4472. Human Infection with an Avian-Origin Influenza A (H10N3) Virus.
作者: Xian Qi.;Haibo Qiu.;Shixuan Hao.;Fengcai Zhu.;Yingzi Huang.;Ke Xu.;Huiyan Yu.;Daowei Wang.;Lei Zhou.;Qigang Dai.;Yin Zhou.;Shenjiao Wang.;Haodi Huang.;Shuyue Yu.;Xiang Huo.;Kai Chen.;Jin Liu.;Jianli Hu.;Ming Wu.;Changjun Bao.
来源: N Engl J Med. 2022年386卷11期1087-1088页 4479. Phase 2 Trial of Iberdomide in Systemic Lupus Erythematosus.
作者: Joan T Merrill.;Victoria P Werth.;Richard Furie.;Ronald van Vollenhoven.;Thomas Dörner.;Milan Petronijevic.;Jorge Velasco.;Maria Majdan.;Fedra Irazoque-Palazuelos.;Michael Weiswasser.;Shimon Korish.;Ying Ye.;Allison Gaudy.;Peter H Schafer.;Zhaohui Liu.;Nataliya Agafonova.;Nikolay Delev.
来源: N Engl J Med. 2022年386卷11期1034-1045页
Iberdomide, a cereblon modulator promoting degradation of the transcription factors Ikaros and Aiolos, which affect leukocyte development and autoimmunity, is being evaluated for the treatment of systemic lupus erythematosus (SLE).
4480. Inhibition of Prekallikrein for Hereditary Angioedema.
作者: Lauré M Fijen.;Marc A Riedl.;Laura Bordone.;Jonathan A Bernstein.;Jason Raasch.;Raffi Tachdjian.;Timothy Craig.;William R Lumry.;Michael E Manning.;Veronica J Alexander.;Kenneth B Newman.;Alexey Revenko.;Brenda F Baker.;Charvi Nanavati.;A Robert MacLeod.;Eugene Schneider.;Danny M Cohn.
来源: N Engl J Med. 2022年386卷11期1026-1033页
Hereditary angioedema is characterized by recurrent and unpredictable swellings that are disabling and potentially fatal. Selective inhibition of plasma prekallikrein production by antisense oligonucleotide treatment (donidalorsen) may reduce the frequency of attacks and the burden of disease.
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