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4281. Comparing Colon Capsule Endoscopy to colonoscopy; a symptomatic patient's perspective.
Colon Capsule Endoscopy (CCE) has proven efficacy in a variety of gastrointestinal diseases. Few studies have assessed patient-reported outcomes and preference between colonoscopy and CCE.
4283. Predicting Pancreatic Cancer in the UK Biobank Cohort Using Polygenic Risk Scores and Diabetes Mellitus.
作者: Shreya Sharma.;William J Tapper.;Andrew Collins.;Zaed Z R Hamady.
来源: Gastroenterology. 2022年162卷6期1665-1674.e2页
Diabetes mellitus (DM) is known to be associated with pancreatic ductal adenocarcinoma (PDAC), particularly new-onset DM (NODM). Others have developed polygenic risk scores (PRS) associated with PDAC risk. We aimed to compare the performance of these PRS in an independent cohort to determine if they can discriminate between NODM and long-standing DM patients with PDAC.
4285. MS275 as Class I HDAC inhibitor displayed therapeutic potential on malignant ascites by iTRAQ-based quantitative proteomic analysis.
作者: Li Du.;Dongyuan Wang.;Xiuqi Wei.;Chang Liu.;Zhuanglong Xiao.;Wei Qian.;Yuhu Song.;Xiaohua Hou.
来源: BMC Gastroenterol. 2022年22卷1期29页
Malignant ascites is a manifestation of end stage events in a variety of cancers and is associated with significant morbidity. Epigenetic modulators play a key role in cancer initiation and progression, among which histone deacetylases (HDACs) are considered as one of the most important regulators for various cancer development, such as liver cancer, ovarian cancer, and pancreatic cancer et al. Thus, in this paper, we sought to explore the therapeutic effect of HDAC inhibitor on malignant ascites.
4286. Deep muscularis propria tumor invasion without lymph node metastasis as a unique subclassification of stage IB gastric cancer: a retrospective study.
作者: Kang He.;Cheng Chen.;Lei Xia.;Lixiang Si.;Xiaohua Pan.;Zijian Sun.;Yajing Wang.;Yingying Jiang.;Yue Shi.;Bin Zhou.;Shuaiyu Wang.;Jing Han.;Bo Shen.;Guoren Zhou.;Jianwei Lu.;Xiaohua Wang.
来源: BMC Gastroenterol. 2022年22卷1期30页
The prognosis difference based on the depth of tumor muscularis propria invasion in gastric cancer (GC) was still debated, and therapy strategy for stage IB GC patient required further investigation.
4287. Malignant rhabdoid tumor of the liver in a middle-aged woman: a case report and literature review.
Extrarenal malignant rhabdoid tumor (EMRT) is a rare and high-mortality malignant tumor, which is more common in infants and rarely seen in adults. We firstly report a case of liver malignant rhabdoid tumor (MRT) with a loss of SMARCB1 gene (alias INI1, SNF5, BAF47) expression in a middle-aged woman, and preliminarily summarize the clinical characteristics and discuss its potential treatment of liver MRT by reviewing 55 cases reported in the past.
4288. Near-infrared fluorescence imaging with indocyanine green for assessment of donor livers in a rat model of ischemia-reperfusion.
作者: Liyu Shan.;Huan Chen.;Lifei Yang.;Zhe Feng.;Yue Wang.;Rongfeng Wang.;Nana Zhang.;Rongqian Wu.;Yi Lv.;Tao Ma.
来源: BMC Gastroenterol. 2022年22卷1期27页
Although marginal donor livers expand the donor pool, an ideal method for quantitatively evaluating the quality of donor livers has not been developed. This study aimed to explore the feasibility of indocyanine green (ICG) fluorescence imaging for estimating liver function in an ischemia-reperfusion model.
4289. PADI4 promotes epithelial-mesenchymal transition(EMT) in gastric cancer via the upregulation of interleukin 8.
作者: Xiao-Tian Chang.;Hui Wu.;Hui-Lin Li.;Hong-Lei Li.;Ya-Bing Zheng.
