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4421. Diagnostic accuracy of high-resolution peripheral quantitative computed tomography and X-ray for classifying erosive rheumatoid arthritis.
作者: Rasmus Klose-Jensen.;Josephine Therkildsen.;Anne-Birgitte Garm Blavnsfeldt.;Bente L Langdahl.;Anna Zejden.;Jesper Thygesen.;Kresten Krarup Keller.;Ellen-Margrethe Hauge.
来源: Rheumatology (Oxford). 2022年61卷3期963-973页
To investigate whether high-resolution peripheral quantitative CT (HR-pQCT) of two metacarpophalangeal (MCP) joints can more accurately classify patients as having erosive RA compared with conventional radiography (CR) of 44 joints in the hands, wrists and feet.
4422. What's new on the sacroiliac joint ? Comment on: "Joint anatomy in axial spondyloarthritis: strong associations between sacroiliac joint form variation and symptomatic disease".4424. Blood PD-1+TFh and CTLA-4+CD4+ T cells predict remission after CTLA-4Ig treatment in early rheumatoid arthritis.
作者: Jonathan Aldridge.;Kerstin Andersson.;Inger Gjertsson.;Anna-Karin Hultgård Ekwall.;Magnus Hallström.;Ronald van Vollenhoven.;Anna-Carin Lundell.;Anna Rudin.
来源: Rheumatology (Oxford). 2022年61卷3期1233-1242页
Treatment with CTLA-4Ig blocks T-cell activation and is clinically effective in RA. However, it is unknown if specific CD4+ T-cell subsets in blood at baseline predict remission after CTLA-4Ig, or other biological treatments with different modes of action, and how treatment affects CD4+ T cells in patients with untreated early RA (eRA).
4426. Temporal artery biopsy revealing marginal zone lymphoma in a patient with eosinophilic granulomatosis with polyangiitis.
作者: Shubhasree Banerjee.;Franz Fogt.;Dale M Frank.;James Gerson.;Michael S Rosen.;Peter A Merkel.
来源: Rheumatology (Oxford). 2022年61卷3期1295-1296页 4427. Identification of a shared genetic risk locus for Kawasaki disease and immunoglobulin A vasculitis by a cross-phenotype meta-analysis.
作者: Elio G Carmona.;Jose A García-Giménez.;Raquel López-Mejías.;Chiea Chuen Khor.;Jong-Keuk Lee.;Ekim Taskiran.;Seza Ozen.;Alojzija Hocevar.;Lili Liu.;Mario Gorenjak.;Uroš Potočnik.;Krzysztof Kiryluk.;Norberto Ortego-Centeno.;María C Cid.;José Hernández-Rodríguez.;Santos Castañeda.;Miguel A González-Gay.;David Burgner.;Javier Martín.;Ana Márquez.; .
来源: Rheumatology (Oxford). 2022年61卷3期1204-1210页
Combining of genomic data of different pathologies as a single phenotype has emerged as a useful strategy to identify genetic risk loci shared among immune-mediated diseases. Our study aimed to increase our knowledge of the genetic contribution to Kawasaki disease (KD) and IgA vasculitis (IgAV) by performing the first comprehensive large-scale analysis on the genetic overlap between them.
4428. Pulmonary fibrosis in relation to genetic loci in an inception cohort of patients with early rheumatoid arthritis from northern Sweden.
作者: Elias Jönsson.;Lotta Ljung.;Eva Norrman.;Eva Freyhult.;Lisbeth Ärlestig.;Johanna Dahlqvist.;Solbritt Rantapää-Dahlqvist.
来源: Rheumatology (Oxford). 2022年61卷3期943-952页
Pulmonary manifestations in RA are common comorbidities. Interstitial lung disease (ILD), both idiopathic and in RA, has been associated with several genetic variants. We assessed pulmonary fibrosis (PF) in an inception cohort of RA patients in relation to genetic variants and disease-related factors.
4429. Risk of diverticulitis and gastrointestinal perforation in rheumatoid arthritis treated with tocilizumab compared to rituximab or abatacept.
作者: Claire Rempenault.;Cédric Lukas.;Bernard Combe.;Astrid Herrero.;Isabelle Pane.;Thierry Schaeverbeke.;Daniel Wendling.;Thao Pham.;Jacques-Eric Gottenberg.;Xavier Mariette.;Jacques Morel.; .
来源: Rheumatology (Oxford). 2022年61卷3期953-962页
To compare the risk of diverticulitis and gastrointestinal perforation (GIP) in RA treated with tocilizumab (TCZ) compared with rituximab (RTX) and abatacept (ABA).
4432. Representativeness of systemic sclerosis patients in interventional randomized trials: an analysis of the EUSTAR database.
