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4161. Serum cholesterol loading capacity of macrophages is regulated by seropositivity and C-reactive protein in rheumatoid arthritis patients.
作者: George A Karpouzas.;Bianca Papotti.;Sarah R Ormseth.;Marcella Palumbo.;Elizabeth Hernandez.;Cinzia Marchi.;Francesca Zimetti.;Matthew J Budoff.;Nicoletta Ronda.
来源: Rheumatology (Oxford). 2023年62卷3期1254-1263页
Excessive cholesterol accumulation in macrophages is the pivotal step underlying atherosclerotic plaque formation. We here explore factors in the serum of patients with RA, and mechanisms through which they interact with and influence cholesterol loading capacity (CLC) of macrophages.
4162. Effective and safe treatment of anti-CD38 therapy in systemic lupus erythematosus-associated refractory cerebral vasculitis induces immune tolerance.
作者: Melek Yalcin Mutlu.;Jochen Wacker.;Koray Tascilar.;Jule Taubmann.;Bernhard Manger.;Gerhard Krönke.;Georg Schett.;David Simon.
来源: Rheumatology (Oxford). 2023年62卷2期e21-e23页 4163. Risankizumab improved health-related quality of life, fatigue, pain and work productivity in psoriatic arthritis: results of KEEPsAKE 1.
作者: Lars Erik Kristensen.;Ahmed M Soliman.;Kim Papp.;Douglas White.;Lisa Barcomb.;Wenjing Lu.;Ann Eldred.;Frank Behrens.
来源: Rheumatology (Oxford). 2023年62卷2期629-637页
PsA is a heterogeneous disease that impacts many aspects of social and mental life, including quality of life. Risankizumab, an antagonist specific for IL-23, is currently under investigation for the treatment of adults with active PsA. This study evaluated the impact of risankizumab vs placebo on health-related quality of life (HRQoL) and other patient-reported outcomes (PROs) among patients with active PsA and inadequate response or intolerance to conventional synthetic DMARD (csDMARD-IR) in the KEEPsAKE 1 trial.
4164. Disease-specific expansion of CD29+IL-17RA+ T effector cells possessing multiple signalling pathways in spondyloarthritis.
作者: Mitsuhiro Akiyama.;Keiko Yoshimoto.;Sho Ishigaki.;Katsuya Suzuki.;Tsutomu Takeuchi.;Yuko Kaneko.
来源: Rheumatology (Oxford). 2023年62卷3期1296-1305页
T cells adhere to enthesis fibrocartilage via integrins and intrinsically require IL-17RA-mediated signals to maintain their effector function. We analysed CD29+IL-17RA+ T cells in inflamed lesions and peripheral blood in patients with SpA and investigated their association with disease activity and therapeutic response.
4165. IL-17A and TNF synergistically drive expression of proinflammatory mediators in synovial fibroblasts via IκBζ-dependent induction of ELF3.
作者: Vesa-Petteri Kouri.;Juri Olkkonen.;Katariina Nurmi.;Nitai Peled.;Mari Ainola.;Jami Mandelin.;Dan C Nordström.;Kari K Eklund.
来源: Rheumatology (Oxford). 2023年62卷2期872-885页
IL-17A and TNF act in synergy to induce proinflammatory mediators in synovial fibroblasts thus contributing to diseases associated with chronic arthritis. Many of these factors are regulated by transcription factor E74-like factor-3 (ELF3). Therefore, we sought to investigate ELF3 as a downstream target of IL-17A and TNF signalling and to characterize its role in the molecular mechanism of synergy between IL-17A and TNF.
4167. Effect of bimekizumab on symptoms and impact of disease in patients with psoriatic arthritis over 3 years: results from BE ACTIVE.
作者: Philip J Mease.;Akihiko Asahina.;Dafna D Gladman.;Yoshiya Tanaka.;William Tillett.;Barbara Ink.;Deepak Assudani.;Christine de la Loge.;Jason Coarse.;Jason Eells.;Laure Gossec.
来源: Rheumatology (Oxford). 2023年62卷2期617-628页
Evaluate effects of long-term bimekizumab treatment on patient-reported outcome (PRO) measures, symptoms and the impact of PsA on patients.
4168. Immunogenicity 6 months post COVID-19 mRNA vaccination among adolescents with juvenile idiopathic arthritis on treatment with TNF inhibitors.
作者: Dimitra Dimopoulou.;Maria N Tsolia.;Nikos Spyridis.;Despoina N Maritsi.
来源: Rheumatology (Oxford). 2023年62卷SI2期SI205-SI209页
Mass vaccination is the most effective strategy for controlling the COVID-19 pandemic. This study aimed to evaluate the 6-month immunogenicity after BNT162b2-COVID-19 vaccination in adolescents with JIA on TNFi treatment.
