4148. Unexplained Female Infertility Associated with Genetic Disease Variants.
作者: Michael P Dougherty.;Alexandra M Poch.;Lynn P Chorich.;Zoe A Hawkins.;Hongyan Xu.;Robert A Roman.;Haitao Liu.;Soumia Brakta.;Hugh S Taylor.;James Knight.;Hyung-Goo Kim.;Michael P Diamond.;Lawrence C Layman.
来源: N Engl J Med. 2023年388卷11期1055-1056页 4157. Trial of Hybrid Closed-Loop Control in Young Children with Type 1 Diabetes.
作者: R Paul Wadwa.;Zachariah W Reed.;Bruce A Buckingham.;Mark D DeBoer.;Laya Ekhlaspour.;Gregory P Forlenza.;Melissa Schoelwer.;John Lum.;Craig Kollman.;Roy W Beck.;Marc D Breton.; .
来源: N Engl J Med. 2023年388卷11期991-1001页
Closed-loop control systems of insulin delivery may improve glycemic outcomes in young children with type 1 diabetes. The efficacy and safety of initiating a closed-loop system virtually are unclear.
4158. Inaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants.
作者: Ogo Egbuna.;Brandon Zimmerman.;George Manos.;Anne Fortier.;Madalina C Chirieac.;Leslie A Dakin.;David J Friedman.;Kate Bramham.;Kirk Campbell.;Bertrand Knebelmann.;Laura Barisoni.;Ronald J Falk.;Debbie S Gipson.;Michael S Lipkowitz.;Akinlolu Ojo.;Mark E Bunnage.;Martin R Pollak.;David Altshuler.;Glenn M Chertow.; .
来源: N Engl J Med. 2023年388卷11期969-979页
Persons with toxic gain-of-function variants in the gene encoding apolipoprotein L1 (APOL1) are at greater risk for the development of rapidly progressive, proteinuric nephropathy. Despite the known genetic cause, therapies targeting proteinuric kidney disease in persons with two APOL1 variants (G1 or G2) are lacking.
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