来源: BMC Gastroenterol. 2022年22卷1期25页
Gastric cancer (GC) is one of the deadliest tumours due to its ability to metastasize. The Epithelial-to-mesenchymal transition plays a crucial role in promoting the GC metastasis, which increases the migration and metastasis of tumour cells. Peptidyl arginine deiminase IV (PADI4) is a susceptibility gene for gastric carcinoma. The aim of this study was to evaluate the functional roles of PADI4 in gastric cancer.
4290. Serum creatinine/cystatin C ratio as a surrogate marker for sarcopenia in patients with gastric cancer.
作者: Jing Sun.;Hui Yang.;Wentao Cai.;Jingwei Zheng.;Ningzhe Shen.;Xinxin Yang.;Bujian Pan.;Weiteng Zhang.;Xiaodong Chen.;Xian Shen.
来源: BMC Gastroenterol. 2022年22卷1期26页
Sarcopenia is an age-related syndrome that may have negative impact on surgical outcomes and long-term survival of patients with gastric cancer. Serum creatinine/cystatin C (Cr/CysC) ratio has attracted attention as a surrogate marker for sarcopenia but has not been adequately studied in patients with gastric cancer. The purpose of this study was to investigate the validity of serum Cr/CysC ratio as a predictor of sarcopenia, evaluate a statistical cut-off value, and assess the relationship between Cr/CysC ratio and prognosis of patients with gastric cancer.
4291. Intestinal Claudin-7 deficiency impacts the intestinal microbiota in mice with colitis.
作者: Yuhan Ding.;Kun Wang.;Chang Xu.;Mengdi Hao.;Huimin Li.;Lei Ding.
来源: BMC Gastroenterol. 2022年22卷1期24页
Intestinal epithelial cells form a physical barrier that protects the intestine against the intestinal microbiota through tight junctions (TJs) and adhesive junctions, while barrier disruption may lead to inflammatory bowel disease (IBD). Claudin-7 (Cldn7) has been implicated in this protection as an important member of TJs. Here, we experimentally study the effect of Cldn7 deletion on intestinal microbiota in colitis.
4293. Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive autoimmune hepatitis.
作者: Qingling Chen.;Min Gao.;Hang Yang.;Ling Mei.;Rui Zhong.;Ping Han.;Peiyan Liu.;Lili Zhao.;Jing Wang.;Jia Li.
来源: BMC Gastroenterol. 2022年22卷1期23页
The association between iron-metabolism-related variables and liver fibrosis in chronic hepatitis C and nonalcoholic fatty liver disease is now well known. However, the relationship has not been extensively studied in autoimmune hepatitis (AIH). We aimed to investigate the association between variables associated with iron metabolism and advanced liver fibrosis among untreated patients with AIH.
4294. Induction of remission with tacrolimus in a patient with severe acute, cortisone refractory ulcerative colitis and severe Covid-19 pneumonia: a case report.
作者: Lisanne Rieker.;Johannes Hofer.;Golo Petzold.;Volker Ellenrieder.;Ahmad Amanzada.
来源: BMC Gastroenterol. 2022年22卷1期22页
Therapy regimens used in patients with inflammatory Bowel Disease (IBD) have been associated with enhanced risk of viral infections or viral reactivation. Moreover, it is uncertain whether IBD patients have increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or infected patients may have an increased risk for severe coronavirus disease 2019 (Covid-19). Managing severe acute flare in ulcerative colitis during the Covid-19 pandemic is a challenge for clinicians and their patients. The results of the published studies mainly report on the role of the prior medication, but not how to treat severe acute flare of IBD patients with severe Covid-19 pneumonia.
4295. Strategies for discontinuation of proton pump inhibitors (PPIs) in patients with long-term PPI administration: a randomized controlled trial.
作者: Mariko Hojo.;Daisuke Asaoka.;Yuji Shimada.;Shuko Nojiri.;Akihito Nagahara.
来源: BMC Gastroenterol. 2022年22卷1期21页
Proton pump inhibitors (PPIs), including potassium ion-competitive acid blocker, are widely used worldwide and are often used for long periods of time. However, in recent years, potential side effects associated with long-term PPI use have been reported. Many patients take PPI for a long period of time, even though it is unnecessary, and it is necessary to discontinue PPI administration in such patients. However, sudden discontinuation may cause symptoms to recur and discontinuation may be unsuccessful. A strategy for safe and secure PPI discontinuation has not yet been established. The purpose of this study is to determine whether PPI can be safely discontinued by tapering the PPI dose or by abrupt discontinuation of PPI, and to establish a strategy for safe and secure PPI discontinuation.
