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4441. 'Non-criteria antiphospholipid antibodies': bridging the gap between seropositive and seronegative antiphospholipid syndrome.
作者: Simona Truglia.;Silvia Mancuso.;Antonella Capozzi.;Serena Recalchi.;Gloria Riitano.;Agostina Longo.;Sara De Carolis.;Francesca Romana Spinelli.;Cristiano Alessandri.;Fulvia Ceccarelli.;Caterina De Carolis.;Roberta Misasi.;Maurizio Sorice.;Fabrizio Conti.
来源: Rheumatology (Oxford). 2022年61卷2期826-833页
We aimed to analyse the prevalence of non-criteria anti-phospholipid (aPL) antibodies and their role in the diagnosis, treatment and prognosis in a cohort of patients with clinical features consistent with a diagnosis of antiphospholipid syndrome (APS), but persistently negative for criteria aPL - anti-cardiolipin antibodies (aCL), anti-β2-glycoprotein I antibodies (aβ2-GPI) and lupus anticoagulant (LA) - named seronegative APS (SN-APS).
4442. Abdominal arterial lesions associated with antiphospholipid antibodies: a comparative cross-sectional magnetic resonance angiography study.
作者: Shirish R Sangle.;Wajanat Jan.;Hosam E Matar.;Sheila Rankin.;David P D'Cruz.
来源: Rheumatology (Oxford). 2022年61卷2期658-666页
Case reports and small case series suggest that stenotic lesions of the renal, coeliac and mesenteric arteries may occur in the antiphospholipid syndrome (APS) resulting in clinical consequences such as hypertension and abdominal angina. The objective was to determine the prevalence of stenotic lesions in arteries arising from the middle aorta in patients with antiphospholipid antibodies (aPL) compared with healthy, hypertensive and atherosclerotic controls.
4443. The synergistic efficacy of hydroxychloroquine with methotrexate is accompanied by increased erythrocyte mean corpuscular volume.
作者: Muhammad Ruhul Amin Shipa.;Su-Ann Yeoh.;Andrew Embleton-Thirsk.;Dev Mukerjee.;Michael R Ehrenstein.
来源: Rheumatology (Oxford). 2022年61卷2期787-793页
To determine whether concomitant HCQ modulates the increase in erythrocyte mean corpuscular volume (MCV) caused by MTX therapy, and whether this is associated with improved clinical response in RA.
4444. The association between increased body mass index and response to conventional synthetic disease-modifying anti-rheumatic drug treatment in rheumatoid arthritis: results from the METEOR database.
作者: Mrinalini Dey.;Sizheng S Zhao.;Robert J Moots.;Sytske Anne Bergstra.;Robert B Landewe.;Nicola J Goodson.
来源: Rheumatology (Oxford). 2022年61卷2期713-722页
Few data exist on the association between increased BMI and response to conventional synthetic DMARDs (csDMARDs) in RA. We aimed to explore the association between increased (overweight or obese) BMI on csDMARD prescribing, MTX dose and disease activity over 12 months.
4445. The role of PD-1/PD-Ls in the pathogenesis of IgG4-related disease.
作者: Xia Zhang.;Hui Lu.;Linyi Peng.;Jiaxin Zhou.;Mu Wang.;Jieqiong Li.;Zheng Liu.;Wen Zhang.;Yan Zhao.;Xiaofeng Zeng.;Liwei Lu.
来源: Rheumatology (Oxford). 2022年61卷2期815-825页
To investigate the role of programmed cell death protein 1 (PD-1) and its two ligands, PD-L1 and PD-L2, in the pathogenesis of IgG4-related disease (IgG4-RD).
4446. Immunosuppressive therapy withdrawal after remission achievement in patients with lupus nephritis.
作者: Margherita Zen.;Enrico Fuzzi.;Marta Loredo Martinez.;Roberto Depascale.;Micaela Fredi.;Mariele Gatto.;Maddalena Larosa.;Francesca Saccon.;Luca Iaccarino.;Andrea Doria.
