4281. Evaluation of BNT162b2 Covid-19 Vaccine in Children Younger than 5 Years of Age.
作者: Flor M Muñoz.;Lawrence D Sher.;Charu Sabharwal.;Alejandra Gurtman.;Xia Xu.;Nicholas Kitchin.;Stephen Lockhart.;Robert Riesenberg.;Joanna M Sexter.;Hanna Czajka.;Grant C Paulsen.;Yvonne Maldonado.;Emmanuel B Walter.;Kawsar R Talaat.;Janet A Englund.;Uzma N Sarwar.;Caitlin Hansen.;Martha Iwamoto.;Chris Webber.;Luke Cunliffe.;Benita Ukkonen.;Silvina N Martínez.;Barbara A Pahud.;Iona Munjal.;Joseph B Domachowske.;Kena A Swanson.;Hua Ma.;Kenneth Koury.;Susan Mather.;Claire Lu.;Jing Zou.;Xuping Xie.;Pei-Yong Shi.;David Cooper.;Özlem Türeci.;Uğur Şahin.;Kathrin U Jansen.;William C Gruber.; .
来源: N Engl J Med. 2023年388卷7期621-634页
Safe and effective vaccines against coronavirus disease 2019 (Covid-19) are urgently needed in young children.
4282. Efficacy and Safety of an Ad26.RSV.preF-RSV preF Protein Vaccine in Older Adults.
作者: Ann R Falsey.;Kristi Williams.;Efi Gymnopoulou.;Stephan Bart.;John Ervin.;Arangassery R Bastian.;Joris Menten.;Els De Paepe.;Sjouke Vandenberghe.;Eric K H Chan.;Jerald Sadoff.;Macaya Douoguih.;Benoit Callendret.;Christy A Comeaux.;Esther Heijnen.; .
来源: N Engl J Med. 2023年388卷7期609-620页
Respiratory syncytial virus (RSV) can cause serious lower respiratory tract disease in older adults, but no licensed RSV vaccine currently exists. An adenovirus serotype 26 RSV vector encoding a prefusion F (preF) protein (Ad26.RSV.preF) in combination with RSV preF protein was previously shown to elicit humoral and cellular immunogenicity.
4283. Respiratory Syncytial Virus Prefusion F Protein Vaccine in Older Adults.
作者: Alberto Papi.;Michael G Ison.;Joanne M Langley.;Dong-Gun Lee.;Isabel Leroux-Roels.;Federico Martinon-Torres.;Tino F Schwarz.;Richard N van Zyl-Smit.;Laura Campora.;Nancy Dezutter.;Nathalie de Schrevel.;Laurence Fissette.;Marie-Pierre David.;Marie Van der Wielen.;Lusine Kostanyan.;Veronica Hulstrøm.; .
来源: N Engl J Med. 2023年388卷7期595-608页
Respiratory syncytial virus (RSV) is an important cause of acute respiratory infection, lower respiratory tract disease, clinical complications, and death in older adults. There is currently no licensed vaccine against RSV infection.
4284. Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer.
作者: Ian H Kunkler.;Linda J Williams.;Wilma J L Jack.;David A Cameron.;J Michael Dixon.
来源: N Engl J Med. 2023年388卷7期585-594页
Limited level 1 evidence is available on the omission of radiotherapy after breast-conserving surgery in older women with hormone receptor-positive early breast cancer receiving adjuvant endocrine therapy.
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