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4141. Systematic review and meta-analysis: the advantage of endoscopic Mayo score 0 over 1 in patients with ulcerative colitis.
作者: Angelo Viscido.;Marco Valvano.;Gianpiero Stefanelli.;Annalisa Capannolo.;Chiara Castellini.;Eugenia Onori.;Antonio Ciccone.;Filippo Vernia.;Giovanni Latella.
来源: BMC Gastroenterol. 2022年22卷1期92页
Mucosal healing (MH) evaluated by endoscopy is a novel target of therapy in UC as it is associated with improved long-term outcomes. It is defined based on the Mayo endoscopic score (MES), but it is still to define whether a value of MES 0 or 1 should be the target. The purpose of this paper is to present the results of a systematic review with meta-analysis which compares long-term outcomes of patients in steroid-free clinical remission with MES 0 with those with MES 1.
4143. Total polyp number may be more important than size and histology of polyps for prediction of metachronous high-risk colorectal neoplasms.
作者: Hyuk Yoon.;Cheol Min Shin.;Young Soo Park.;Nayoung Kim.;Dong Ho Lee.
来源: BMC Gastroenterol. 2022年22卷1期91页
To evaluate whether the risk of metachronous high-risk colorectal neoplasm (HR-CRN) differs according to the indication for surveillance colonoscopy.
4144. Impact of a procalcitonin-based algorithm on the quality of management of patients with uncomplicated adhesion-related small bowel obstruction assessed by a textbook outcome: a multicenter cluster-randomized open-label controlled trial.
作者: Charles Sabbagh.;Francois Mauvais.;Jean-Jacques Tuech.;Christophe Tresallet.;Pablo Ortega-Debalon.;Muriel Mathonnet.;Jeremie H Lefevre.;Zaher Lakkis.;David Fuks.;Fabrice Muscari.;Bernard Dron.;Philippe Couderc.;Arnaud Alves.;Jean-Marc Regimbeau.
来源: BMC Gastroenterol. 2022年22卷1期90页
Acute adhesion-related small bowel obstruction (ASBO) is a common digestive emergency, accounting for 1 to 3% of all digestive emergencies. The efficacy of conservative management in this setting is a subject of debate, as it may delay the decision to perform surgery and increase the frequency of bowel resection (e.g., in the presence of bowel necrosis) or, in contrast, prompt an excessive number of unnecessary laparotomies. Thus, the decision to perform surgery is difficult. We propose that the introduction of the procalcitonin (PCT)-based algorithm improves the quality of the management of patients with ASBO by aiding the decision of whether or not to perform surgery.
4145. Esophageal Motility Disorders: Current Approach to Diagnostics and Therapeutics.
Dysphagia is a common symptom with significant impact on quality of life. Our diagnostic armamentarium was primarily limited to endoscopy and barium esophagram until the advent of manometric techniques in the 1970s, which provided the first reliable tool for assessment of esophageal motor function. Since that time, significant advances have been made over the last 3 decades in our understanding of various esophageal motility disorders due to improvement in diagnostics with high-resolution esophageal manometry. High-resolution esophageal manometry has improved the sensitivity for detecting achalasia and has also enhanced our understanding of spastic and hypomotility disorders of the esophageal body. In this review, we discuss the current approach to diagnosis and therapeutics of various esophageal motility disorders.
4146. Transitional Anal Cells Mediate Colonic Re-epithelialization in Colitis.
作者: Cambrian Y Liu.;Nandini Girish.;Marie L Gomez.;Philip E Dubé.;M Kay Washington.;Benjamin D Simons.;D Brent Polk.
来源: Gastroenterology. 2022年162卷7期1975-1989页
Epithelial wound healing is compromised and represents an unleveraged therapeutic target in inflammatory bowel disease (IBD). Intestinal epithelial cells exhibit plasticity that facilitates dedifferentiation and repair during the response to injury. However, it is not known whether epithelial cells of a neighboring organ can be activated to mediate re-epithelialization in acute colitis. Histological findings of a permanent squamous tissue structure in the distal colon in human IBD could suggest diverse cellular origins of repair-associated epithelium. Here, we tested whether skin-like cells from the anus mediate colonic re-epithelialization in murine colitis.
4147. Higher vs Standard Adalimumab Induction and Maintenance Dosing Regimens for Treatment of Ulcerative Colitis: SERENE UC Trial Results.
