4266. Single-Cell DNA Sequencing Reveals Punctuated and Gradual Clonal Evolution in Hepatocellular Carcinoma.
作者: Lin Guo.;Xianfu Yi.;Lu Chen.;Ti Zhang.;Hua Guo.;Ziye Chen.;Jinghui Cheng.;Qi Cao.;Hengkang Liu.;Chunyu Hou.;Lisha Qi.;Zhiyan Zhu.;Yucun Liu.;Ruirui Kong.;Chong Zhang.;Xiaohua Zhou.;Zemin Zhang.;Tianqiang Song.;Ruidong Xue.;Ning Zhang.
来源: Gastroenterology. 2022年162卷1期238-252页
Copy number alterations (CNAs), elicited by genome instability, are a major source of intratumor heterogeneity. How CNAs evolve in hepatocellular carcinoma (HCC) remains unknown.
4271. High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites.
作者: Jia Yang.;Hong Wei.;Yunfei Zhou.;Chun-Ho Szeto.;Chuangen Li.;Yufeng Lin.;Olabisi O Coker.;Harry Cheuk Hay Lau.;Anthony W H Chan.;Joseph J Y Sung.;Jun Yu.
来源: Gastroenterology. 2022年162卷1期135-149.e2页
Dietary fat intake is associated with increased risk of colorectal cancer (CRC). We examined the role of high-fat diet (HFD) in driving CRC through modulating gut microbiota and metabolites.
4273. Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development Defects.
作者: Taida Huang.;Yonghui Hou.;Xia Wang.;Liang Wang.;Chenju Yi.;Cuifang Wang.;Xiaoyun Sun.;Paul K H Tam.;Sai Ming Ngai.;Mai Har Sham.;Alan J Burns.;Wood Yee Chan.
来源: Gastroenterology. 2022年162卷1期179-192.e11页
The enteric nervous system, which regulates many gastrointestinal functions, is derived from neural crest cells (NCCs). Defective NCC migration during embryonic development may lead to enteric neuropathies such as Hirschsprung's disease (hindgut aganglionosis). Sox10 is known to be essential for cell migration but downstream molecular events regulating early NCC migration have not been fully elucidated. This study aimed to determine how Sox10 regulates migration of sacral NCCs toward the hindgut using Dominant megacolon mice, an animal model of Hirschsprung's disease with a Sox10 mutation.
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