"N Engl J Med"[journal] 检索结果

4401. Audio Interview: Dissecting the Host Response to SARS-CoV-2.

作者: Eric J Rubin.;Lindsey R Baden.;Penny L Moore.;Stephen Morrissey.
来源: N Engl J Med. 2022年386卷22期e69页

4402. Racial and Ethnic Diversity of U.S. Residency Programs, 2011-2019.

作者: Lauren Hucko.;Hasenin Al-Khersan.;Johanny Lopez Dominguez.;Kara M Cavuoto.;Nathan L Scott.;Basil K Williams.;Tamara Fountain.;Jayanth Sridhar.
来源: N Engl J Med. 2022年386卷22期2152-2153页

4403. Routine Removal of Inferior Vena Cava Filters.

作者: Clement Lee.;S William Stavropoulos.;William T Kuo.
来源: N Engl J Med. 2022年386卷22期2149-2151页

4404. Targeting Cytotoxic T Cells to Tumor.

作者: Elizabeth G Phimister.;Eric J Rubin.
来源: N Engl J Med. 2022年386卷22期2145-2148页

4405. T-Cell Immunotherapy against Mutant KRAS for Pancreatic Cancer.

作者: Cornelis J M Melief.
来源: N Engl J Med. 2022年386卷22期2143-2144页

4406. Another Rescue Therapy Option for Patients with Moderate-to-Severe Asthma.

作者: Michael Schatz.
来源: N Engl J Med. 2022年386卷22期2139-2140页

4407. The Science behind the Study.

作者: Elizabeth G Phimister.;Mary Beth Hamel.;Stephen Morrissey.;Eric Rubin.
来源: N Engl J Med. 2022年386卷22期2138页

4408. The After-Dinner Dip.

作者: Gertrud L G Haverkamp.;Richard G Ijzerman.;Jos Kooter.;Yvonne H M Krul-Poel.
来源: N Engl J Med. 2022年386卷22期2130-2136页

4409. Eruptive Xanthomas.

作者: Mingyuan Xu.;Yeqiang Liu.
来源: N Engl J Med. 2022年386卷22期e58页

4410. Uses of GFR and Albuminuria Level in Acute and Chronic Kidney Disease.

作者: Andrew S Levey.;Morgan E Grams.;Lesley A Inker.
来源: N Engl J Med. 2022年386卷22期2120-2128页

4411. Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer.

作者: Rom Leidner.;Nelson Sanjuan Silva.;Huayu Huang.;David Sprott.;Chunhong Zheng.;Yi-Ping Shih.;Amy Leung.;Roxanne Payne.;Kim Sutcliffe.;Julie Cramer.;Steven A Rosenberg.;Bernard A Fox.;Walter J Urba.;Eric Tran.
来源: N Engl J Med. 2022年386卷22期2112-2119页

A patient with progressive metastatic pancreatic cancer was treated with a single infusion of 16.2×109 autologous T cells that had been genetically engineered to clonally express two allogeneic HLA-C*08:02-restricted T-cell receptors (TCRs) targeting mutant KRAS G12D expressed by the tumors. The patient had regression of visceral metastases (overall partial response of 72% according to the Response Evaluation Criteria in Solid Tumors, version 1.1); the response was ongoing at 6 months. The engineered T cells constituted more than 2% of all the circulating peripheral-blood T cells 6 months after the cell transfer. In this patient, TCR gene therapy targeting the KRAS G12D driver mutation mediated the objective regression of metastatic pancreatic cancer. (Funded by the Providence Portland Medical Foundation.).

4412. Turbocharging the T Cell to Fight Cancer.

作者: Andrea Schietinger.
来源: N Engl J Med. 2022年386卷24期2334-2336页

4413. Perverse Incentives - HIV Prevention and the 340B Drug Pricing Program.

作者: Julia L Marcus.;Amy Killelea.;Douglas S Krakower.
来源: N Engl J Med. 2022年386卷22期2064-2066页

4414. Daughters' Keeper - The Care and Treatment of Black Girls in America.

作者: Kevin M Simon.
来源: N Engl J Med. 2022年386卷22期2067-2069页

4415. Eruptive Xanthomas with Branching Projections.

作者: Jiaqiang Zhou.;Hao Cheng.
来源: N Engl J Med. 2022年386卷22期2129页

4416. Effectiveness of Homologous and Heterologous Covid-19 Boosters against Omicron.

作者: Emma K Accorsi.;Amadea Britton.;Nong Shang.;Katherine E Fleming-Dutra.;Ruth Link-Gelles.;Zachary R Smith.;Gordana Derado.;Joseph Miller.;Stephanie J Schrag.;Jennifer R Verani.
来源: N Engl J Med. 2022年386卷25期2433-2435页

4417. Medicalizing the Constitution?

作者: M Gregg Bloche.
来源: N Engl J Med. 2022年386卷25期2357-2359页

4418. Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2.

作者: Yair Goldberg.;Micha Mandel.;Yinon M Bar-On.;Omri Bodenheimer.;Laurence S Freedman.;Nachman Ash.;Sharon Alroy-Preis.;Amit Huppert.;Ron Milo.
来源: N Engl J Med. 2022年386卷23期2201-2212页

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provides natural immunity against reinfection. Recent studies have shown waning of the immunity provided by the BNT162b2 vaccine. The time course of natural and hybrid immunity is unknown.

4419. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. Reply.

作者: Stefan D Anker.;Javed Butler.;Milton Packer.
来源: N Engl J Med. 2022年386卷21期e57页

4420. Empagliflozin in Heart Failure with a Preserved Ejection Fraction.

作者: Hiddo J L Heerspink.;Lesley Inker.;Tom Greene.
来源: N Engl J Med. 2022年386卷21期e57页

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