Tim Rickeard.;Eileen Gallagher.;Charlotte Gower.;Meaghan Kall.;Natalie Groves.;Anne-Marie O'Connell.;David Simons.;Paula B Blomquist.;Asad Zaidi.;Sophie Nash.;Nurin Iwani Binti Abdul Aziz.;Simon Thelwall.;Gavin Dabrera.;Richard Myers.;Gayatri Amirthalingam.;Saheer Gharbia.;Jeffrey C Barrett.;Richard Elson.;Shamez N Ladhani.;Neil Ferguson.;Maria Zambon.;Colin N J Campbell.;Kevin Brown.;Susan Hopkins.;Meera Chand.;Mary Ramsay.;Jamie Lopez Bernal.
来源: N Engl J Med. 2022年386卷16期1532-1546页
A rapid increase in coronavirus disease 2019 (Covid-19) cases due to the omicron (B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 in highly vaccinated populations has aroused concerns about the effectiveness of current vaccines.
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