4169. Long-term cardiovascular outcomes and temporal trends in patients diagnosed with ANCA-associated vasculitis: a Danish nationwide registry study.
作者: Louis Nygaard.;Christoffer Polcwiartek.;Karl Emil Nelveg-Kristensen.;Nicholas Carlson.;Salome Kristensen.;Christian Torp-Pedersen.;Jon Waarst Gregersen.
来源: Rheumatology (Oxford). 2023年62卷2期735-746页
To examine long-term cardiovascular outcomes and temporal trends among patients with ANCA-associated vasculitis (AAV) using Danish nationwide registries.
4170. Anti-CD74 IgA antibodies show diagnostic potential for axial spondyloarthritis but are not associated with microscopic gut inflammation.
作者: Ann-Sophie De Craemer.;Torsten Witte.;Triana Lobaton Ortega.;Anne Hoorens.;Martine De Vos.;Claude Cuvelier.;Sebastiaan J Vastert.;Xenofon Baraliakos.;Filip Van den Bosch.;Dirk Elewaut.
来源: Rheumatology (Oxford). 2023年62卷2期984-990页
Gut inflammation commonly occurs in axial SpA (axSpA), and is linked to disease activity and outcome. Given the role of IgA in mucosal immunity, we explored the association between anti-CD74 IgA antibodies, gut inflammation and axSpA.
4171. Inhibition of calcium/calmodulin-dependent protein kinase IV in arthritis: dual effect on Th17 cell activation and osteoclastogenesis.
作者: Tomohiro Koga.;Masataka Umeda.;Nobuya Yoshida.;Abhigyan Satyam.;Meenakshi Jha.;Marc Scherlinger.;Rhea Bhargava.;Maria G Tsokos.;Tomohito Sato.;Kaori Furukawa.;Yushiro Endo.;Shoichi Fukui.;Naoki Iwamoto.;Norio Abiru.;Minoru Okita.;Masako Ito.;Atsushi Kawakami.;George C Tsokos.
来源: Rheumatology (Oxford). 2023年62卷2期861-871页
To investigate the role of calcium/calmodulin-dependent protein kinase IV (CaMK4) in the development of joint injury in a mouse model of arthritis and patients with RA.
4172. Guselkumab provides sustained domain-specific and comprehensive efficacy using composite indices in patients with active psoriatic arthritis.
作者: Laura C Coates.;Christopher T Ritchlin.;Laure Gossec.;Philip S Helliwell.;Proton Rahman.;Alexa P Kollmeier.;Xie L Xu.;May Shawi.;Chetan S Karyekar.;Christine Contré.;Wim Noël.;Shihong Sheng.;Yanli Wang.;Stephen Xu.;Philip J Mease.
来源: Rheumatology (Oxford). 2023年62卷2期606-616页
To evaluate the efficacy of guselkumab for the treatment of active PsA utilizing composite indices.
4173. Peripheral expansion of myeloid-derived suppressor cells is related to disease activity and damage accrual in inflammatory myopathies.
作者: Jiram Torres-Ruiz.;Abdiel Absalón-Aguilar.;Juan Alberto Reyes-Islas.;Fabiola Cassiano-Quezada.;Nancy R Mejía-Domínguez.;Alfredo Pérez-Fragoso.;José Luis Maravillas-Montero.;Carlos Núñez-Álvarez.;Guillermo Juárez-Vega.;Alejandro Culebro-Bermejo.;Diana Gómez-Martín.
来源: Rheumatology (Oxford). 2023年62卷2期775-784页
To assess the proportion of myeloid-derived suppressor cells (MDSCs), their expression of arginase-1 and programmed cell death ligand 1 (PD-L1) and their relationship with the clinical phenotype of patients with idiopathic inflammatory myopathies (IIMs).
4174. Outcomes of children born to mothers with systemic lupus erythematosus exposed to hydroxychloroquine or azathioprine.
作者: John A Reynolds.;Mary Gayed.;Munther A Khamashta.;Francesca Leone.;Veronica Toescu.;Ian N Bruce.;Ian Giles.;Lee-Suan Teh.;Neil McHugh.;Mohammed Akil.;Christopher J Edwards.;Caroline Gordon.
来源: Rheumatology (Oxford). 2023年62卷3期1124-1135页
HCQ and AZA are used to control disease activity and reduce risk of flare during pregnancy in patients with SLE. The aim of this study was to determine the outcomes of children born to mothers with SLE exposed to HCQ or AZA during pregnancy and breast-feeding.
