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4061. Real world evidence of the association between medication and life expectancy in elderly inflammatory bowel disease: a population-based cohort study.
作者: M Ellen Kuenzig.;Douglas G Manuel.;Jessy Donelle.;Eric I Benchimol.
来源: BMC Gastroenterol. 2022年22卷1期5页
Life expectancy in people with inflammatory bowel disease (IBD) has increased but remains shorter than in people without IBD. We describe the life expectancy associated with IBD therapies among the growing number of older adults living with IBD.
4062. Trend of geographical distribution of stomach cancer in Iran from 2004 to 2014.
作者: Farid Moradian.;Mohammad Fararouei.;Maryam Karami.;Mousa Ghelichi-Ghojogh.;Zahra Gheibi.;Zahra Nikeghbalian.;Atieh Akbari.;Mohammad-Esmaeil Akbari.
来源: BMC Gastroenterol. 2022年22卷1期4页
Among different common types of cancer, gastric cancer (GC) is a worldwide health priority in both developing and developed countries. The aim of this study was to map the distribution of incident cases of GC in Iran to provide a geographical presentation of the incidence of the disease.
4063. A large undifferentiated sarcoma of the liver in a 13-year-old girl treated with anatomical resection: a case report and review of the literature.
作者: Ali Bahador.;Mehdi Forooghi.;Reza Shahriarirad.;Bita Geramizadeh.;Maryam Ataollahi.;Hooman Kamran.
来源: BMC Gastroenterol. 2022年22卷1期2页
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare liver tumor accounting for 6-13% of primary liver tumors. Accurate preoperative diagnosis is difficult, with a rather high misdiagnosis rate. Herein, we reported a very large UESL treated with anatomical resection. Our case is amongst the largest pediatric UESLs in the literature.
4064. Phosphoserine phosphatase as a prognostic biomarker in patients with gastric cancer and its potential association with immune cells.
作者: Ma-Yan Huang.;Xiao-Yun Liu.;Qiong Shao.;Xu Zhang.;Lei Miao.;Xiao-Yan Wu.;Yu-Xia Xu.;Fang Wang.;Hai-Yun Wang.;Liang Zeng.;Ling Deng.
来源: BMC Gastroenterol. 2022年22卷1期1页
Because of dismal prognosis in gastric cancer, identifying relevant prognostic factors is necessary. Phosphoserine phosphatase (PSPH) exhibits different expression patterns in many cancers and has been reported to affect the prognosis of patients with cancer. In this study, we examined the prognostic role of metabolic gene PSPH in gastric cancer based on the TCGA dataset and our hospital-based cohort cases.
4065. The association of zonulin-related proteins with prevalent and incident inflammatory bowel disease.
作者: Xiao Wang.;Ashfaque A Memon.;Karolina Palmér.;Anna Hedelius.;Jan Sundquist.;Kristina Sundquist.
来源: BMC Gastroenterol. 2022年22卷1期3页
Current evidence regarding the association of serum zonulin-related proteins (ZRP) levels with prevalent inflammatory bowel disease (IBD) is contradictory. Moreover, the association with the subsequent risk of incident IBD is still unexplored. This study aimed to investigate the association of serum ZRP levels with both prevalent and incident IBD.
4067. Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus.
作者: James A Evans.;Emanuela Carlotti.;Meng-Lay Lin.;Richard J Hackett.;Magnus J Haughey.;Adam M Passman.;Lorna Dunn.;George Elia.;Ross J Porter.;Mairi H McLean.;Frances Hughes.;Joanne ChinAleong.;Philip Woodland.;Sean L Preston.;S Michael Griffin.;Laurence Lovat.;Manuel Rodriguez-Justo.;Weini Huang.;Nicholas A Wright.;Marnix Jansen.;Stuart A C McDonald.
来源: Gastroenterology. 2022年162卷4期1197-1209.e13页
Barrett's esophagus (BE) is a risk factor for esophageal adenocarcinoma but our understanding of how it evolves is poorly understood. We investigated BE gland phenotype distribution, the clonal nature of phenotypic change, and how phenotypic diversity plays a role in progression.
4068. Intestinal Cathelicidin Antimicrobial Peptide Shapes a Protective Neonatal Gut Microbiota Against Pancreatic Autoimmunity.
作者: Wenjie Liang.;Emmanuelle Enée.;Cédric Andre-Vallee.;Marika Falcone.;Jia Sun.;Julien Diana.
