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4381. Serological abnormalities that predict progression to systemic autoimmune rheumatic diseases in antinuclear antibody-positive individuals.
作者: Carolina Muñoz-Grajales.;Stephenie D Prokopec.;Sindhu R Johnson.;Zahi Touma.;Zareen Ahmad.;Dennisse Bonilla.;Linda Hiraki.;Arthur Bookman.;Paul C Boutros.;Andrzej Chruscinski.;Joan Wither.
来源: Rheumatology (Oxford). 2022年61卷3期1092-1105页
We investigated the autoantibody (autoAb) profiles in ANA+ individuals lacking systemic autoimmune rheumatic disease (SARD) and early SARD patients to determine the key differences between these groups and identify factors that are associated with an increased risk of symptomatic progression within the next 2 years in ANA+ individuals.
4382. Impact of barrier tissue inflammation and physical activity on joint homeostasis in mice.
作者: Margot Van Mechelen.;Tobie Martens.;Pieter Vanden Berghe.;Rik Lories.;Giulia R Gulino.
来源: Rheumatology (Oxford). 2022年61卷4期1690-1698页
To investigate whether physical activity interferes with joint homeostasis in the presence of distant inflammation originating at barrier tissues such as skin or gut.
4383. Ultrasound of shoulder and knee improves the accuracy of the 2012 EULAR/ACR provisional classification criteria for polymyalgia rheumatica.
作者: Kei Kobayashi.;Daiki Nakagomi.;Yoshiaki Kobayashi.;Chisaki Ajima.;Shunichiro Hanai.;Kensuke Koyama.;Kei Ikeda.
来源: Rheumatology (Oxford). 2022年61卷3期1185-1194页
Recent studies suggest that the knee is frequently involved in PMR. In this study, we aimed to determine whether the US assessment of the shoulder and knee discriminates between PMR and other differential diagnoses and improves the accuracy of the 2012 EULAR/ACR provisional classification criteria for PMR.
4384. MRI-detected synovitis of the small joints predicts rheumatoid arthritis development in large joint undifferentiated inflammatory arthritis.
作者: Navkiran Sidhu.;Fenne Wouters.;Ellis Niemantsverdriet.;Annette H M van der Helm-van Mil.
来源: Rheumatology (Oxford). 2022年61卷SI期SI23-SI29页
New onset undifferentiated large joint inflammatory arthritis can be diagnostically challenging. It is unknown how often these patients progress to RA, and how they can be identified at first presentation. We assessed clinical and serological features associated with RA development in patients with an undifferentiated mono- or oligo-articular large joint arthritis, and with keen interest in whether an MRI of the small joints of the hand and foot would aid diagnosis.
4385. All-cause and cause-specific mortality in patients with giant cell arteritis: a nationwide, population-based cohort study.
作者: Philip Therkildsen.;Berit Dalsgaard Nielsen.;Annette de Thurah.;Ib Tønder Hansen.;Mette Nørgaard.;Ellen-Margrethe Hauge.
来源: Rheumatology (Oxford). 2022年61卷3期1195-1203页
To investigate whether GCA is associated with increased all-cause and cause-specific mortality.
4386. Brain white matter extracellular free-water increases are related to reduced neurocognitive function in systemic lupus erythematosus.
作者: Xing Qian.;Fang Ji.;Kwun Kei Ng.;Amelia Jialing Koh.;Beatrice Rui Yi Loo.;Mary Charlotte Townsend.;Ofer Pasternak.;Sen Hee Tay.;Juan Helen Zhou.;Anselm Mak.
来源: Rheumatology (Oxford). 2022年61卷3期1166-1174页
Brain white matter (WM) microstructural changes evaluated by diffusion MRI are well documented in patients with SLE. Yet, the conventional diffusion tensor imaging technique fails to differentiate WM changes that originate from tissue alterations from those due to increased extracellular free water (FW) related to neuroinflammation, microvascular disruption, atrophy, or other extracellular processes. Here, we sought to delineate changes in WM tissue microstructure and extracellular FW volume and examine their relationships with neurocognitive function in SLE patients.
4387. A novel model to assess disease activity in Takayasu arteritis based on 18F-FDG-PET/CT: a Chinese cohort study.
作者: Ling-Ying Ma.;Bing Wu.;Xue-Juan Jin.;Ying Sun.;Xiu-Fang Kong.;Zong-Fei Ji.;Rong-Yi Chen.;Xiao-Meng Cui.;Hong-Cheng Shi.;Lin-Di Jiang.
来源: Rheumatology (Oxford). 2022年61卷SI期SI14-SI22页
To investigate the utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in assessing disease activity in Takayasu arteritis (TA).