4175. Genetic contributions to female gout and hyperuricaemia using genome-wide association study and polygenic risk score analyses.
作者: Chien-Yu Lin.;Ya-Sian Chang.;Ting-Yuan Liu.;Chung-Ming Huang.;Chin-Chun Chung.;Yu-Chia Chen.;Fuu-Jen Tsai.;Jan-Gowth Chang.;Shun-Jen Chang.
来源: Rheumatology (Oxford). 2023年62卷2期638-646页
To identify genetic variants and polygenic risk score (PRS) relating to female gout and asymptomatic hyperuricaemia (AH) in a genome-wide association study (GWAS).
4176. Immunosuppressive treatments selectively affect the humoral and cellular response to SARS-CoV-2 in vaccinated patients with vasculitis.
作者: Sara Monti.;Chiara Fornara.;Paolo Delvino.;Alice Bartoletti.;Federica Bergami.;Giuditta Comolli.;Josè Camilla Sammartino.;Alessandro Biglia.;Emanuele Bozzalla Cassione.;Irene Cassaniti.;Fausto Baldanti.;Daniele Lilleri.;Carlomaurizio Montecucco.
来源: Rheumatology (Oxford). 2023年62卷2期726-734页
To analyse humoral and cellular immune response to mRNA COVID-19 vaccines in patients with GCA.
4177. Upregulated expression of FFAR2 and SOC3 genes is associated with gout.
作者: Oliver C Orji.;Maria B López-Domínguez.;Gabriela Sandoval-Plata.;Tamar Guetta-Baranes.;Ana M Valdes.;Michael Doherty.;Kevin Morgan.;Abhishek Abhishek.
来源: Rheumatology (Oxford). 2023年62卷2期977-983页
To examine the expression of Free fatty acid receptor 2 (FFAR2) and Suppressor of cytokine signalling 3 (SOCS3) genes in asymptomatic hyperuricaemia (AH), AH with MSU crystal deposition, inter-critical gout and gout flare.
4178. Late skin fibrosis in systemic sclerosis: a study from the EUSTAR cohort.
作者: Michael Hughes.;Suiyuan Huang.;Juan Jose Alegre-Sancho.;Patricia E Carreira.;Merete Engelhart.;Eric Hachulla.;Joerg Henes.;Eduardo Kerzberg.;Maria Rosa Pozzi.;Gabriela Riemekasten.;Vanessa Smith.;Gabriella Szücs.;Marie Vanthuyne.;Elisabetta Zanatta.;Oliver Distler.;Armando G Gabrielli.;Anna-Maria Hoffmann-Vold.;Virginia D Steen.;Dinesh Khanna.; .
来源: Rheumatology (Oxford). 2023年62卷SI期SI54-SI63页
The early trajectory of skin fibrosis provides insights into the disease course of systemic sclerosis (SSc) including mortality; however, little is known about late skin fibrosis. The aims of our study were to ascertain the prevalence and characteristics of late skin fibrosis in SSc.
4179. Female reproductive status and exogenous sex hormone use in rheumatoid arthritis patients treated with tocilizumab and csDMARDs.
作者: Dala N Daraghmeh.;Ashley M Hopkins.;Catherine King.;Ahmad Y Abuhelwa.;Mihir D Wechalekar.;Susanna M Proudman.;Michael J Sorich.;Michael D Wiese.
来源: Rheumatology (Oxford). 2023年62卷2期583-595页
Sex is well known to influence risk, severity and treatment outcomes of RA, although the underlying causes are uncertain. The aim of this research was to examine whether factors influencing female sex hormones (reproductive status and exogenous sex hormone use) are associated with the efficacy of DMARDs.
4180. Accuracy of power Doppler ultrasonography in the diagnosis and monitoring of idiopathic inflammatory myopathies.
作者: Edoardo Conticini.;Paolo Falsetti.;Silvia Grazzini.;Caterina Baldi.;Roberto D'Alessandro.;Suhel Gabriele Al Khayyat.;Giovanni Biasi.;Francesca Bellisai.;Marco Bardelli.;Stefano Gentileschi.;Estrella Garcia-Gonzalez.;Nila Volpi.;Stefano Barbagli.;Marta Fabbroni.;Miriana d'Alessandro.;Elena Bargagli.;Luca Cantarini.;Bruno Frediani.
来源: Rheumatology (Oxford). 2023年62卷2期766-774页
No clear-cut guidelines exist for the use of imaging procedures for the diagnosis of idiopathic inflammatory myopathies (IIM). The aim of the present study was to assess the diagnostic accuracy of power Doppler ultrasonography (PDUS) score in IIM patients compared with a control group and its usefulness during follow-up.
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