4357. Cystatin C-Based Equation to Estimate GFR without the Inclusion of Race and Sex.
作者: Hans Pottel.;Jonas Björk.;Andrew D Rule.;Natalie Ebert.;Björn O Eriksen.;Laurence Dubourg.;Emmanuelle Vidal-Petiot.;Anders Grubb.;Magnus Hansson.;Edmund J Lamb.;Karin Littmann.;Christophe Mariat.;Toralf Melsom.;Elke Schaeffner.;Per-Ola Sundin.;Anna Åkesson.;Anders Larsson.;Etienne Cavalier.;Justine B Bukabau.;Ernest K Sumaili.;Eric Yayo.;Dagui Monnet.;Martin Flamant.;Ulf Nyman.;Pierre Delanaye.
来源: N Engl J Med. 2023年388卷4期333-343页
The accuracy of estimation of kidney function with the use of routine metabolic tests, such as measurement of the serum creatinine level, has been controversial. The European Kidney Function Consortium (EKFC) developed a creatinine-based equation (EKFC eGFRcr) to estimate the glomerular filtration rate (GFR) with a rescaled serum creatinine level (i.e., the serum creatinine level is divided by the median serum creatinine level among healthy persons to control for variation related to differences in age, sex, or race). Whether a cystatin C-based EKFC equation would increase the accuracy of estimated GFR is unknown.
4358. Efanesoctocog Alfa Prophylaxis for Patients with Severe Hemophilia A.
作者: Annette von Drygalski.;Pratima Chowdary.;Roshni Kulkarni.;Sophie Susen.;Barbara A Konkle.;Johannes Oldenburg.;Davide Matino.;Robert Klamroth.;Angela C Weyand.;Victor Jimenez-Yuste.;Keiji Nogami.;Stacey Poloskey.;Bent Winding.;Annemieke Willemze.;Karin Knobe.; .
来源: N Engl J Med. 2023年388卷4期310-318页
Efanesoctocog alfa provides high sustained factor VIII activity by overcoming the von Willebrand factor-imposed half-life ceiling. The efficacy, safety, and pharmacokinetics of efanesoctocog alfa for prophylaxis and treatment of bleeding episodes in previously treated patients with severe hemophilia A are unclear.
4359. Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest.
作者: Martje M Suverein.;Thijs S R Delnoij.;Roberto Lorusso.;George J Brandon Bravo Bruinsma.;Luuk Otterspoor.;Carlos V Elzo Kraemer.;Alexander P J Vlaar.;Joris J van der Heijden.;Erik Scholten.;Corstiaan den Uil.;Tim Jansen.;Bas van den Bogaard.;Marijn Kuijpers.;Ka Yan Lam.;José M Montero Cabezas.;Antoine H G Driessen.;Saskia Z H Rittersma.;Bram G Heijnen.;Dinis Dos Reis Miranda.;Gabe Bleeker.;Jesse de Metz.;Renicus S Hermanides.;Jorge Lopez Matta.;Susanne Eberl.;Dirk W Donker.;Robert J van Thiel.;Sakir Akin.;Oene van Meer.;José Henriques.;Karen C Bokhoven.;Loes Mandigers.;Jeroen J H Bunge.;Martine E Bol.;Bjorn Winkens.;Brigitte Essers.;Patrick W Weerwind.;Jos G Maessen.;Marcel C G van de Poll.
来源: N Engl J Med. 2023年388卷4期299-309页
Extracorporeal cardiopulmonary resuscitation (CPR) restores perfusion and oxygenation in a patient who does not have spontaneous circulation. The evidence with regard to the effect of extracorporeal CPR on survival with a favorable neurologic outcome in refractory out-of-hospital cardiac arrest is inconclusive.
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