作者: Julián Panés.;Jean-Frederic Colombel.;Geert R D'Haens.;Stefan Schreiber.;Remo Panaccione.;Laurent Peyrin-Biroulet.;Edward V Loftus.;Silvio Danese.;Satoshi Tanida.;Yusuke Okuyama.;Edouard Louis.;Alessandro Armuzzi.;Marc Ferrante.;Harald Vogelsang.;Toshifumi Hibi.;Mamoru Watanabe.;Jessica Lefebvre.;Tricia Finney-Hayward.;Yuri Sanchez Gonzalez.;Thao T Doan.;Nael M Mostafa.;Kimitoshi Ikeda.;Wangang Xie.;Bidan Huang.;Joel Petersson.;Jasmina Kalabic.;Anne M Robinson.;William J Sandborn.
来源: Gastroenterology. 2022年162卷7期1891-1910页
SERENE UC (Study of a Novel Approach to Induction and Maintenance Dosing With Adalimumab in Patients With Moderate to Severe Ulcerative Colitis) evaluated the efficacy of higher adalimumab induction and maintenance dose regimens in patients with ulcerative colitis.
4148. Correction to: How to manage celiac disease and gluten-free diet during the COVID-19 era: proposals from a tertiary referral center in a high-incidence scenario.
作者: Luca Elli.;Donatella Barisani.;Valentina Vaira.;Maria Teresa Bardella.;Matilde Topa.;Maurizio Vecchi.;Luisa Doneda.;Alice Scricciolo.;Vincenza Lombardo.;Leda Roncoroni.
来源: BMC Gastroenterol. 2022年22卷1期86页 4149. Recent advances in the diagnosis of intestinal tuberculosis.
作者: Hasan Maulahela.;Marcellus Simadibrata.;Erni Juwita Nelwan.;Nur Rahadiani.;Editha Renesteen.;S W T Suwarti.;Yunita Windi Anggraini.
来源: BMC Gastroenterol. 2022年22卷1期89页
Intestinal tuberculosis still has a high incidence, especially in developing countries. The biggest challenge of this disease is the establishment of the diagnosis because the clinical features are not typical. Investigations such as culture, acid-fast bacilli (AFB) staining, and histopathology have low sensitivity, so other investigations are needed. Latest molecular-based diagnostic modalities such as GeneXpert, interferon-gamma (IFN-γ) release assays (IGRA), polymerase chain reaction (PCR), multiplex-PCR, and immunological markers are expected to help diagnose intestinal tuberculosis. This article review will examine the latest diagnostic modalities that can be used as a tool in establishing the diagnosis of intestinal tuberculosis.
4150. The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal cancer.
作者: Ruixue Lei.;Yanteng Zhao.;Kai Huang.;Qian Wang.;Kangkang Wan.;Tingting Li.;Haijun Yang.;Xianping Lv.
来源: BMC Gastroenterol. 2022年22卷1期88页
Methylated SDC2 and TFPI2 are widely used for colorectal cancer (CRC) detection. However, they often miss some CRCs, which directly diminishes the sensitivity. Further investigations of the underlying mechanisms leading to the missed samples will facilitate developing more eligible methylation markers.
4151. Methylated septin 9 gene is an important prognostic marker in stage II and stage III colorectal cancer for evaluating local recurrence or distant metastasis after surgery.
作者: Mingliang Huang.;Jiehua He.;Wei Lai.;Lu Liu.;Heyang Xu.;Yujie Zeng.;Qiusheng Lan.;Xiangan Lin.;Zhonghua Chu.
来源: BMC Gastroenterol. 2022年22卷1期87页
Abnormal hypermethylation of the septin 9 gene was an inchoate incident in some cancers. Though latest several researches had paid attention to its value in prognosis, the consequences were not distinctly, especially in colorectal cancer (CRC) with stage II and stage III.
4152. Fecal indicator bacteria along multiple environmental exposure pathways (water, food, and soil) and intestinal parasites among children in the rural northwest Ethiopia.
作者: Zemichael Gizaw.;Alemayehu Worku Yalew.;Bikes Destaw Bitew.;Jiyoung Lee.;Michael Bisesi.
来源: BMC Gastroenterol. 2022年22卷1期84页
Children in low-resource settings are exposed to multiple risk factors for enteropathogens. However, the probability of exposures may be different across exposure pathways. Accordingly, this study was conducted to assess environmental exposures of children to intestinal parasites in the east Dembiya district of Ethiopia.
4153. Machine learning-based survival rate prediction of Korean hepatocellular carcinoma patients using multi-center data.
作者: Byeonggwan Noh.;Young Mok Park.;Yujin Kwon.;Chang In Choi.;Byung Kwan Choi.;Kwang Il Seo.;Yo-Han Park.;Kwangho Yang.;Sunju Lee.;Taeyoung Ha.;YunKyong Hyon.;Myunghee Yoon.
