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4302. Early Treatment with Pegylated Interferon Lambda for Covid-19.
作者: Gilmar Reis.;Eduardo A S Moreira Silva.;Daniela C Medeiros Silva.;Lehana Thabane.;Vitoria H S Campos.;Thiago S Ferreira.;Castilho V Q Santos.;Ana M R Nogueira.;Ana P F G Almeida.;Leonardo C M Savassi.;Adhemar D Figueiredo-Neto.;Ana C F Dias.;Adelino M Freire Júnior.;Carina Bitarães.;Aline C Milagres.;Eduardo D Callegari.;Maria I C Simplicio.;Luciene B Ribeiro.;Rosemary Oliveira.;Ofir Harari.;Lindsay A Wilson.;Jamie I Forrest.;Hinda Ruton.;Sheila Sprague.;Paula McKay.;Christina M Guo.;Eve H Limbrick-Oldfield.;Steve Kanters.;Gordon H Guyatt.;Craig R Rayner.;Christopher Kandel.;Mia J Biondi.;Robert Kozak.;Bettina Hansen.;M Atif Zahoor.;Paul Arora.;Colin Hislop.;Ingrid Choong.;Jordan J Feld.;Edward J Mills.;Jeffrey S Glenn.; .
来源: N Engl J Med. 2023年388卷6期518-528页
The efficacy of a single dose of pegylated interferon lambda in preventing clinical events among outpatients with acute symptomatic coronavirus disease 2019 (Covid-19) is unclear.
4303. Phase 2 Trial of Difelikefalin in Notalgia Paresthetica.
作者: Brian S Kim.;Robert Bissonnette.;Kristine Nograles.;Catherine Munera.;Nilam Shah.;Alia Jebara.;Joshua Cirulli.;Joana Goncalves.;Mark Lebwohl.; .
来源: N Engl J Med. 2023年388卷6期511-517页
Notalgia paresthetica is a neuropathic disorder characterized by pruritus in a circumscribed region of the upper back. Difelikefalin, a selective kappa opioid receptor agonist, has shown efficacy in other chronic pruritic conditions and is being investigated for the treatment of notalgia paresthetica.
4304. Lobar or Sublobar Resection for Peripheral Stage IA Non-Small-Cell Lung Cancer.
作者: Nasser Altorki.;Xiaofei Wang.;David Kozono.;Colleen Watt.;Rodney Landrenau.;Dennis Wigle.;Jeffrey Port.;David R Jones.;Massimo Conti.;Ahmad S Ashrafi.;Moishe Liberman.;Kazuhiro Yasufuku.;Stephen Yang.;John D Mitchell.;Harvey Pass.;Robert Keenan.;Thomas Bauer.;Daniel Miller.;Leslie J Kohman.;Thomas E Stinchcombe.;Everett Vokes.
来源: N Engl J Med. 2023年388卷6期489-498页
The increased detection of small-sized peripheral non-small-cell lung cancer (NSCLC) has renewed interest in sublobar resection in lieu of lobectomy.
4308. Trial of Endovascular Thrombectomy for Large Ischemic Strokes.
作者: Amrou Sarraj.;Ameer E Hassan.;Michael G Abraham.;Santiago Ortega-Gutierrez.;Scott E Kasner.;M Shazam Hussain.;Michael Chen.;Spiros Blackburn.;Clark W Sitton.;Leonid Churilov.;Sophia Sundararajan.;Yin C Hu.;Nabeel A Herial.;Pascal Jabbour.;Daniel Gibson.;Adam N Wallace.;Juan F Arenillas.;Jenny P Tsai.;Ronald F Budzik.;William J Hicks.;Osman Kozak.;Bernard Yan.;Dennis J Cordato.;Nathan W Manning.;Mark W Parsons.;Ricardo A Hanel.;Amin N Aghaebrahim.;Teddy Y Wu.;Pere Cardona-Portela.;Natalia Pérez de la Ossa.;Joanna D Schaafsma.;Jordi Blasco.;Navdeep Sangha.;Steven Warach.;Chirag D Gandhi.;Timothy J Kleinig.;Daniel Sahlein.;Lucas Elijovich.;Wondwossen Tekle.;Edgar A Samaniego.;Laith Maali.;M Ammar Abdulrazzak.;Marios N Psychogios.;Ashfaq Shuaib.;Deep K Pujara.;Faris Shaker.;Hannah Johns.;Gagan Sharma.;Vignan Yogendrakumar.;Felix C Ng.;Mohammad H Rahbar.;Chunyan Cai.;Philip Lavori.;Scott Hamilton.;Thanh Nguyen.;Johanna T Fifi.;Stephen Davis.;Lawrence Wechsler.;Vitor M Pereira.;Maarten G Lansberg.;Michael D Hill.;James C Grotta.;Marc Ribo.;Bruce C Campbell.;Gregory W Albers.; .
来源: N Engl J Med. 2023年388卷14期1259-1271页
Trials of the efficacy and safety of endovascular thrombectomy in patients with large ischemic strokes have been carried out in limited populations.
4309. Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct.
