Postoperative peritoneal adhesion (PA), a prevalent complication of abdominal surgery, arises from aberrant healing of the injured peritoneum. This process involves mesothelial cell trans-differentiation into myofibroblast-like cells, driving peritoneal matrix remodeling and pathological fibrous band formation between organs. Existing therapeutic strategies to prevent PA exhibit limited efficacy, underscoring the need for previously unrecognized mechanistic insights into PA pathogenesis. Here, we elucidate the role of autophagy in mesothelial cell transition and PA development. Utilizing a murine PA model coupled with comprehensive in vitro analyses, we demonstrate that HMGB1-mediated autophagy facilitates TGF-β mediated mesothelial cell trans-differentiation. Specifically, autophagic degradation of E-cadherin counteracts TGF-β-driven mesothelial transition. Pharmacological activation of autophagy via rapamycin or recombinant HMGB1 potentiated this transition, whereas HMGB1 inhibitor (glycyrrhizin) or autophagy suppressor (spautin-1) markedly attenuated it. Crucially, early postoperative administration of glycyrrhizin or spautin-1 significantly reduced PA severity. Our findings unveil autophagy and HMGB1 as pivotal regulator targets of mesothelial plasticity during PA formation, provide mechanistic insights into peritoneum repair, and propose novel therapeutic avenues for PA prevention.

The brain’s response to intestinal inflammation in Crohn’s disease (CD) remains poorly characterized. We aimed to identify a neuroimaging signature of disease activity by integrating structural and functional brain metrics with machine learning.

Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract. Clinical studies of IBD robustly show elevated interleukin 1β (IL-1β) levels in intestinal tissue, implicating the NLR family pyrin domain containing 3 (NLRP3) inflammasome, which controls IL-1β secretion in myeloid cells. In this study, we aimed to ground potential NLRP3 involvement in IBD in molecular evidence from human studies.

This study aimed to assess the prognostic significance of serum lipoprotein(a) [Lp(a)] levels regarding overall survival (OS) and progression-free survival (PFS) among patients diagnosed with pancreatic cancer (PC).

Cancer treatment is a major concern of health worldwide. Nowadays, colorectal cancer is one of the most prevalent diseases throughout the globe. Therefore, novel cancer treatment modalities are required to stop cancer. Thus, this paper aims to develop a novel drug delivery system (DDS) based on Chitosan (CS), polyamidoamine (PAMAM G4), and Nanoparticles (NP) for efficient delivery of sodium butyrate (NB) and Fe2O3 to SW480 colorectal cancer cells.

This study aimed to investigate the prevalence of gallstone disease among health check-upers (employees) in the Qinghai-Tibet Plateau and clarify the independent effects of altitude, ethnicity, and their interaction on gallstone disease risk, so as to provide evidence for precise prevention and control of gallstone disease in high-altitude multi-ethnic regions.

Assessing quality indicators in colorectal cancer (CRC) screening via the fecal immunochemical test (FIT) is crucial. However, data on developing countries with lower CRC rates, lifestyle transitions, newly established screening programs, and no consensus on optimal targets are scarce.

The safety of morphine in acute pancreatitis (AP) remains controversial due to theoretical risks of exacerbating complications. This study evaluated whether early morphine use correlates with clinical deterioration in AP.

Colorectal cancer (CRC) incidence in Ghana has increased significantly in recent years. Despite medical advances, survival rates remain low, with challenges in CRC screening implementation contributing to late-stage diagnoses and poor outcomes.

Gastrointestinal (GI) motility disorders are characterized by abnormalities in the motor functions of the GI tract. The diagnostic evaluation of these disorders frequently involves invasive and time-consuming examinations, for which access may be limited. Volatile organic compounds (VOCs) could serve as non-invasive alternative. Therefore, the aim of this study was to explore the potential of exhaled breath VOCs as biomarkers in patients with GI symptoms and potential GI motility disorders.

Deep-pelvic Fournier's gangrene (FG) spreading via supralevator abscesses is a rare yet clinically challenging condition, often requiring meticulous surgical intervention to ensure adequate drainage while avoiding critical anatomical injury. Although combined suprapubic and transsacral approaches for extraperitoneal compartment access and linked-loop drainage systems represent innovative strategies, their efficacy and outcomes remain underreported. This study aimed to analyze the clinical outcomes of patients with deep-pelvic Fournier gangrene treated using this dual-approach technique.

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are common tumors of the digestive system. Although their histological diagnosis is usually straightforward, the differential diagnosis between neuroendocrine tumors G3 (NET G3) and neuroendocrine carcinomas (NECs) may be challenging at times due to a similar immunophenotype and morphology in a small number of cases.

The vermiform appendix is prone to various diseases, with acute appendicitis (AA) being the most common. The increasing incidence in Nigeria complicates diagnosis, leading to negative appendectomies. Accurate and timely diagnosis, along with routine histopathological examination, is essential for effective patient care.

The neutrophil to high-density lipoprotein cholesterol ratio (NHR) predicts disease severity in biliary pancreatitis, yet its prognostic role in hypertriglyceridemic acute pancreatitis (HTG-AP) remains unclear.

Autoimmune liver diseases (AILD) are a heterogeneous group of chronic inflammatory conditions characterized by progressive hepatic fibrosis. While liver stiffness measurement (LSM) has emerged as a valuable non-invasive assessment tool, its clinical utility and associated factors in AILD populations remain incompletely characterized, particularly in understudied ethnic populations.

Research exploring the relationship between atrial fibrillation (AF) and acute pancreatitis (AP) is limited. This study aims to explore the association between AF and both the disease severity and in-hospital mortality in AP.