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4335. Sequential Stem Cell-Kidney Transplantation in Schimke Immuno-osseous Dysplasia.
作者: Alice Bertaina.;Paul C Grimm.;Kenneth Weinberg.;Robertson Parkman.;Karen M Kristovich.;Giulia Barbarito.;Elizabeth Lippner.;Girija Dhamdhere.;Vasavi Ramachandran.;Jordan M Spatz.;Sahar Fathallah-Shaykh.;T Prescott Atkinson.;Amira Al-Uzri.;Geraldine Aubert.;Kim van der Elst.;Sean G Green.;Rajni Agarwal.;Priscila F Slepicka.;Ami J Shah.;Maria G Roncarolo.;Amy Gallo.;Waldo Concepcion.;David B Lewis.
来源: N Engl J Med. 2022年386卷24期2295-2302页
Lifelong immunosuppression is required for allograft survival after kidney transplantation but may not ultimately prevent allograft loss resulting from chronic rejection. We developed an approach that attempts to abrogate immune rejection and the need for post-transplantation immunosuppression in three patients with Schimke immuno-osseous dysplasia who had both T-cell immunodeficiency and renal failure. Each patient received sequential transplants of αβ T-cell-depleted and CD19 B-cell-depleted haploidentical hematopoietic stem cells and a kidney from the same donor. Full donor hematopoietic chimerism and functional ex vivo T-cell tolerance was achieved, and the patients continued to have normal renal function without immunosuppression at 22 to 34 months after kidney transplantation. (Funded by the Kruzn for a Kure Foundation.).
4336. Chapare Hemorrhagic Fever and Virus Detection in Rodents in Bolivia in 2019.
作者: Roxana Loayza Mafayle.;Maria E Morales-Betoulle.;Carla Romero.;Caitlin M Cossaboom.;Shannon Whitmer.;Carlos E Alvarez Aguilera.;Cinthia Avila Ardaya.;Mirian Cruz Zambrana.;Andrés Dávalos Anajia.;Nelly Mendoza Loayza.;Ana-Maria Montaño.;Fernando L Morales Alvis.;Jimmy Revollo Guzmán.;Sebastián Sasías Martínez.;Gricel Alarcón De La Vega.;Armando Medina Ramírez.;Jhemis T Molina Gutiérrez.;Alex J Cornejo Pinto.;Renata Salas Bacci.;Julia Brignone.;Jorge Garcia.;Arletta Añez.;Jairo Mendez-Rico.;Kleber Luz.;Ariel Segales.;Karen M Torrez Cruz.;Adolfo Valdivia-Cayoja.;Brian R Amman.;Mary J Choi.;Bobbie-Rae Erickson.;Cynthia Goldsmith.;James C Graziano.;Allison Joyce.;John D Klena.;Austin Leach.;Jason H Malenfant.;Stuart T Nichol.;Ketan Patel.;Tara Sealy.;Trevor Shoemaker.;Christina F Spiropoulou.;Alison Todres.;Jonathan S Towner.;Joel M Montgomery.
来源: N Engl J Med. 2022年386卷24期2283-2294页
In June 2019, the Bolivian Ministry of Health reported a cluster of cases of hemorrhagic fever that started in the municipality of Caranavi and expanded to La Paz. The cause of these cases was unknown.
4337. Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer.
作者: Joel M Palefsky.;Jeannette Y Lee.;Naomi Jay.;Stephen E Goldstone.;Teresa M Darragh.;Hillary A Dunlevy.;Isabella Rosa-Cunha.;Abigail Arons.;Julia C Pugliese.;Don Vena.;Joseph A Sparano.;Timothy J Wilkin.;Gary Bucher.;Elizabeth A Stier.;Maribel Tirado Gomez.;Lisa Flowers.;Luis F Barroso.;Ronald T Mitsuyasu.;Shelly Y Lensing.;Jeffrey Logan.;David M Aboulafia.;Jeffrey T Schouten.;Juan de la Ossa.;Rebecca Levine.;Jessica D Korman.;Michael Hagensee.;Thomas M Atkinson.;Mark H Einstein.;Bernadette M Cracchiolo.;Dorothy Wiley.;Grant B Ellsworth.;Cristina Brickman.;J Michael Berry-Lawhorn.; .
来源: N Engl J Med. 2022年386卷24期2273-2282页
The incidence of anal cancer is substantially higher among persons living with the human immunodeficiency virus (HIV) than in the general population. Similar to cervical cancer, anal cancer is preceded by high-grade squamous intraepithelial lesions (HSILs). Treatment for cervical HSIL reduces progression to cervical cancer; however, data from prospective studies of treatment for anal HSIL to prevent anal cancer are lacking.
4339. Neutralization of the SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants.
作者: Panke Qu.;Julia Faraone.;John P Evans.;Xue Zou.;Yi-Min Zheng.;Claire Carlin.;Joseph S Bednash.;Gerard Lozanski.;Rama K Mallampalli.;Linda J Saif.;Eugene M Oltz.;Peter J Mohler.;Richard J Gumina.;Shan-Lu Liu.
来源: N Engl J Med. 2022年386卷26期2526-2528页 |