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4461. Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury.
作者: Zhibo Ma.;Nikki K Lytle.;Bob Chen.;Nidhi Jyotsana.;Sammy Weiser Novak.;Charles J Cho.;Leah Caplan.;Olivia Ben-Levy.;Abigail C Neininger.;Dylan T Burnette.;Vincent Q Trinh.;Marcus C B Tan.;Emilee A Patterson.;Rafael Arrojo E Drigo.;Rajshekhar R Giraddi.;Cynthia Ramos.;Anna L Means.;Ichiro Matsumoto.;Uri Manor.;Jason C Mills.;James R Goldenring.;Ken S Lau.;Geoffrey M Wahl.;Kathleen E DelGiorno.
来源: Gastroenterology. 2022年162卷2期604-620.e20页
Acinar to ductal metaplasia (ADM) occurs in the pancreas in response to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies was to define the populations arising from ADM, the associated transcriptional changes, and markers of disease progression.
4462. Observation on clinical application effect of psychological nursing intervention in nursing care of elderly patients with chronic gastritis and analysis of nursing satisfaction.
作者: Xiuling Yang.;Yinhua Chen.;Sijie Chen.;Lin Pan.
来源: Minerva Gastroenterol (Torino). 2022年68卷2期251-253页 4467. Specialized Mechanosensory Epithelial Cells in Mouse Gut Intrinsic Tactile Sensitivity.
作者: Anthony J Treichel.;Isabelle Finholm.;Kaitlyn R Knutson.;Constanza Alcaino.;Sara T Whiteman.;Matthew R Brown.;Aleksey Matveyenko.;Andrew Wegner.;Halil Kacmaz.;Arnaldo Mercado-Perez.;Gabriella Bedekovicsne Gajdos.;Tamas Ordog.;Madhusudan Grover.;Joseph Szurszewski.;David R Linden.;Gianrico Farrugia.;Arthur Beyder.
来源: Gastroenterology. 2022年162卷2期535-547.e13页
The gastrointestinal (GI) tract extracts nutrients from ingested meals while protecting the organism from infectious agents frequently present in meals. Consequently, most animals conduct the entire digestive process within the GI tract while keeping the luminal contents entirely outside the body, separated by the tightly sealed GI epithelium. Therefore, like the skin and oral cavity, the GI tract must sense the chemical and physical properties of the its external interface to optimize its function. Specialized sensory enteroendocrine cells (EECs) in GI epithelium interact intimately with luminal contents. A subpopulation of EECs express the mechanically gated ion channel Piezo2 and are developmentally and functionally like the skin's touch sensor- the Merkel cell. We hypothesized that Piezo2+ EECs endow the gut with intrinsic tactile sensitivity.
4475. HLA Class I Analysis Provides Insight Into the Genetic and Epigenetic Background of Immune Evasion in Colorectal Cancer With High Microsatellite Instability.
作者: Masahito Kawazu.;Toshihide Ueno.;Koichi Saeki.;Nicolas Sax.;Yosuke Togashi.;Takayuki Kanaseki.;Keigo Chida.;Fumishi Kishigami.;Kazuhito Sato.;Shinya Kojima.;Masafumi Otsuka.;Akihito Kawazoe.;Hitomi Nishinakamura.;Maeda Yuka.;Yoko Yamamoto.;Kazuo Yamashita.;Satoshi Inoue.;Tokiyoshi Tanegashima.;Daisuke Matsubara.;Kenta Tane.;Yosuke Tanaka.;Hisae Iinuma.;Yojiro Hashiguchi.;Shoichi Hazama.;Seik-Soon Khor.;Katsushi Tokunaga.;Masahiro Tsuboi.;Toshiro Niki.;Masatoshi Eto.;Kohei Shitara.;Toshihiko Torigoe.;Soichiro Ishihara.;Hiroyuki Aburatani.;Hiroshi Haeno.;Hiroyoshi Nishikawa.;Hiroyuki Mano.
来源: Gastroenterology. 2022年162卷3期799-812页
A detailed understanding of antitumor immunity is essential for optimal cancer immune therapy. Although defective mutations in the B2M and HLA-ABC genes, which encode molecules essential for antigen presentation, have been reported in several studies, the effects of these defects on tumor immunity have not been quantitatively evaluated.