作者: Xiaochuan Huo.;Gaoting Ma.;Xu Tong.;Xuelei Zhang.;Yuesong Pan.;Thanh N Nguyen.;Guangxiong Yuan.;Hongxing Han.;Wenhuo Chen.;Ming Wei.;Jiangang Zhang.;Zhiming Zhou.;Xiaoxi Yao.;Guoqing Wang.;Weigen Song.;Xueli Cai.;Guangxian Nan.;Di Li.;A Yi-Chou Wang.;Wentong Ling.;Chuwei Cai.;Changming Wen.;En Wang.;Liyong Zhang.;Changchun Jiang.;Yajie Liu.;Geng Liao.;Xiaohui Chen.;Tianxiao Li.;Shudong Liu.;Jinglun Li.;Feng Gao.;Ning Ma.;Dapeng Mo.;Ligang Song.;Xuan Sun.;Xiaoqing Li.;Yiming Deng.;Gang Luo.;Ming Lv.;Hongwei He.;Aihua Liu.;Jingbo Zhang.;Shiqing Mu.;Lian Liu.;Jing Jing.;Ximing Nie.;Zeyu Ding.;Wanliang Du.;Xingquan Zhao.;Pengfei Yang.;Liping Liu.;Yilong Wang.;David S Liebeskind.;Vitor M Pereira.;Zeguang Ren.;Yongjun Wang.;Zhongrong Miao.; .
来源: N Engl J Med. 2023年388卷14期1272-1283页
The role of endovascular therapy for acute stroke with a large infarction has not been extensively studied in differing populations.
4310. Ide-cel or Standard Regimens in Relapsed and Refractory Multiple Myeloma.
作者: Paula Rodriguez-Otero.;Sikander Ailawadhi.;Bertrand Arnulf.;Krina Patel.;Michele Cavo.;Ajay K Nooka.;Salomon Manier.;Natalie Callander.;Luciano J Costa.;Ravi Vij.;Nizar J Bahlis.;Philippe Moreau.;Scott R Solomon.;Michel Delforge.;Jesus Berdeja.;Anna Truppel-Hartmann.;Zhihong Yang.;Linda Favre-Kontula.;Fan Wu.;Julia Piasecki.;Mark Cook.;Sergio Giralt.
来源: N Engl J Med. 2023年388卷11期1002-1014页
Survival is poor among patients with triple-class-exposed relapsed and refractory multiple myeloma. Idecabtagene vicleucel (ide-cel), a B-cell maturation antigen-directed chimeric antigen receptor (CAR) T-cell therapy, previously led to deep, durable responses in patients with heavily pretreated relapsed and refractory multiple myeloma.
4312. Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth.
作者: Alan T N Tita.;Waldemar A Carlo.;Elizabeth M McClure.;Musaku Mwenechanya.;Elwyn Chomba.;Jennifer J Hemingway-Foday.;Avinash Kavi.;Mrityunjay C Metgud.;Shivaprasad S Goudar.;Richard Derman.;Adrien Lokangaka.;Antoinette Tshefu.;Melissa Bauserman.;Carl Bose.;Poonam Shivkumar.;Manju Waikar.;Archana Patel.;Patricia L Hibberd.;Paul Nyongesa.;Fabian Esamai.;Osayame A Ekhaguere.;Sherri Bucher.;Saleem Jessani.;Shiyam S Tikmani.;Sarah Saleem.;Robert L Goldenberg.;Sk M Billah.;Ruth Lennox.;Rashidul Haque.;William Petri.;Lester Figueroa.;Manolo Mazariegos.;Nancy F Krebs.;Janet L Moore.;Tracy L Nolen.;Marion Koso-Thomas.; .
来源: N Engl J Med. 2023年388卷13期1161-1170页
The use of azithromycin reduces maternal infection in women during unplanned cesarean delivery, but its effect on those with planned vaginal delivery is unknown. Data are needed on whether an intrapartum oral dose of azithromycin would reduce maternal and offspring sepsis or death.
4315. Neutralization of BA.4-BA.5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent Vaccine.
作者: Jing Zou.;Chaitanya Kurhade.;Sohil Patel.;Nicholas Kitchin.;Kristin Tompkins.;Mark Cutler.;David Cooper.;Qi Yang.;Hui Cai.;Alexander Muik.;Ying Zhang.;Dung-Yang Lee.;Ugur Şahin.;Annaliesa S Anderson.;William C Gruber.;Xuping Xie.;Kena A Swanson.;Pei-Yong Shi.
来源: N Engl J Med. 2023年388卷9期854-857页 4316. Immunogenicity of a Fourth Homologous Dose of NVX-CoV2373.
作者: Katia Alves.;Joyce S Plested.;Shirley Galbiati.;Gordon Chau.;Shane Cloney-Clark.;Mingzhu Zhu.;Raj Kalkeri.;Nita Patel.;Kathy Smith.;Alex Marcheschi.;Susan Pfeiffer.;Heather McFall.;Gale Smith.;Gregory M Glenn.;Filip Dubovsky.;Raburn M Mallory.; .
来源: N Engl J Med. 2023年388卷9期857-859页 |