来源: Gastroenterology. 2022年162卷4期1288-1302.e16页
Alteration of the gut microbiota is implicated in the development of autoimmune type 1 diabetes (T1D), as shown in humans and the nonobese diabetic (NOD) mouse model. However, how gut dysbiosis arises and promotes the autoimmune response remains an open question. We investigated whether early events affecting the intestinal homeostasis in newborn NOD mice may explain the development of the autoimmune response in the adult pancreas.
4069. Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma.
作者: Abdel Nasser Hosein.;Gita Dangol.;Takashi Okumura.;Jason Roszik.;Kimal Rajapakshe.;Megan Siemann.;Mohamed Zaid.;Bidyut Ghosh.;Maria Monberg.;Paola A Guerrero.;Aatur Singhi.;Cara L Haymaker.;Hans Clevers.;Lotfi Abou-Elkacem.;Sonja M Woermann.;Anirban Maitra.
来源: Gastroenterology. 2022年162卷4期1303-1318.e18页
RNF43 is an E3 ubiquitin ligase that is recurrently mutated in pancreatic ductal adenocarcinoma (PDAC) and precursor cystic neoplasms of the pancreas. The impact of RNF43 mutations on PDAC is poorly understood and autochthonous models have not been characterized sufficiently. In this study, we describe a genetically engineered mouse model (GEMM) of PDAC with conditional expression of oncogenic Kras and deletion of the catalytic domain of Rnf43 in exocrine cells.
4070. N6-Methyladenosine Reader YTHDF1 Promotes ARHGEF2 Translation and RhoA Signaling in Colorectal Cancer.
作者: Shiyan Wang.;Shanshan Gao.;Yong Zeng.;Lin Zhu.;Yulin Mo.;Chi Chun Wong.;Yi Bao.;Peiran Su.;Jianning Zhai.;Lina Wang.;Fraser Soares.;Xin Xu.;Huarong Chen.;Kebria Hezaveh.;Xinpei Ci.;Aobo He.;Tracy McGaha.;Catherine O'Brien.;Robert Rottapel.;Wei Kang.;Jianfeng Wu.;Gang Zheng.;Zongwei Cai.;Jun Yu.;Housheng Hansen He.
来源: Gastroenterology. 2022年162卷4期1183-1196页
N6-methyladenosine (m6A) governs the fate of RNAs through m6A readers. Colorectal cancer (CRC) exhibits aberrant m6A modifications and expression of m6A regulators. However, how m6A readers interpret oncogenic m6A methylome to promote malignant transformation remains to be illustrated.
4073. Clinical and Endoscopic Characteristics Associated With Post-Endoscopy Upper Gastrointestinal Cancers: A Systematic Review and Meta-analysis.
作者: Leo Alexandre.;Theo Tsilegeridis-Legeris.;Stephen Lam.
来源: Gastroenterology. 2022年162卷4期1123-1135页
Ten percent of patients with an upper gastrointestinal cancer will have received an esophagogastroduodenoscopy (EGD) within 3 years before diagnosis, termed post-endoscopy upper gastrointestinal cancers (PEUGIC). We aimed to determine the characteristics of PEUGIC, and compare these with detected cancers.
4077. Inhibition of p53 Sulfoconjugation Prevents Oxidative Hepatotoxicity and Acute Liver Failure.
作者: Pengfei Xu.;Yue Xi.;Pengcheng Wang.;Zigmund Luka.;Meishu Xu.;Hung-Chun Tung.;Jingyuan Wang.;Songrong Ren.;Dechun Feng.;Bin Gao.;Aatur D Singhi.;Satdarshan P Monga.;John D York.;Xiaochao Ma.;Zhiying Huang.;Wen Xie.
来源: Gastroenterology. 2022年162卷4期1226-1241页
Sulfoconjugation of small molecules or protein peptides is a key mechanism to ensure biochemical and functional homeostasis in mammals. The PAPS synthase 2 (PAPSS2) is the primary enzyme to synthesize the universal sulfonate donor 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Acetaminophen (APAP) overdose is the leading cause of acute liver failure (ALF), in which oxidative stress is a key pathogenic event, whereas sulfation of APAP contributes to its detoxification. The goal of this study was to determine whether and how PAPSS2 plays a role in APAP-induced ALF.
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