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4201. Subclinical atherosclerosis profiles in rheumatoid arthritis and primary Sjögren's syndrome: the impact of BAFF genetic variations.
作者: Nikolaos Kintrilis.;Fotini Gravani.;Anna Rapti.;Myrto Papaioannou.;Christina-Maria Flessa.;Adrianos Nezos.;Eleni Antypa.;Ioanna Papadaki.;Τheofanis Karageorgas.;Haralampos M Moutsopoulos.;Clio P Mavragani.
来源: Rheumatology (Oxford). 2023年62卷2期958-968页
RA and primary SS carry increased atherosclerotic risk, while B-cell activating factor holds a vital role in disease pathogenesis and atherosclerosis. We aimed to compare subclinical atherosclerosis profiles between the two clinical entities and define whether BAFF genetic variants alter atherosclerotic risk.
4202. Combined plasma metabolomic and transcriptomic analysis identify histidine as a biomarker and potential contributor in SLE pathogenesis.
作者: Yukiko Iwasaki.;Yusuke Takeshima.;Masahiro Nakano.;Mai Okubo.;Mineto Ota.;Akari Suzuki.;Yuta Kochi.;Tomohisa Okamura.;Takaho Endo.;Ichiro Miki.;Kazuhiro Sakurada.;Kazuhiko Yamamoto.;Keishi Fujio.
来源: Rheumatology (Oxford). 2023年62卷2期905-913页
To investigate metabolite alterations in the plasma of SLE patients to identify novel biomarkers and provide insight into SLE pathogenesis.
4203. L-shaped association between serum 25-hydroxyvitamin D and all-cause mortality of individuals with rheumatoid arthritis.
作者: Bin Cai.;Mengmeng Zhou.;Qingqing Xiao.;Hejian Zou.;Xiaoxia Zhu.
来源: Rheumatology (Oxford). 2023年62卷2期575-582页
We aimed to examine the relationship between serum 25-hydroxyvitamin D and all-cause, cause-specific mortality of patients with RA.
4205. Trajectories of depressive symptoms in systemic lupus erythematosus over time.
作者: Seerat Chawla.;Jiandong Su.;Zahi Touma.;Patricia Katz.
来源: Rheumatology (Oxford). 2023年62卷2期676-684页
The objectives of this study were to determine the trajectories of depressive symptoms in patients with SLE and to identify baseline characteristics that are associated with a patient's trajectory of depression.
4206. The BILAG-2004 index is associated with development of new damage in SLE.
作者: Chee-Seng Yee.;Caroline Gordon.;Mohammed Akil.;Peter Lanyon.;Christopher J Edwards.;David A Isenberg.;Anisur Rahman.;Lee-Suan Teh.;Sofia Tosounidou.;Robert Stevens.;Athiveeraramapandian Prabu.;Bridget Griffiths.;Neil McHugh.;Ian N Bruce.;Yasmeen Ahmad.;Munther A Khamashta.;Vernon T Farewell.
来源: Rheumatology (Oxford). 2023年62卷2期668-675页
To determine whether BILAG-2004 index is associated with the development of damage in a cohort of SLE patients. Mortality and development of damage were examined.
4207. Changes on chest HRCT in systemic sclerosis-related interstitial lung disease after autologous haematopoietic stem cell transplantation.
作者: Grégory Pugnet.;Antoine Petermann.;Samia Collot.;Philippe Otal.;Pauline Lansiaux.;Nassim Ait Abdallah.;Gwenaëlle Lorillon.;Mathieu Resche-Rigon.;Cécile Borel.;Zora Marjanovic.;Dominique Farge.; .
来源: Rheumatology (Oxford). 2023年62卷SI期SI32-SI42页
To evaluate extent of interstitial lung disease (ILD) and oesophageal involvement using high-resolution computed tomography (HRCT) in early diffuse SSc patients after autologous haematopoietic stem cell transplantation (aHSCT).
4208. DNA from macrophages induces fibrosis and vasculopathy through POLR3A/STING/type I interferon axis in systemic sclerosis.
作者: Chaofan Liu.;Jiaxuan Tang.;Wei Luo.;Shiying Liu.;Xiaolei Sun.;Wenxuan Hong.;Xing Zhou.;Jinghao Lu.;Ming Li.;Lubing Zhu.