作者: Michele Iudici.;Matthias Jarlborg.;Kim Lauper.;Ulf Müller-Ladner.;Vanessa Smith.;Yannick Allanore.;Alexandra Balbir-Gurman.;Andrea Doria.;Paolo Airò.;Ulrich A Walker.;Valeria Riccieri.;Madelon C Vonk.;Armando Gabrielli.;Anna-Maria Hoffmann-Vold.;Gabriella Szücs.;Thierry Martin.;Oliver Distler.;Delphine S Courvoisier.; .
来源: Rheumatology (Oxford). 2022年61卷2期743-755页
To estimate the extent of and the reasons for ineligibility in randomized controlled trials (RCTs) of SSc patients included in the EUSTAR database, and to determine the association between patient's features and generalizability of study results.
4433. The role of TNFRSF11B in development of osteoarthritic cartilage.
作者: Alejandro Rodríguez Ruiz.;Margo Tuerlings.;Ankita Das.;Rodrigo Coutinho de Almeida.;H Eka D Suchiman.;Rob G H H Nelissen.;Yolande F M Ramos.;Ingrid Meulenbelt.
来源: Rheumatology (Oxford). 2022年61卷2期856-864页
OA is a complex genetic disease with different risk factors contributing to its development. One of the genes, TNFRSF11B, previously identified with gain-of-function mutation in a family with early-onset OA with chondrocalcinosis, is among the highest upregulated genes in lesioned OA cartilage (RAAK-study). Here, we determined the role of TNFRSF11B overexpression in development of OA.
4434. Development and validation of a prediction model for glucocorticoid-associated osteonecrosis of the femoral head by targeted sequencing.
作者: Chang Jiang.;Xinyuan Wang.;Kai Huang.;Limeng Chen.;Zongfei Ji.;Bingxuan Hua.;Guobin Qi.;Hengfeng Yuan.;Yuanwu Cao.;Lindi Jiang.;David Haixiang Peng.;Zuoqin Yan.
来源: Rheumatology (Oxford). 2022年61卷2期846-855页
To develop and validate a prediction model based on targeted sequencing for glucocorticoid (GC)-associated osteonecrosis of the femoral head (GA-ONFH) in GC-treated adults.
4435. Diagnostic delay is common for patients with axial spondyloarthritis: results from the National Early Inflammatory Arthritis Audit.
作者: Mark D Russell.;Fiona Coath.;Mark Yates.;Katie Bechman.;Sam Norton.;James B Galloway.;Joanna Ledingham.;Raj Sengupta.;Karl Gaffney.
来源: Rheumatology (Oxford). 2022年61卷2期734-742页
Updated guidelines for patients with axial SpA (axSpA) have sought to reduce diagnostic delay by raising awareness among clinicians. We used the National Early Inflammatory Arthritis Audit (NEIAA) to describe baseline characteristics and time to diagnosis for newly referred patients with axSpA in England and Wales.
4436. Significance of Sjögren's syndrome and anti-cN1A antibody in myositis patients.
作者: Dan Levy.;Benoit Nespola.;Margherita Giannini.;Renaud Felten.;François Severac.;Coralie Varoquier.;Marina Rinagel.;Anne-Sophie Korganow.;Thierry Martin.;Vincent Poindron.;Francois Maurier.;Haitham Chereih.;Bastien Bouldoires.;Baptiste Hervier.;Cedric Lenormand.;Emmanuel Chatelus.;Bernard Geny.;Jean Sibilia.;Laurent Arnaud.;Jacques-Eric Gottenberg.;Alain Meyer.
来源: Rheumatology (Oxford). 2022年61卷2期756-763页
We recently recorded a high prevalence of inclusion body myositis (IBM) in patients with Sjögren's syndrome (SS). Whether myositis patients with SS differ from myositis patients without SS in terms of the characteristics of the myositis is currently unknown. Anti-cytosolic 5'-nucleotidase 1 A (cN1A) has recently been proposed as a biomarker for IBM but is also frequent in SS. Whether anti-cN1A is independently associated with IBM is still an open question. We aimed to assess the significance of SS and anti-cN1A in myositis patients.
4440. Danger-associated molecular pattern molecules and the receptor for advanced glycation end products enhance ANCA-induced responses.
作者: Theresa H Page.;Derick Chiappo.;Francesca Brunini.;Josep Garnica.;Jack Blackburn.;Fayaz Dudhiya.;Maria Prendecki.;Stephen P McAdoo.;Charles D Pusey.
来源: Rheumatology (Oxford). 2022年61卷2期834-845页
The pro-inflammatory activities of the calgranulins and HMGB1 can be counteracted by sRAGE, the soluble form of their shared receptor. To understand the role of these molecules in AAV and their potential as therapeutic targets we have studied (i) the relationship between these DAMPS and disease activity; (ii) the expression of RAGE and sRAGE in biopsy tissue and peripheral blood; and (iii) the effect of these molecules on ANCA-mediated cytokine production.
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