4388. Revisiting characteristics, treatment and outcome of cardiomyopathy in eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss).
作者: Silvia Sartorelli.;Guillaume Chassagnon.;Pascal Cohen.;Bertrand Dunogué.;Xavier Puéchal.;Alexis Régent.;Luc Mouthon.;Loïc Guillevin.;Benjamin Terrier.; .
来源: Rheumatology (Oxford). 2022年61卷3期1175-1184页
Eosinophilic granulomatosis with polyangiitis (EGPA) is a necrotizing eosinophil-rich vasculitis. Specific cardiomyopathy (CM) was described in early studies as the most important predictor of mortality. We aimed to revisit EGPA-related CM and investigate its outcome in recent decades.
4389. Inorganic pyrophosphate is reduced in patients with systemic sclerosis.
作者: Vivien M Hsu.;Eszter Kozák.;Qiaoli Li.;Márta Bocskai.;Naomi Schlesinger.;Ann Rosenthal.;Scott T McClure.;László Kovács.;László Bálint.;Szilvia Szamosi.;Gabriella Szücs.;Mary Carns.;Kathleen Aren.;Isaac Goldberg.;András Váradi.;John Varga.
来源: Rheumatology (Oxford). 2022年61卷3期1158-1165页
The pathogenesis of calcinosis cutis, a disabling complication of SSc, is poorly understood and effective treatments are lacking. Inorganic pyrophosphate (PPi) is a key regulator of ectopic mineralization, and its deficiency has been implicated in ectopic mineralization disorders. We therefore sought to test the hypothesis that SSc may be associated with reduced circulating PPi, which might play a pathogenic role in calcinosis cutis.
4390. Anti-nuclear matrix protein 2 antibody-positive inflammatory myopathies represent extensive myositis without dermatomyositis-specific rash.
作者: Yuki Ichimura.;Risa Konishi.;Miwako Shobo.;Sae Inoue.;Mari Okune.;Akemi Maeda.;Ryota Tanaka.;Noriko Kubota.;Isao Matsumoto.;Akiko Ishii.;Akira Tamaoka.;Asami Shimbo.;Masaaki Mori.;Tomohiro Morio.;Takayuki Kishi.;Takako Miyamae.;Jantima Tanboon.;Michio Inoue.;Ichizo Nishino.;Manabu Fujimoto.;Toshifumi Nomura.;Naoko Okiyama.
来源: Rheumatology (Oxford). 2022年61卷3期1222-1227页
Myositis-specific autoantibodies (MSAs) define distinct clinical subsets of idiopathic inflammatory myopathies (IIMs). The anti-nuclear matrix protein 2 (NXP2) antibody, a MSA detected in juvenile/adult IIMs, has been reported to be associated with a high risk of subcutaneous calcinosis, subcutaneous oedema and internal malignancies. The study aimed to clarify the clinical features of anti-NXP2 antibody-positive IIMs in detail.
4391. Real-life efficacy of guselkumab in patients with early psoriatic arthritis.
作者: Ilenia Pantano.;Daniele Mauro.;Francesca Romano.;Alessio Gambardella.;Mario Valenti.;Davide Simone.;Daniela Iacono.;Antonio Costanzo.;Giuseppe Argenziano.;Francesco Ciccia.
来源: Rheumatology (Oxford). 2022年61卷3期1217-1221页
To assess the efficacy of the novel anti-IL-23 monoclonal antibody guselkumab in a real-life observational cohort of patients with early PsA.
4392. Digital pitting scars are associated with a severe disease course and death in systemic sclerosis: a study from the EUSTAR cohort.
作者: Michael Hughes.;Calvin Heal.;Jörg Henes.;Alexandra Balbir-Gurman.;Jörg H W Distler.;Paolo Airò.;Ulf Müller-Ladner.;Nicolas Hunzelmann.;Eduardo Kerzberg.;Lidia Rudnicka.;Marie-Elise Truchetet.;Simon Stebbings.;Yoshiya Tanaka.;Anna Maria Hoffman-Vold.;Armando Gabrielli.;Oliver Distler.;Marco Matucci-Cerinic.; .
来源: Rheumatology (Oxford). 2022年61卷3期1141-1147页
Digital pitting scars (DPS) are frequent, but little studied in SSc to date.
4393. Autoantibody profiles delineate distinct subsets of scleromyositis.
作者: Valérie Leclair.;Julie D'Aoust.;Geneviève Gyger.;Océane Landon-Cardinal.;Alain Meyer.;Erin O'Ferrall.;Jason Karamchandani.;Rami Massie.;Benjamin Ellezam.;Minoru Satoh.;Yves Troyanov.;Marvin J Fritzler.;Marie Hudson.; .
