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4241. Higher vs Standard Adalimumab Induction Dosing Regimens and Two Maintenance Strategies: Randomized SERENE CD Trial Results.
作者: Geert R D'Haens.;William J Sandborn.;Edward V Loftus.;Stephen B Hanauer.;Stefan Schreiber.;Laurent Peyrin-Biroulet.;Remo Panaccione.;Julián Panés.;Filip Baert.;Jean-Frederic Colombel.;Marc Ferrante.;Edouard Louis.;Alessandro Armuzzi.;Qian Zhou.;Venkata S Goteti.;Nael M Mostafa.;Thao T Doan.;Joel Petersson.;Tricia Finney-Hayward.;Alexandra P Song.;Anne M Robinson.;Silvio Danese.
来源: Gastroenterology. 2022年162卷7期1876-1890页
Dose-optimization strategies for biologic therapies in Crohn's disease (CD) are not well established. The SERENE CD (Study of a Novel Approach to Induction and Maintenance Dosing With Adalimumab in Patients With Moderate to Severe Crohn's Disease) trial evaluated higher vs standard adalimumab induction dosing and clinically adjusted (CA) vs therapeutic drug monitoring (TDM) maintenance strategies in patients with moderately to severely active CD.
4246. Diminished Piezo2-Dependent Tactile Sensitivity Occurs in Aging Human Gut and Slows Gastrointestinal Transit in Mice.
作者: Lauren A Jones.;Byungchang Jin.;Alyce M Martin.;Lai Wei.; .;Seungil Ro.;Damien J Keating.
来源: Gastroenterology. 2022年162卷6期1755-1757.e2页 4256. Factors affecting the use of herbal products in patients with Irritable Bowel Syndrome and their results: case-control study.
作者: Emin Gemcioglu.;Nuray Yılmaz Cakmak.;Salih Baser.;Servet Kocaoz.;Osman Ersoy.
来源: BMC Gastroenterol. 2022年22卷1期43页
Irritable bowel syndrome (IBS) is a functional bowel disease that is characterized by abdominal pain, discomfort, and changes in the frequency and form of stool without any organic pathology. In this study, the factors that affect the herbal treatment choices of IBS patients and their results were investigated.
4257. Indicators of suboptimal response to anti-tumor necrosis factor therapy in patients from China with inflammatory bowel disease: results from the EXPLORE study.
作者: Ji Li.;Zhanju Liu.;Pinjin Hu.;Zhonghui Wen.;Qian Cao.;Xiaoping Zou.;Yan Chen.;Yingde Wang.;Jie Zhong.;Xizhong Shen.;Dirk Demuth.;Olga Fadeeva.;Li Xie.;Jun Chen.;Jiaming Qian.
来源: BMC Gastroenterol. 2022年22卷1期44页
Prevalence of inflammatory bowel disease (IBD) is increasing in China. The EXPLORE study evaluated the incidence and indicators of suboptimal responses to first-line anti-tumor necrosis factor (TNF) in patients with ulcerative colitis (UC) or Crohn's disease (CD). We present results for the mainland China subgroup.
4258. Inflammatory cloacogenic polyps in children: diagnostic yield of rectal retroflexion during colonoscopy.
Inflammatory cloacogenic polyps (ICPs) are inflammatory lesions occurring around the anal transitional zone. These are rare in the pediatric population, and most reported cases are found in adults. Therefore, this study aimed to evaluate the usefulness of rectal retroflexion (RR) during colonoscopy in detecting ICPs in children.
4259. Nonthyroidal illness syndrome in acute pancreatitis patients: an 8-year cohort study.
作者: Cheng Qu.;Zehua Duan.;Xiaojia Xiao.;Mei Wei.;Kun Gao.;Xianqiang Yu.;Lu Ke.;Zhihui Tong.;Weiqin Li.
来源: BMC Gastroenterol. 2022年22卷1期40页
Nonthyroidal illness syndrome (NTIS) is common in critical illness and is associated with poor prognosis. The aim of this study was to find the prevalence, charateristics, and prognosis of NTIS and its correlation with outcomes in AP patients.
4260. "One-step" approach versus "Step-up" approach minimally invasive treatment for infected pancreatic necrosis: a study protocol for a single-center, prospective, randomized controlled trial.
作者: Zhi Zheng.;Jiongdi Lu.;Feng Cao.;Yixuan Ding.;Yulin Guo.;Wentong Mei.;Yuanxu Qu.;Shuang Liu.;Haichen Sun.;Yeqing Cui.;Ang Li.;Fei Li.
来源: BMC Gastroenterol. 2022年22卷1期41页
Currently, the minimally invasive "Step-up" surgical strategy is still the main treatment for infected pancreatic necrosis (IPN). However, indiscriminate implementation of the "Step-up" strategy can lead to increased numbers of operations and prolonged hospital stay. The "Step-up" approach is not appropriate for some patients due to unavailabilty of a safe puncture path. Therefore, we developed the "One-step" surgical approach to treat IPN, which is safety. However, there is still a lack of comparison of the short and long-term efficacy between the "One-step" and "Step-up" approach. Consequently, we are conducting this clinical trial to provide a reference for IPN treatment.
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