4488. Capsid Inhibition with Lenacapavir in Multidrug-Resistant HIV-1 Infection.
作者: Sorana Segal-Maurer.;Edwin DeJesus.;Hans-Jurgen Stellbrink.;Antonella Castagna.;Gary J Richmond.;Gary I Sinclair.;Krittaecho Siripassorn.;Peter J Ruane.;Mezgebe Berhe.;Hui Wang.;Nicolas A Margot.;Hadas Dvory-Sobol.;Robert H Hyland.;Diana M Brainard.;Martin S Rhee.;Jared M Baeten.;Jean-Michel Molina.; .
来源: N Engl J Med. 2022年386卷19期1793-1803页
Patients with multidrug-resistant human immunodeficiency virus type 1 (HIV-1) infection have limited treatment options. Lenacapavir is a first-in-class capsid inhibitor that showed substantial antiviral activity in a phase 1b study.
4490. Evaluation of mRNA-1273 Covid-19 Vaccine in Children 6 to 11 Years of Age.
作者: C Buddy Creech.;Evan Anderson.;Vladimir Berthaud.;Inci Yildirim.;Andrew M Atz.;Ivan Melendez Baez.;Daniel Finkelstein.;Paul Pickrell.;Judith Kirstein.;Clifford Yut.;Ronald Blair.;Robert A Clifford.;Michael Dunn.;James D Campbell.;David C Montefiori.;Joanne E Tomassini.;Xiaoping Zhao.;Weiping Deng.;Honghong Zhou.;Daniela Ramirez Schrempp.;Kelly Hautzinger.;Bethany Girard.;Karen Slobod.;Roderick McPhee.;Rolando Pajon.;Rituparna Das.;Jacqueline M Miller.;Sabine Schnyder Ghamloush.; .
来源: N Engl J Med. 2022年386卷21期2011-2023页
Vaccination of children to prevent coronavirus disease 2019 (Covid-19) is an urgent public health need. The safety, immunogenicity, and efficacy of the mRNA-1273 vaccine in children 6 to 11 years of age are unknown.
4499. Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine.
作者: Karen J Hager.;Gonzalo Pérez Marc.;Philipe Gobeil.;Ricardo S Diaz.;Gretchen Heizer.;Conrado Llapur.;Alexander I Makarkov.;Eduardo Vasconcellos.;Stéphane Pillet.;Fernando Riera.;Pooja Saxena.;Priscila Geller Wolff.;Kapil Bhutada.;Garry Wallace.;Hessam Aazami.;Christine E Jones.;Fernando P Polack.;Luciana Ferrara.;Judith Atkins.;Iohann Boulay.;Jiwanjeet Dhaliwall.;Nathalie Charland.;Manon M J Couture.;Julia Jiang-Wright.;Nathalie Landry.;Sophie Lapointe.;Aurélien Lorin.;Asif Mahmood.;Lawrence H Moulton.;Emmy Pahmer.;Julie Parent.;Annie Séguin.;Luan Tran.;Thomas Breuer.;Maria-Angeles Ceregido.;Marguerite Koutsoukos.;François Roman.;Junya Namba.;Marc-André D'Aoust.;Sonia Trepanier.;Yosuke Kimura.;Brian J Ward.; .
来源: N Engl J Med. 2022年386卷22期2084-2096页
Coronavirus-like particles (CoVLP) that are produced in plants and display the prefusion spike glycoprotein of the original strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are combined with an adjuvant (Adjuvant System 03 [AS03]) to form the candidate vaccine.
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