4261. Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomised, double-blind, multicentre, phase 2b-3 trial.
作者: Brett King.;Xingqi Zhang.;Walter Gubelin Harcha.;Jacek C Szepietowski.;Jerry Shapiro.;Charles Lynde.;Natasha A Mesinkovska.;Samuel H Zwillich.;Lynne Napatalung.;Dalia Wajsbrot.;Rana Fayyad.;Amy Freyman.;Debanjali Mitra.;Vivek Purohit.;Rodney Sinclair.;Robert Wolk.
来源: Lancet. 2023年401卷10387期1518-1529页
Alopecia areata is characterised by non-scarring loss of scalp, face, or body hair. We investigated the efficacy and safety of ritlecitinib, an oral, selective dual JAK3/TEC family kinase inhibitor, in patients with alopecia areata.
4266. Anthracycline-containing and taxane-containing chemotherapy for early-stage operable breast cancer: a patient-level meta-analysis of 100 000 women from 86 randomised trials.
Anthracycline-taxane chemotherapy for early-stage breast cancer substantially improves survival compared with no chemotherapy. However, concerns about short-term and long-term side-effects of anthracyclines have led to increased use of taxane chemotherapy without anthracycline, which could compromise efficacy. We aimed to better characterise the benefits and risks of including anthracycline, and the comparative benefits of different anthracycline-taxane regimens.
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