来源: Rheumatology (Oxford). 2022年61卷3期1148-1157页
Scleromyositis remains incompletely characterized owing in part to its heterogeneity. The purpose of this study was to explore the role of autoantibody profiles to define subsets of scleromyositis.
4394. Bidirectional association between systemic lupus erythematosus and macrophage activation syndrome: a nationwide population-based study.
作者: Lu-Wei Huang.;James Cheng-Chung Wei.;Der-Yuan Chen.;Yen-Ju Chen.;Kuo-Tung Tang.;Tai-Ming Ko.;Hsin-Hua Chen.
来源: Rheumatology (Oxford). 2022年61卷3期1123-1132页
To determine the bidirectional relationship between macrophage activation syndrome (MAS) and SLE.
4395. Behçet's disease and activities of daily living.
作者: Aoi Nagano.;Masaki Takeuchi.;Nobuyuki Horita.;Takeshi Teshigawara.;Tatsukata Kawagoe.;Yuki Mizuki.;Akira Meguro.;Hiroto Nakano.;Yohei Kirino.;Kaoru Takase-Minegishi.;Ryusuke Yoshimi.;Michiko Kurosawa.;Takeshi Fukumoto.;Mitsuhiro Takeno.;Takeshi Kaneko.;Nobuhisa Mizuki.
来源: Rheumatology (Oxford). 2022年61卷3期1133-1140页
No large-scale registration study has comprehensively evaluated the activities of daily living (ADL) in patients with Behçet's disease.
4396. Significance of eosinophilia in granulomatosis with polyangiitis: data from the French Vasculitis Study Group Registry.
作者: Michele Iudici.;Xavier Puéchal.;Christian Pagnoux.;Delphine S Courvoisier.;Mohamed Hamidou.;Claire Blanchard-Delaunay.;François Maurier.;Marc Ruivard.;Thomas Quéméneur.;Olivier Aumaître.;Loïc Guillevin.;Benjamin Terrier.; .
来源: Rheumatology (Oxford). 2022年61卷3期1211-1216页
To describe disease presentation and long-term outcome of granulomatosis with polyangiitis (GPA) patients according to blood eosinophils count (Eos) at vasculitis diagnosis.
4397. Performance of finger systolic blood pressure measurement to detect digital occlusive arterial disease in systemic sclerosis.
作者: Loukman Omarjee.;Antoine Metairie.;Therese Tueguem Moyo.;Estelle Le Pabic.;Patrick Jego.;Alain Lescoat.;Guillaume Mahe.
来源: Rheumatology (Oxford). 2022年61卷3期1115-1122页
Digital ulcers related to digital occlusive arterial disease (DOAD) are frequent in patients with SSc. Finger systolic blood pressure (FSBP) and digital-brachial pressure index (DBI) using laser Doppler flowmetry constitute a non-invasive means of detecting DOAD in SSc, although thresholds have yet to be established for defining DOAD. The purpose of this study was to ascertain FSBP and DBI thresholds to detect DOAD in SSc patients. The intra/interday reproducibility of curve reading by four vascular physicians in relation to finger pressure measurement was also investigated.
4398. Intravenous prostanoids in systemic sclerosis-associated pulmonary arterial hypertension: a single-centre experience.
作者: Maria Vlachou.;Hossam Fayed.;Adele Dawson.;Sally Reddecliffe.;Alexander Stevenson.;Ross J Thomson.;Benjamin Emmanuel Schreiber.;J Gerry Coghlan.
来源: Rheumatology (Oxford). 2022年61卷3期1106-1114页
The current study evaluates survival rates among SSc-associated pulmonary arterial hypertension (SSc-PAH) patients on i.v. prostanoids, and short-term impact of i.v. prostanoids on clinical and haemodynamic parameters.
4399. Efficacy and safety of switching from reference adalimumab to CT-P17 (100 mg/ml): 52-week randomized, double-blind study in rheumatoid arthritis.
作者: Daniel E Furst.;Janusz Jaworski.;Rafal Wojciechowski.;Piotr Wiland.;Anna Dudek.;Marek Krogulec.;Slawomir Jeka.;Agnieszka Zielinska.;Jakub Trefler.;Katarzyna Bartnicka-Maslowska.;Magdalena Krajewska-Wlodarczyk.;Piotr A Klimiuk.;Sang Joon Lee.;Sung Hyun Kim.;Yun Ju Bae.;Go Eun Yang.;Jae Kyoung Yoo.;Jonathan Kay.;Edward Keystone.
来源: Rheumatology (Oxford). 2022年61卷4期1385-1395页
To compare the safety and efficacy of switching from reference adalimumab to adalimumab biosimilar CT-P17 with continuing reference adalimumab/CT-P17 in active RA.
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