来源: Rheumatology (Oxford). 2022年61卷2期688-695页
Whether immunosuppressive therapy may be safely withdrawn in lupus nephritis (LN) is still unclear. We assessed rate and predictors of flare after IS withdrawal in patients with LN in remission.
4447. Autoantibody predictors of gastrointestinal symptoms in systemic sclerosis.
作者: Fiza Ahmed.;Rory H Maclean.;Svetlana I Nihtyanova.;Voon H Ong.;Charles D Murray.;Christopher P Denton.
来源: Rheumatology (Oxford). 2022年61卷2期781-786页
To assess the prevalence and burden of SSc-related gastrointestinal dysfunction (SSc-GI) and to evaluate associations with demographic, clinical and serological characteristics.
4448. The challenge of early diagnosis of autoimmune lymphoproliferative syndrome in children with suspected autoinflammatory/autoimmune disorders.
作者: Leonardo Oliveira Mendonça.;Caterina Matucci-Cerinic.;Paola Terranova.;Federica Casabona.;Francesca Bovis.;Roberta Caorsi.;Francesca Fioredda.;Elena Palmisani.;Alice Grossi.;Daniela Guardo.;Marta Bustaffa.;Stefano Volpi.;Isabella Ceccherini.;Angelo Ravelli.;Carlo Dufour.;Maurizio Miano.;Marco Gattorno.
来源: Rheumatology (Oxford). 2022年61卷2期696-704页
To test the usefulness of an extended panel of lymphocyte subsets in combination with Oliveira's diagnostic criteria for the identification of autoimmune lymphoproliferative syndrome (ALPS) in children referred to a paediatric rheumatology centre.
4449. Identifying parameters associated with delayed diagnosis in axial spondyloarthritis: data from the European map of axial spondyloarthritis.
作者: Marco Garrido-Cumbrera.;Victoria Navarro-Compán.;Christine Bundy.;Raj Mahapatra.;Souzi Makri.;José Correa-Fernández.;Laura Christen.;Carlos Jesús Delgado-Domínguez.;Denis Poddubnyy.; .
来源: Rheumatology (Oxford). 2022年61卷2期705-712页
To identify the parameters associated with self-reported diagnostic delay (DD) in axial spondyloarthritis (axSpA) patients across Europe.
4450. Root joint involvement in spondyloarthritis: a post hoc analysis from the international ASAS-PerSpA study.
作者: Nelly Ziadé.;Jean El Hajj.;Joe Rassi.;Sani Hlais.;Clementina López-Medina.;Sherif M Gamal.;Bassel Elzorkany.;Maxime Dougados.;Xenofon Baraliakos.
来源: Rheumatology (Oxford). 2022年61卷2期667-678页
The primary objective was to compare the clinical characteristics of SpA patients with and without root joint disease (RJD+ and RJD-). The secondary objectives were to compare the prevalence of RJD across various SpA subtypes and in different world regions, and to compare the SpA axial severity and SpA burden between RJD+ and RJD-.
4451. Clinical and biomechanical factors associated with falls and rheumatoid arthritis: baseline cohort with longitudinal nested case-control study.
作者: Toby O Smith.;Celia Clarke.;Jack R Dainty.;Laura Watts.;Max Yates.;Valerie M Pomeroy.;Emma Stanmore.;Terence W O'Neill.;Alexander J Macgregor.
来源: Rheumatology (Oxford). 2022年61卷2期679-687页
To identify the clinical and biomechanical characteristics associated with falls in people with RA.
4453. Towards sex-specific osteoarthritis risk models: evaluation of risk factors for knee osteoarthritis in males and females.
作者: Ingrid A Szilagyi.;Jan H Waarsing.;Dieuwke Schiphof.;Joyce B J van Meurs.;Sita M A Bierma-Zeinstra.
来源: Rheumatology (Oxford). 2022年61卷2期648-657页
The aim of this study was to identify sex-specific prevalence and strength of risk factors for the incidence of radiographic knee OA (incRKOA).
4454. Do tender joints in active psoriatic arthritis reflect inflammation assessed by ultrasound and magnetic resonance imaging?