4476. Prolonged Impairment of Short-Chain Fatty Acid and L-Isoleucine Biosynthesis in Gut Microbiome in Patients With COVID-19.
作者: Fen Zhang.;Yating Wan.;Tao Zuo.;Yun Kit Yeoh.;Qin Liu.;Lin Zhang.;Hui Zhan.;Wenqi Lu.;Wenye Xu.;Grace C Y Lui.;Amy Y L Li.;Chun Pan Cheung.;Chun Kwok Wong.;Paul K S Chan.;Francis K L Chan.;Siew C Ng.
来源: Gastroenterology. 2022年162卷2期548-561.e4页
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with altered gut microbiota composition. Phylogenetic groups of gut bacteria involved in the metabolism of short chain fatty acids (SCFAs) were depleted in SARS-CoV-2-infected patients. We aimed to characterize a functional profile of the gut microbiome in patients with COVID-19 before and after disease resolution.
4477. Comparing Colorectal Cancer Screening Outcomes in the International Cancer Screening Network: A Consortium Proposal.
作者: Nereo Segnan.;Evelien Dekker.;V Paul Doria-Rose.;Carlo Senore.;Linda Rabeneck.;Iris Lansdorp-Vogelaar.; .
来源: Gastroenterology. 2022年162卷3期668-674页 4479. Loss of Endothelial TSPAN12 Promotes Fibrostenotic Eosinophilic Esophagitis via Endothelial Cell-Fibroblast Crosstalk.
作者: Tetsuo Shoda.;Ting Wen.;Julie M Caldwell.;Netali Ben-Baruch Morgenstern.;Garrett A Osswald.;Mark Rochman.;Lydia E Mack.;Jennifer M Felton.;J Pablo Abonia.;Nicoleta C Arva.;Dan Atkins.;Peter A Bonis.;Kelley E Capocelli.;Margaret H Collins.;Evan S Dellon.;Gary W Falk.;Nirmala Gonsalves.;Sandeep K Gupta.;Ikuo Hirano.;John Leung.;Paul A Menard-Katcher.;Vincent A Mukkada.;Philip E Putnam.;Amanda K Rudman Spergel.;Jonathan M Spergel.;Joshua B Wechsler.;Guang-Yu Yang.;Seema S Aceves.;Glenn T Furuta.;Marc E Rothenberg.; .
来源: Gastroenterology. 2022年162卷2期439-453页
Eosinophilic esophagitis (EoE) can progress to fibrostenosis by unclear mechanisms. Herein, we investigated gene dysregulation in fibrostenotic EoE, its association with clinical parameters and specific pathways, and the functional consequences.
4480. Timeline of Development of Pancreatic Cancer and Implications for Successful Early Detection in High-Risk Individuals.
作者: Kasper A Overbeek.;Michael G Goggins.;Mohamad Dbouk.;Iris J M Levink.;Brechtje D M Koopmann.;Miguel Chuidian.;Ingrid C A W Konings.;Salvatore Paiella.;Julie Earl.;Paul Fockens.;Thomas M Gress.;Margreet G E M Ausems.;Jan-Werner Poley.;Nirav C Thosani.;Elizabeth Half.;Jesse Lachter.;Elena M Stoffel.;Richard S Kwon.;Alina Stoita.;Fay Kastrinos.;Aimee L Lucas.;Sapna Syngal.;Randall E Brand.;Amitabh Chak.;Alfredo Carrato.;Frank P Vleggaar.;Detlef K Bartsch.;Jeanin E van Hooft.;Djuna L Cahen.;Marcia Irene Canto.;Marco J Bruno.; .
来源: Gastroenterology. 2022年162卷3期772-785.e4页
To successfully implement imaging-based pancreatic cancer (PC) surveillance, understanding the timeline and morphologic features of neoplastic progression is key. We aimed to investigate the progression to neoplasia from serial prediagnostic pancreatic imaging tests in high-risk individuals and identify factors associated with successful early detection.
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