来源: Rheumatology (Oxford). 2023年62卷2期934-945页
To clarify the role of RNA polymerase III A (POLR3A)/type I IFN in the pathogenesis of SSc.
4209. Severe Libman-Sacks endocarditis complicating antiphospholipid syndrome: a retrospective analysis of 23 operated cases.
作者: Nellie Bourse Chalvon.;Nathalie Costedoat-Chalumeau.;Jean-Loup Pennaforte.;Amelie Servettaz.;Camille Boulagnon Rombi.;Pierre-Edouard Gavand.;Maud Lekieffre.;Veronique Le Guern.;Nathalie Morel.;Fleur Cohen Aubart.;Julien Haroche.;Alexis Mathian.;Jean-Philippe Collet.;Jean-Charles Piette.;Zahir Amoura.;Pauline Orquevaux.
来源: Rheumatology (Oxford). 2023年62卷2期707-715页
Data on severe heart valve disease (HVD), including Libman-Sacks endocarditis, associated with SLE and/or APS requiring valvular surgery are scarce. We thus conducted a retrospective study, aimed at describing and clarifying clinical, laboratory, echocardiographic, histopathological and evolutional features of SLE and/or APS patients with severe associated-HVD.
4210. Anti-phosphatidylserine/prothrombin antibodies and thrombosis associate positively with HLA-DRB1*13 and negatively with HLA-DRB1*03 in SLE.
作者: Sahwa Elbagir.;Lina-Marcela Diaz-Gallo.;Giorgia Grosso.;Agneta Zickert.;Iva Gunnarsson.;Michael Mahler.;Elisabet Svenungsson.;Johan Rönnelid.
来源: Rheumatology (Oxford). 2023年62卷2期924-933页
Emerging evidence demonstrates that aPS-PT associate with thrombotic events. Genetic predisposition, including HLA-DRB1 alleles, is known to contribute to the occurrence of conventional aPL [anti-β2glycoprotein-I (anti-β2GPI) and aCL]. We investigated associations between aPS-PT and HLA-DRB1* alleles and thrombosis in SLE. Conventional aPL were included for comparison.
4211. Impact of lung function and baseline clinical characteristics on patient-reported outcome measures in systemic sclerosis-associated interstitial lung disease.
作者: Michael Kreuter.;Anna-Maria Hoffmann-Vold.;Marco Matucci-Cerinic.;Lesley Ann Saketkoo.;Kristin B Highland.;Hilary Wilson.;Margarida Alves.;Elvira Erhardt.;Nils Schoof.;Toby M Maher.
来源: Rheumatology (Oxford). 2023年62卷SI期SI43-SI53页
The SENSCIS® trial demonstrated a significant reduction of lung function decline in patients with SSc-associated interstitial lung disease (SSc-ILD) treated with nintedanib, but no significant effect on health-related quality of life (HRQoL). To assess whether SSc/SSc-ILD severity and large changes in lung function correlate with HRQoL, a post-hoc analysis of SENSCIS®, aggregating treatment arms, was undertaken.
4212. A new tool supporting the diagnosis of childhood-onset Behçet's disease: venous wall thickness.
作者: Erdal Atalay.;Berna Oguz.;Seher Sener.;H Nursun Ozcan.;Erdal Sag.;Ummusen Kaya Akca.;Muserref Kasap Cuceoglu.;Zeynep Balik.;Jale Karakaya.;Omer Karadag.;Ozge Basaran.;Ezgi Deniz Batu.;Yelda Bilginer.;Seza Ozen.
来源: Rheumatology (Oxford). 2023年62卷SI2期SI181-SI188页
The lower extremity venous wall thickness (VWT) of Behçet's disease (BD) patients was reported to be significantly increased in adults, suggesting its use for the support of BD diagnosis. This prospective study aimed to investigate the lower extremity VWT in childhood-onset definite and incomplete BD patients and compare it to healthy age-matched controls.
4213. Cancer occurrence after SLE: effects of medication-related factors, disease-related factors and survival from an observational study.
作者: Qing Zhao.;Huazhen Liu.;Wenfang Yang.;Ziyue Zhou.;Yiying Yang.;Xu Jiang.;Huaxia Yang.;Fengchun Zhang.
来源: Rheumatology (Oxford). 2023年62卷2期659-667页
To explore the survival and risk factors for cancer occurrence after SLE (SLE-CA).
