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4205. An Antigenically Diverse, Representative Panel of Envelope Glycoproteins for Hepatitis C Virus Vaccine Development.
作者: Jordan H Salas.;Richard A Urbanowicz.;Johnathan D Guest.;Nicole Frumento.;Alexis Figueroa.;Kaitlyn E Clark.;Zhenyong Keck.;Vanessa M Cowton.;Sarah J Cole.;Arvind H Patel.;Thomas R Fuerst.;Heidi E Drummer.;Marian Major.;Alexander W Tarr.;Jonathan K Ball.;Mansun Law.;Brian G Pierce.;Steven K H Foung.;Justin R Bailey.
来源: Gastroenterology. 2022年162卷2期562-574页
Development of a prophylactic hepatitis C virus (HCV) vaccine will require accurate and reproducible measurement of neutralizing breadth of vaccine-induced antibodies. Currently available HCV panels may not adequately represent the genetic and antigenic diversity of circulating HCV strains, and the lack of standardization of these panels makes it difficult to compare neutralization results obtained in different studies. Here, we describe the selection and validation of a genetically and antigenically diverse reference panel of 15 HCV pseudoparticles (HCVpps) for neutralization assays.
4209. A Microsatellite in the Coding Sequence of HLA-A/B Is a Mutation Hotspot in Colon Cancer With Microsatellite Instability.
作者: William J Raab.;Arabella Mazzocchi.;Paolo Radice.;Debashis Sahoo.;Chiara Castelli.;Piero Dalerba.; .
来源: Gastroenterology. 2022年162卷3期960-963.e3页 4210. Changes in Metabolic Syndrome Status are Associated With Altered Risk of Pancreatic Cancer: A Nationwide Cohort Study.
作者: Joo-Hyun Park.;Kyungdo Han.;Jung Yong Hong.;Young Suk Park.;Kyu Yeon Hur.;Gunseog Kang.;Joon Oh Park.
来源: Gastroenterology. 2022年162卷2期509-520.e7页
Metabolic syndrome (MetS) is reversible; however, the effect of changes in MetS status on pancreatic cancer risk is unknown. We aimed to investigate the effects of changes and persistence in MetS status on pancreatic cancer risk.
4211. Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma via Autophagy Inhibition, MEK Blockade, and CD40 Agonism.
作者: Honglin Jiang.;Tristan Courau.;Joseph Borison.;Alexa J Ritchie.;Aaron T Mayer.;Matthew F Krummel.;Eric A Collisson.
来源: Gastroenterology. 2022年162卷2期590-603.e14页
Patients with pancreatic ductal adenocarcinoma (PDA) have not yet benefitted from the revolution in cancer immunotherapy due in large part to a dominantly immunosuppressive tumor microenvironment. MEK inhibition combined with autophagy inhibition leads to transient tumor responses in some patients with PDA. We examined the functional effects of combined MEK and autophagy inhibition on the PDA immune microenvironment and the synergy of combined inhibition of MEK and autophagy with CD40 agonism (aCD40) against PDA using immunocompetent model systems.
4212. Incidence and Mortality in Upper Gastrointestinal Cancer After Negative Endoscopy for Gastroesophageal Reflux Disease.
作者: Dag Holmberg.;Giola Santoni.;My Catarina von Euler-Chelpin.;Martti Färkkilä.;Joonas H Kauppila.;John Maret-Ouda.;Eivind Ness-Jensen.;Jesper Lagergren.
来源: Gastroenterology. 2022年162卷2期431-438.e4页
Gastroesophageal reflux disease (GERD) is associated with an increased risk of cancer of the upper gastrointestinal tract. This study aimed to assess whether and to what extent a negative upper endoscopy in patients with GERD is associated with decreased incidence and mortality in upper gastrointestinal cancer (ie, esophageal, gastric, or duodenal cancer).
4213. Host-Microbiota Interactions in the Esophagus During Homeostasis and Allergic Inflammation.
作者: Michael Brusilovsky.;Riyue Bao.;Mark Rochman.;Andrea M Kemter.;Cathryn R Nagler.;Marc E Rothenberg.
来源: Gastroenterology. 2022年162卷2期521-534.e8页
Microbiota composition and mechanisms of host-microbiota interactions in the esophagus are unclear. We aimed to uncover fundamental information about the esophageal microbiome and its potential significance to eosinophilic esophagitis (EoE).
4217. Epidemiology, Etiology, and Treatment of Gastroparesis: Real-World Evidence From a Large US National Claims Database.
作者: Yizhou Ye.;Yu Yin.;Susanna Y Huh.;Cristina Almansa.;Dimitri Bennett.;Michael Camilleri.
来源: Gastroenterology. 2022年162卷1期109-121.e5页
Although gastroparesis carries a considerable health care and patient burden, associated epidemiological data are limited. To provide new real-world evidence for gastroparesis, we estimated disease prevalence, and investigated patient demographics and disease etiology in a large US claims database.
4218. Transferable Immunoglobulin A-Coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation.
作者: Svetlana F Lima.;Lasha Gogokhia.;Monica Viladomiu.;Lance Chou.;Gregory Putzel.;Wen-Bing Jin.;Silvia Pires.;Chun-Jun Guo.;Ylaine Gerardin.;Carl V Crawford.;Vinita Jacob.;Ellen Scherl.;Su-Ellen Brown.;John Hambor.;Randy S Longman.
来源: Gastroenterology. 2022年162卷1期166-178页
Fecal microbiota transplantation (FMT) is an emerging treatment modality for ulcerative colitis (UC). Several randomized controlled trials have shown efficacy for FMT in the treatment of UC, but a better understanding of the transferable microbiota and their immune impact is needed to develop more efficient microbiome-based therapies for UC.
4219. Serologic Response to Coronavirus Disease 2019 (COVID-19) Vaccination in Patients With Immune-Mediated Inflammatory Diseases: A Systematic Review and Meta-analysis.
Patients with immune-mediated inflammatory diseases (IMIDs) have an increased risk of coronavirus disease 2019 (COVID-19), primarily attributed to the use of immunosuppressive drugs such as glucocorticoids, which may attenuate the response to vaccines. This meta-analysis assessed the serologic response to COVID-19 vaccination in patients with IMIDs.
4220. Epithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis.
作者: Lina Welz.;Nassim Kakavand.;Xiang Hang.;Georg Laue.;Go Ito.;Miguel Gomes Silva.;Christina Plattner.;Neha Mishra.;Felicitas Tengen.;Christoph Ogris.;Moritz Jesinghaus.;Felix Wottawa.;Philipp Arnold.;Leena Kaikkonen.;Stefanie Stengel.;Florian Tran.;Saumya Das.;Arthur Kaser.;Zlatko Trajanoski.;Richard Blumberg.;Christoph Roecken.;Dieter Saur.;Markus Tschurtschenthaler.;Stefan Schreiber.;Philip Rosenstiel.;Konrad Aden.
来源: Gastroenterology. 2022年162卷1期223-237.e11页
Throughout life, the intestinal epithelium undergoes constant self-renewal from intestinal stem cells. Together with genotoxic stressors and failing DNA repair, this self-renewal causes susceptibility toward malignant transformation. X-box binding protein 1 (XBP1) is a stress sensor involved in the unfolded protein response (UPR). We hypothesized that XBP1 acts as a signaling hub to regulate epithelial DNA damage responses.
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