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4181. Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors.
作者: Mrinal Gounder.;Ravin Ratan.;Thierry Alcindor.;Patrick Schöffski.;Winette T van der Graaf.;Breelyn A Wilky.;Richard F Riedel.;Allison Lim.;L Mary Smith.;Stephanie Moody.;Steven Attia.;Sant Chawla.;Gina D'Amato.;Noah Federman.;Priscilla Merriam.;Brian A Van Tine.;Bruno Vincenzi.;Charlotte Benson.;Nam Quoc Bui.;Rashmi Chugh.;Gabriel Tinoco.;John Charlson.;Palma Dileo.;Lee Hartner.;Lore Lapeire.;Filomena Mazzeo.;Emanuela Palmerini.;Peter Reichardt.;Silvia Stacchiotti.;Howard H Bailey.;Melissa A Burgess.;Gregory M Cote.;Lara E Davis.;Hari Deshpande.;Hans Gelderblom.;Giovanni Grignani.;Elizabeth Loggers.;Tony Philip.;Joseph G Pressey.;Shivaani Kummar.;Bernd Kasper.
来源: N Engl J Med. 2023年388卷10期898-912页
Desmoid tumors are rare, locally aggressive, highly recurrent soft-tissue tumors without approved treatments.
4184. An Mpox-Related Death in the United States.
作者: Jemma Alarcón.;Moon Kim.;Dawn Terashita.;Kusha Davar.;Jacob M Garrigues.;Jack P Guccione.;Mark G Evans.;Peera Hemarajata.;Noah Wald-Dickler.;Paul Holtom.;Rodrigo Garcia Tome.;Lovelyn Anyanwu.;Naman K Shah.;Matthew Miller.;Todd Smith.;Audrey Matheny.;Whitni Davidson.;Christina L Hutson.;Jonathan Lucas.;Odey C Ukpo.;Nicole M Green.;Sharon E Balter.
来源: N Engl J Med. 2023年388卷13期1246-1247页 4185. Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension.
作者: Marius M Hoeper.;David B Badesch.;H Ardeschir Ghofrani.;J Simon R Gibbs.;Mardi Gomberg-Maitland.;Vallerie V McLaughlin.;Ioana R Preston.;Rogerio Souza.;Aaron B Waxman.;Ekkehard Grünig.;Grzegorz Kopeć.;Gisela Meyer.;Karen M Olsson.;Stephan Rosenkranz.;Yayun Xu.;Barry Miller.;Marcie Fowler.;John Butler.;Joerg Koglin.;Janethe de Oliveira Pena.;Marc Humbert.; .
来源: N Engl J Med. 2023年388卷16期1478-1490页
Pulmonary arterial hypertension is a progressive disease involving proliferative remodeling of the pulmonary vessels. Despite therapeutic advances, the disease-associated morbidity and mortality remain high. Sotatercept is a fusion protein that traps activins and growth differentiation factors involved in pulmonary arterial hypertension.
4188. Five-Year Follow-up after Transcatheter Repair of Secondary Mitral Regurgitation.
作者: Gregg W Stone.;William T Abraham.;JoAnn Lindenfeld.;Saibal Kar.;Paul A Grayburn.;D Scott Lim.;Jacob M Mishell.;Brian Whisenant.;Michael Rinaldi.;Samir R Kapadia.;Vivek Rajagopal.;Ian J Sarembock.;Andreas Brieke.;Steven O Marx.;David J Cohen.;Federico M Asch.;Michael J Mack.; .
来源: N Engl J Med. 2023年388卷22期2037-2048页
Data from a 5-year follow-up of outcomes after transcatheter edge-to-edge repair of severe mitral regurgitation, as compared with outcomes after maximal doses of guideline-directed medical therapy alone, in patients with heart failure are now available.