作者: Sara Kamp Felbo.;Charlotte Wiell.;Mikkel Østergaard.;René Panduro Poggenborg.;Pernille Bøyesen.;Hilde Berner Hammer.;Annelies Boonen.;Susanne Juhl Pedersen.;Inge Juul Sørensen.;Ole Rintek Madsen.;Ole Slot.;Jakob Møllenbach Møller.;Marcin Szkudlarek.;Lene Terslev.
来源: Rheumatology (Oxford). 2022年61卷2期723-733页
To investigate the association between clinical joint tenderness and intra- and periarticular inflammation as assessed by ultrasound and MRI in patients with active PsA and to explore if the associations differ according to patient-reported outcomes (PROs) and structural damage.
4455. Antiviral proinflammatory phenotype of monocytes in anti-MDA5 antibody-associated interstitial lung disease.
To evaluate upstream and downstream regulators leading to macrophage activation and subsequent cytokine storm in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-associated interstitial lung disease (ILD).
4456. The sFlt-1 to PlGF ratio in pregnant women with rheumatoid arthritis: impact of disease activity and sulfasalazine use.
作者: Rugina I Neuman.;Hieronymus T W Smeele.;A H Jan Danser.;Radboud J E M Dolhain.;Willy Visser.
来源: Rheumatology (Oxford). 2022年61卷2期628-635页
An elevated sFlt-1/PlGF ratio has been validated as a significant predictor of preeclampsia, but has not been established in women with RA. We explored whether the sFlt-1/PlGFratio could be altered due to disease activity in RA, and could be applied in this population to predict preeclampsia. Since SSZ has been suggested to improve the angiogenic imbalance in preeclampsia, we also aimed to examine whether SSZ could affect sFlt-1 or PlGF levels.
4457. A novel fluorescence optical imaging scoring system for hand synovitis in rheumatoid arthritis-validity and agreement with ultrasound.
作者: Mads Ammitzbøll-Danielsen.;Daniel Glinatsi.;Lene Terslev.;Mikkel Østergaard.
来源: Rheumatology (Oxford). 2022年61卷2期636-647页
To develop and validate a new semiquantitative fluorescence optical imaging (FOI) scoring system-the FOI Enhancement-Generated RA Score (FOIE-GRAS) for synovitis assessment in the hand.
4458. Altered CD4+ T cell and cytokine levels in peripheral blood and skin samples from systemic sclerosis patients and IL-35 in CD4+ T cell growth.
作者: Chenxi Yang.;Ling Lei.;Jie Pan.;Cheng Zhao.;Jing Wen.;Fang Qin.;Fei Dong.;Wanling Wei.
来源: Rheumatology (Oxford). 2022年61卷2期794-805页
This study explored the role of IL-35 in CD4+ T lymphocyte and human skin fibroblast (HSF) activity and cytokine levels in systemic sclerosis.
4459. Patients with early-onset primary Sjögren's syndrome have distinctive clinical manifestations and circulating lymphocyte profiles.
作者: Lin Wei.;Xin Zhifei.;Ning Xiaoran.;Liu Meilu.;Li Yang.;Liu Yixuan.;Ren Xiuying.;Su Yashuang.;Cao Jingjing.;Guo Shaoying.;Yang Liu.;Sun Lijun.;Zhang Fengxiao.;Zhang Wen.
来源: Rheumatology (Oxford). 2022年61卷2期597-605页
To further investigate the clinical characteristics and circulating lymphocyte profiles of patients with early-onset primary Sjögren's syndrome (pSS).
4460. Patient and rheumatologist perspectives on tapering DMARDs in rheumatoid arthritis: a qualitative study.
作者: Glen S Hazlewood.;Adalberto Loyola-Sanchez.;Vivian Bykerk.;Pauline M Hull.;Deborah Marshall.;Tram Pham.;Claire E H Barber.;Cheryl Barnabe.;Alexandra Sirois.;Janet Pope.;Orit Schieir.;Dawn Richards.;Laurie Proulx.;Susan J Bartlett.
来源: Rheumatology (Oxford). 2022年61卷2期606-616页
To understand the perspectives of patients and rheumatologists for tapering DMARDs in RA.
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