来源: BMC Gastroenterol. 2022年22卷1期85页
To predict survival time of Korean hepatocellular carcinoma (HCC) patients using multi-center data as a foundation for the development of a predictive artificial intelligence model according to treatment methods based on machine learning.
4154. Efficacy of sigmoidoscopy for evaluating disease activity in patients with ulcerative colitis.
作者: Su Bum Park.;Seong-Jung Kim.;Jun Lee.;Yoo Jin Lee.;Dong Hoon Baek.;Geom Seog Seo.;Eun Soo Kim.;Sang-Wook Kim.;So Yeong Kim.
来源: BMC Gastroenterol. 2022年22卷1期83页
Endoscopic assessment of disease activity is a key parameter in the management of ulcerative colitis. Whether sigmoidoscopy alone is sufficient to evaluate the disease activity in ulcerative colitis lacks studies.
4155. Mucin 5AC-Mediated CD44/ITGB1 Clustering Mobilizes Adipose-Derived Mesenchymal Stem Cells to Modulate Pancreatic Cancer Stromal Heterogeneity.
作者: Koelina Ganguly.;Jesse L Cox.;Dario Ghersi.;Paul M Grandgenett.;Michael A Hollingsworth.;Maneesh Jain.;Sushil Kumar.;Surinder K Batra.
来源: Gastroenterology. 2022年162卷7期2032-2046.e12页
Secreted mucin 5AC (MUC5AC) promotes pancreatic cancer (PC) progression and chemoresistance, suggesting its clinical association with poor prognosis. RNA sequencing analysis from the autochthonous pancreatic tumors showed a significant stromal alteration on genetic ablation of Muc5ac. Previously, depletion or targeting the stromal fibroblasts showed an ambiguous effect on PC pathogenesis. Hence, identifying the molecular players and mechanisms driving fibroblast heterogeneity is critical for improved clinical outcomes.
4157. Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment.
作者: Carolina J Garcia Garcia.;Yanqing Huang.;Natividad R Fuentes.;Madeleine C Turner.;Maria E Monberg.;Daniel Lin.;Nicholas D Nguyen.;Tara N Fujimoto.;Jun Zhao.;Jaewon J Lee.;Vincent Bernard.;Meifang Yu.;Abagail M Delahoussaye.;Iancarlos Jimenez Sacarello.;Emily G Caggiano.;Jae L Phan.;Amit Deorukhkar.;Jessica M Molkentine.;Dieter Saur.;Anirban Maitra.;Cullen M Taniguchi.
来源: Gastroenterology. 2022年162卷7期2018-2031页
Pancreatic ductal adenocarcinoma (PDAC) has a hypoxic, immunosuppressive stroma that contributes to its resistance to immune checkpoint blockade therapies. The hypoxia-inducible factors (HIFs) mediate the cellular response to hypoxia, but their role within the PDAC tumor microenvironment remains unknown.
4158. Protocol for a randomized controlled multicenter trial assessing the efficacy of leuprorelin for severe polycystic liver disease: the AGAINST-PLD study.
作者: S E Aapkes.;L H P Bernts.;A P van den Berg.;M van den Berg.;H Blokzijl.;A E P Cantineau.;M D A van Gastel.;R J de Haas.;P Kappert.;R U Müller.;F Nevens.;R Torra.;A Visser.;J P H Drenth.;R T Gansevoort.
来源: BMC Gastroenterol. 2022年22卷1期82页
In patients with severe polycystic liver disease (PLD), there is a need for new treatments. Estrogens and possibly other female sex hormones stimulate growth in PLD. In some patients, liver volume decreases after menopause. Female sex hormones could therefore be a target for therapy. The AGAINST-PLD study will examine the efficacy of the GnRH agonist leuprorelin, which blocks the production of estrogen and other sex hormones, to reduce liver growth in PLD.
4160. AGA Clinical Practice Guideline on Systemic Therapy for Hepatocellular Carcinoma.
作者: Grace L Su.;Osama Altayar.;Robert O'Shea.;Raj Shah.;Bassam Estfan.;Candice Wenzell.;Shahnaz Sultan.;Yngve Falck-Ytter.
来源: Gastroenterology. 2022年162卷3期920-934页
Hepatocellular carcinoma (HCC), the most common primary liver cancer, remains a deadly cancer, with an incidence that has tripled in the United States since 1980. In recent years, new systemic therapies for HCC have been approved and a critical assessment of the existing data is necessary to balance benefits and harms and inform the development of evidence-based guidelines.
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