4298. Gestational Insulin Resistance Is Mediated by the Gut Microbiome-Indoleamine 2,3-Dioxygenase Axis.
作者: Medha Priyadarshini.;Guadalupe Navarro.;Derek J Reiman.;Anukriti Sharma.;Kai Xu.;Kristen Lednovich.;Christopher R Manzella.;Md Wasim Khan.;Mariana Salas Garcia.;Sarah Allard.;Barton Wicksteed.;George E Chlipala.;Barbara Szynal.;Beatriz Penalver Bernabe.;Pauline M Maki.;Ravinder K Gill.;Gary H Perdew.;Jack Gilbert.;Yang Dai.;Brian T Layden.
来源: Gastroenterology. 2022年162卷6期1675-1689.e11页
Normal gestation involves a reprogramming of the maternal gut microbiome (GM) that contributes to maternal metabolic changes by unclear mechanisms. This study aimed to understand the mechanistic underpinnings of the GM-maternal metabolism interaction.
4299. Toll-Like Receptor 1 Locus Re-examined in a Genome-Wide Association Study Update on Anti-Helicobacter pylori IgG Titers.
作者: Suk Yee Lam.;Michiel C Mommersteeg.;Bingting Yu.;Linda Broer.;Manon C W Spaander.;Fabian Frost.;Stefan Weiss.;Henry Völzke.;Markus M Lerch.;Ben Schöttker.;Yan Zhang.;Hannah Stocker.;Hermann Brenner.;Daniel Levy.;Shih-Jen Hwang.;Alexis C Wood.;Stephen S Rich.;Jerome I Rotter.;Kent D Taylor.;Russell P Tracy.;Edmond K Kabagambe.;Marcis Leja.;Janis Klovins.;Raitis Peculis.;Dace Rudzite.;Liene Nikitina-Zake.;Girts Skenders.;Vita Rovite.;André Uitterlinden.;Ernst J Kuipers.;Gwenny M Fuhler.;Georg Homuth.;Maikel P Peppelenbosch.
来源: Gastroenterology. 2022年162卷6期1705-1715页
A genome-wide significant association between anti-Helicobacter pylori (H pylori) IgG titers and Toll-like receptor (TLR1/6/10) locus on 4p14 was demonstrated for individuals of European ancestry, but not uniformly replicated. We re-investigated this association in an updated genome-wide association study (GWAS) meta-analysis for populations with low gastric cancer incidence, address potential causes of cohort heterogeneity, and explore functional implications of genetic variation at the TLR1/6/10 locus.
4300. PUFA-Induced Metabolic Enteritis as a Fuel for Crohn's Disease.
作者: Julian Schwärzler.;Lisa Mayr.;Arnau Vich Vila.;Felix Grabherr.;Lukas Niederreiter.;Maureen Philipp.;Christoph Grander.;Moritz Meyer.;Almina Jukic.;Simone Tröger.;Barbara Enrich.;Nicole Przysiecki.;Markus Tschurtschenthaler.;Felix Sommer.;Irmgard Kronberger.;Jakob Koch.;Richard Hilbe.;Michael W Hess.;Georg Oberhuber.;Susanne Sprung.;Qitao Ran.;Robert Koch.;Maria Effenberger.;Nicole C Kaneider.;Verena Wieser.;Markus A Keller.;Rinse K Weersma.;Konrad Aden.;Philip Rosenstiel.;Richard S Blumberg.;Arthur Kaser.;Herbert Tilg.;Timon E Adolph.
来源: Gastroenterology. 2022年162卷6期1690-1704页
Crohn's disease (CD) globally emerges with Westernization of lifestyle and nutritional habits. However, a specific dietary constituent that comprehensively evokes gut inflammation in human inflammatory bowel diseases remains elusive. We aimed to delineate how increased intake of polyunsaturated fatty acids (PUFAs) in a Western diet, known to impart risk for developing CD, affects gut inflammation and disease course. We hypothesized that the unfolded protein response and antioxidative activity of glutathione peroxidase 4 (GPX4), which are compromised in human CD epithelium, compensates for metabolic perturbation evoked by dietary PUFAs.
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