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4481. MicroRNA-15a/16-1 Prevents Hepatocellular Carcinoma by Disrupting the Communication Between Kupffer Cells and Regulatory T Cells.
作者: Ningning Liu.;Ching Wen Chang.;Clifford J Steer.;Xin Wei Wang.;Guisheng Song.
来源: Gastroenterology. 2022年162卷2期575-589页
Hepatocellular carcinoma (HCC) is characterized by intratumoral accumulation of regulatory T cells (Tregs), which suppresses antitumor immunity. This study was designed to investigate how microRNAs regulate immunosuppression in HCC.
4483. Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2021.
作者: Anne F Peery.;Seth D Crockett.;Caitlin C Murphy.;Elizabeth T Jensen.;Hannah P Kim.;Matthew D Egberg.;Jennifer L Lund.;Andrew M Moon.;Virginia Pate.;Edward L Barnes.;Courtney L Schlusser.;Todd H Baron.;Nicholas J Shaheen.;Robert S Sandler.
来源: Gastroenterology. 2022年162卷2期621-644页
Gastrointestinal diseases account for considerable health care use and expenditures. We estimated the annual burden, costs, and research funding associated with gastrointestinal, liver, and pancreatic diseases in the United States.
4486. American Gastroenterological Association Institute and College of American Pathologists Quality Measure Development for Detection of Mismatch Repair Deficiency and Lynch Syndrome Management.
作者: David A Leiman.;Diana M Cardona.;Sonia S Kupfer.;Jonathan Rosenberg.;Gregary T Bocsi.;Heather Hampel.; .
来源: Gastroenterology. 2022年162卷2期360-365页 4491. An Antigenically Diverse, Representative Panel of Envelope Glycoproteins for Hepatitis C Virus Vaccine Development.
作者: Jordan H Salas.;Richard A Urbanowicz.;Johnathan D Guest.;Nicole Frumento.;Alexis Figueroa.;Kaitlyn E Clark.;Zhenyong Keck.;Vanessa M Cowton.;Sarah J Cole.;Arvind H Patel.;Thomas R Fuerst.;Heidi E Drummer.;Marian Major.;Alexander W Tarr.;Jonathan K Ball.;Mansun Law.;Brian G Pierce.;Steven K H Foung.;Justin R Bailey.
来源: Gastroenterology. 2022年162卷2期562-574页
Development of a prophylactic hepatitis C virus (HCV) vaccine will require accurate and reproducible measurement of neutralizing breadth of vaccine-induced antibodies. Currently available HCV panels may not adequately represent the genetic and antigenic diversity of circulating HCV strains, and the lack of standardization of these panels makes it difficult to compare neutralization results obtained in different studies. Here, we describe the selection and validation of a genetically and antigenically diverse reference panel of 15 HCV pseudoparticles (HCVpps) for neutralization assays.
4495. A Microsatellite in the Coding Sequence of HLA-A/B Is a Mutation Hotspot in Colon Cancer With Microsatellite Instability.
作者: William J Raab.;Arabella Mazzocchi.;Paolo Radice.;Debashis Sahoo.;Chiara Castelli.;Piero Dalerba.; .
来源: Gastroenterology. 2022年162卷3期960-963.e3页 4496. Changes in Metabolic Syndrome Status are Associated With Altered Risk of Pancreatic Cancer: A Nationwide Cohort Study.
作者: Joo-Hyun Park.;Kyungdo Han.;Jung Yong Hong.;Young Suk Park.;Kyu Yeon Hur.;Gunseog Kang.;Joon Oh Park.
来源: Gastroenterology. 2022年162卷2期509-520.e7页
Metabolic syndrome (MetS) is reversible; however, the effect of changes in MetS status on pancreatic cancer risk is unknown. We aimed to investigate the effects of changes and persistence in MetS status on pancreatic cancer risk.
4497. Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma via Autophagy Inhibition, MEK Blockade, and CD40 Agonism.
作者: Honglin Jiang.;Tristan Courau.;Joseph Borison.;Alexa J Ritchie.;Aaron T Mayer.;Matthew F Krummel.;Eric A Collisson.
来源: Gastroenterology. 2022年162卷2期590-603.e14页
Patients with pancreatic ductal adenocarcinoma (PDA) have not yet benefitted from the revolution in cancer immunotherapy due in large part to a dominantly immunosuppressive tumor microenvironment. MEK inhibition combined with autophagy inhibition leads to transient tumor responses in some patients with PDA. We examined the functional effects of combined MEK and autophagy inhibition on the PDA immune microenvironment and the synergy of combined inhibition of MEK and autophagy with CD40 agonism (aCD40) against PDA using immunocompetent model systems.
4498. Incidence and Mortality in Upper Gastrointestinal Cancer After Negative Endoscopy for Gastroesophageal Reflux Disease.
作者: Dag Holmberg.;Giola Santoni.;My Catarina von Euler-Chelpin.;Martti Färkkilä.;Joonas H Kauppila.;John Maret-Ouda.;Eivind Ness-Jensen.;Jesper Lagergren.
来源: Gastroenterology. 2022年162卷2期431-438.e4页
Gastroesophageal reflux disease (GERD) is associated with an increased risk of cancer of the upper gastrointestinal tract. This study aimed to assess whether and to what extent a negative upper endoscopy in patients with GERD is associated with decreased incidence and mortality in upper gastrointestinal cancer (ie, esophageal, gastric, or duodenal cancer).
4499. Host-Microbiota Interactions in the Esophagus During Homeostasis and Allergic Inflammation.
作者: Michael Brusilovsky.;Riyue Bao.;Mark Rochman.;Andrea M Kemter.;Cathryn R Nagler.;Marc E Rothenberg.
来源: Gastroenterology. 2022年162卷2期521-534.e8页
Microbiota composition and mechanisms of host-microbiota interactions in the esophagus are unclear. We aimed to uncover fundamental information about the esophageal microbiome and its potential significance to eosinophilic esophagitis (EoE).
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