4214. Improved outcomes in rheumatoid arthritis with obesity after a weight loss intervention: randomized trial.
作者: Veena K Ranganath.;Antonio La Cava.;Sitaram Vangala.;Jenny Brook.;Tanaz A Kermani.;Daniel E Furst.;Mihaela Taylor.;Gurjit S Kaeley.;Catherine Carpenter.;David A Elashoff.;Zhaoping Li.
来源: Rheumatology (Oxford). 2023年62卷2期565-574页
To examine whether a weight loss intervention programme improves RA disease activity and/or musculoskeletal ultrasound synovitis measures in obese RA patients.
4215. Development and psychometric evaluation of the PMR-Impact Scale: a new patient reported outcome measure for polymyalgia rheumatica.
作者: Helen Twohig.;Caroline Mitchell.;Christian D Mallen.;Sara Muller.
来源: Rheumatology (Oxford). 2023年62卷2期758-765页
PMR causes pain, stiffness and disability in older adults. Measuring the impact of the condition from the patient's perspective is vital to high-quality research and patient-centred care, yet there are no validated patient-reported outcome measures (PROMs) for PMR. We set out to develop and psychometrically evaluate a PMR-specific PROM.
4216. Is time a healer? How quality of life changes over time reported by parents of children and young people with juvenile idiopathic arthritis.
作者: Andrew D Smith.;Bishma Saqib.;Rebecca Rachael Lee.;Stephanie Shoop-Worrall.;Kimme L Hyrich.;Janet E McDonagh.;Lis Cordingley.
来源: Rheumatology (Oxford). 2023年62卷2期794-803页
To investigate changes in health-related quality of life (HRQoL) in children and young people with JIA (Juvenile Idiopathic Arthritis) over 3 years following diagnosis.
4217. Pharmacological treatment patterns in patients with juvenile idiopathic arthritis in the Netherlands: a real-world data analysis.
作者: Michelle M A Kip.;Sytze de Roock.;Gillian Currie.;Deborah A Marshall.;Luiza R Grazziotin.;Marinka Twilt.;Rae S M Yeung.;Susanne M Benseler.;Sebastiaan J Vastert.;Nico Wulffraat.;Joost F Swart.;Maarten J IJzerman.
来源: Rheumatology (Oxford). 2023年62卷SI2期SI170-SI180页
To investigate medication prescription patterns among children with JIA, including duration, sequence and reasons for medication discontinuation.
4218. Adipose tissue distribution is associated with cardio-metabolic alterations in adult patients with juvenile-onset dermatomyositis.
作者: Henriette S Marstein.;Birgit N Witczak.;Kristin Godang.;Thomas Schwartz.;Berit Flatø.;Jens Bollerslev.;Ivar Sjaastad.;Helga Sanner.
来源: Rheumatology (Oxford). 2023年62卷SI2期SI196-SI204页
Primary aims were to compare adipose tissue distribution in adult patients with juvenile-onset DM (JDM), with matched controls. Secondary aims were to explore how adipose tissue distribution is associated with cardio-metabolic status (cardiac dysfunction and metabolic syndrome) in patients.
4219. Identification and functional characterization of imbalanced osteoarthritis-associated fibronectin splice variants.
作者: Marcella van Hoolwerff.;Margo Tuerlings.;Imke J L Wijnen.;H Eka D Suchiman.;Davy Cats.;Hailiang Mei.;Rob G H H Nelissen.;Henrike M J van der Linden-van der Zwaag.;Yolande F M Ramos.;Rodrigo Coutinho de Almeida.;Ingrid Meulenbelt.
来源: Rheumatology (Oxford). 2023年62卷2期894-904页
To identify FN1 transcripts associated with OA pathophysiology and investigate the downstream effects of modulating FN1 expression and relative transcript ratio.
4220. Anatomical variation of the sacroiliac joint carries an increased risk for erosion and bone marrow oedema in axial spondyloarthritis.
作者: Katharina Ziegeler.;Sevtap Tugce Ulas.;Denis Poddubnyy.;Fabian Proft.;Valeria Rios Rodriguez.;Judith Rademacher.;Kay Geert A Hermann.;Torsten Diekhoff.
来源: Rheumatology (Oxford). 2023年62卷3期1117-1123页
To assess the impact of joint shape variations on inflammatory lesions on SI joint MRIs in patients with axial spondyloarthritis (axSpA).
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