4190. Transcatheter Repair for Patients with Tricuspid Regurgitation.
作者: Paul Sorajja.;Brian Whisenant.;Nadira Hamid.;Hursh Naik.;Raj Makkar.;Peter Tadros.;Matthew J Price.;Gagan Singh.;Neil Fam.;Saibal Kar.;Jonathan G Schwartz.;Shamir Mehta.;Richard Bae.;Nishant Sekaran.;Travis Warner.;Moody Makar.;George Zorn.;Erin M Spinner.;Phillip M Trusty.;Raymond Benza.;Ulrich Jorde.;Patrick McCarthy.;Vinod Thourani.;Gilbert H L Tang.;Rebecca T Hahn.;David H Adams.; .
来源: N Engl J Med. 2023年388卷20期1833-1842页
Severe tricuspid regurgitation is a debilitating condition that is associated with substantial morbidity and often with poor quality of life. Decreasing tricuspid regurgitation may reduce symptoms and improve clinical outcomes in patients with this disease.
4194. Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients.
作者: Steven E Nissen.;A Michael Lincoff.;Danielle Brennan.;Kausik K Ray.;Denise Mason.;John J P Kastelein.;Paul D Thompson.;Peter Libby.;Leslie Cho.;Jorge Plutzky.;Harold E Bays.;Patrick M Moriarty.;Venu Menon.;Diederick E Grobbee.;Michael J Louie.;Chien-Feng Chen.;Na Li.;LeAnne Bloedon.;Paula Robinson.;Maggie Horner.;William J Sasiela.;Jackie McCluskey.;Deborah Davey.;Pedro Fajardo-Campos.;Predrag Petrovic.;Jan Fedacko.;Witold Zmuda.;Yury Lukyanov.;Stephen J Nicholls.; .
来源: N Engl J Med. 2023年388卷15期1353-1364页
Bempedoic acid, an ATP citrate lyase inhibitor, reduces low-density lipoprotein (LDL) cholesterol levels and is associated with a low incidence of muscle-related adverse events; its effects on cardiovascular outcomes remain uncertain.
4195. Intravascular Imaging-Guided or Angiography-Guided Complex PCI.
作者: Joo Myung Lee.;Ki Hong Choi.;Young Bin Song.;Jong-Young Lee.;Seung-Jae Lee.;Sang Yeub Lee.;Sang Min Kim.;Kyeong Ho Yun.;Jae Young Cho.;Chan Joon Kim.;Hyo-Suk Ahn.;Chang-Wook Nam.;Hyuck-Jun Yoon.;Yong Hwan Park.;Wang Soo Lee.;Jin-Ok Jeong.;Pil Sang Song.;Joon-Hyung Doh.;Sang-Ho Jo.;Chang-Hwan Yoon.;Min Gyu Kang.;Jin-Sin Koh.;Kwan Yong Lee.;Young-Hyo Lim.;Yun-Hyeong Cho.;Jin-Man Cho.;Woo Jin Jang.;Kook-Jin Chun.;David Hong.;Taek Kyu Park.;Jeong Hoon Yang.;Seung-Hyuk Choi.;Hyeon-Cheol Gwon.;Joo-Yong Hahn.; .
来源: N Engl J Med. 2023年388卷18期1668-1679页
Data regarding clinical outcomes after intravascular imaging-guided percutaneous coronary intervention (PCI) for complex coronary-artery lesions, as compared with outcomes after angiography-guided PCI, are limited.
4198. Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression.
作者: Eric J Lenze.;Benoit H Mulsant.;Steven P Roose.;Helen Lavretsky.;Charles F Reynolds.;Daniel M Blumberger.;Patrick J Brown.;Pilar Cristancho.;Alastair J Flint.;Marie A Gebara.;Torie R Gettinger.;Emily Lenard.;J Philip Miller.;Ginger E Nicol.;Hanadi A Oughli.;Vy T Pham.;Bruce L Rollman.;Lei Yang.;Jordan F Karp.
来源: N Engl J Med. 2023年388卷12期1067-1079页
The benefits and risks of augmenting or switching antidepressants in older adults with treatment-resistant depression have not been extensively studied.
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