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4053. CagA-specific Gastric CD8+ Tissue-Resident T Cells Control Helicobacter pylori During the Early Infection Phase.
作者: Maximilian R A Koch.;Ruolan Gong.;Verena Friedrich.;Veronika Engelsberger.;Lorenz Kretschmer.;Andreas Wanisch.;Sebastian Jarosch.;Anna Ralser.;Bob Lugen.;Michael Quante.;Michael Vieth.;Riccardo Vasapolli.;Christian Schulz.;Veit R Buchholz.;Dirk H Busch.;Raquel Mejías-Luque.;Markus Gerhard.
来源: Gastroenterology. 2023年164卷4期550-566页
Infection with Helicobacter pylori strongly affects global health by causing chronic gastritis, ulcer disease, and gastric cancer. Although extensive research into the strong immune response against this persistently colonizing bacterium exists, the specific role of CD8+ T cells remains elusive.
4054. Constitutional Microsatellite Instability, Genotype, and Phenotype Correlations in Constitutional Mismatch Repair Deficiency.
作者: Richard Gallon.;Rachel Phelps.;Christine Hayes.;Laurence Brugieres.;Léa Guerrini-Rousseau.;Chrystelle Colas.;Martine Muleris.;Neil A J Ryan.;D Gareth Evans.;Hannah Grice.;Emily Jessop.;Annabel Kunzemann-Martinez.;Lilla Marshall.;Esther Schamschula.;Klaus Oberhuber.;Amedeo A Azizi.;Hagit Baris Feldman.;Andreas Beilken.;Nina Brauer.;Triantafyllia Brozou.;Karin Dahan.;Ugur Demirsoy.;Benoît Florkin.;William Foulkes.;Danuta Januszkiewicz-Lewandowska.;Kristi J Jones.;Christian P Kratz.;Stephan Lobitz.;Julia Meade.;Michaela Nathrath.;Hans-Jürgen Pander.;Claudia Perne.;Iman Ragab.;Tim Ripperger.;Thorsten Rosenbaum.;Daniel Rueda.;Tomasz Sarosiek.;Astrid Sehested.;Isabel Spier.;Manon Suerink.;Stefanie-Yvonne Zimmermann.;Johannes Zschocke.;Gillian M Borthwick.;Katharina Wimmer.;John Burn.;Michael S Jackson.;Mauro Santibanez-Koref.
来源: Gastroenterology. 2023年164卷4期579-592.e8页
Constitutional mismatch repair deficiency (CMMRD) is a rare recessive childhood cancer predisposition syndrome caused by germline mismatch repair variants. Constitutional microsatellite instability (cMSI) is a CMMRD diagnostic hallmark and may associate with cancer risk. We quantified cMSI in a large CMMRD patient cohort to explore genotype-phenotype correlations using novel MSI markers selected for instability in blood.
4055. Efficacy and Safety of Drugs for Gastroparesis: Systematic Review and Network Meta-analysis.
作者: Maria Rosa Ingrosso.;Michael Camilleri.;Jan Tack.;Gianluca Ianiro.;Christopher J Black.;Alexander C Ford.
来源: Gastroenterology. 2023年164卷4期642-654页
Although there have been multiple drugs tested in gastroparesis, their relative efficacy and safety are unknown. We evaluated this in a network meta-analysis of randomized controlled trials (RCTs).
4056. High Discovery Rate of Duodenal and Gastric Eosinophilia in Patients With Unexplained Moderate-Severe Abdominal Symptoms: A Prospective US Multisite Study.
作者: Nicholas J Talley.;Kathryn A Peterson.;Robert M Genta.;Alan T Chang.;Evan S Dellon.;William J Sandborn.; .;Brian E Lacy.;Mirna Chehade.;Ikuo Hirano.;Nirmala Gonsalves.;Anthony Lembo.;Colleen M Schmitt.;Marc E Rothenberg.;Neal Jain.;Maria A Pletneva.;Kevin O Turner.;Bradford A Youngblood.
来源: Gastroenterology. 2023年164卷4期680-683.e2页 4057. Integrated Multi-Omics Landscape of Liver Metastases.
作者: Shuai Yang.;Ling Qian.;Zhixuan Li.;Ye Li.;Jian Bai.;Bo Zheng.;Kun Chen.;Xinyao Qiu.;Guoxiang Cai.;Shan Wang.;Haiyan Huang.;Jianmin Wu.;Yanjing Zhu.;Qianwen Zhangyang.;Lanyun Feng.;Tong Wu.;Rui Wu.;Airong Yang.;Kaiting Wang.;Ruiru Wang.;Yani Zhang.;Yan Zhao.;Wenwen Wang.;Jinxia Bao.;Siyun Shen.;Ji Hu.;Xuan Wu.;Tao Zhou.;Zhiqiang Meng.;Weiwei Liu.;Hongyang Wang.;Peng Wang.;Lei Chen.
来源: Gastroenterology. 2023年164卷3期407-423.e17页
Lack of thorough knowledge about the complicated immune microenvironment (IM) within a variety of liver metastases (LMs) leads to inappropriate treatment and unsatisfactory prognosis. We aimed to characterize IM subtypes and investigate potential mechanisms in LMs.
4058. Negative Impact of Disorders of Gut-Brain Interaction on Health-Related Quality of Life: Results From the Rome Foundation Global Epidemiology Survey.
作者: Simon R Knowles.;David Skvarc.;Alexander C Ford.;Olafur S Palsson.;Shrikant I Bangdiwala.;Ami D Sperber.;Antonina Mikocka-Walus.
来源: Gastroenterology. 2023年164卷4期655-668.e10页
This study used the database from the Rome Foundation Global Epidemiology Survey to assess the differences in quality of life overall, and by age and sex, across individual disorders of gut-brain interaction (DGBI), gastrointestinal anatomical region(s), and number of overlapping DGBI.
4060. Intestinal Permeability Improvement With Nutritional Therapy Is Associated With Specific Microbiome Profiles and Functional Pathways in Pediatric Crohn's Disease.
作者: Charlotte M Verburgt.;Rotem Sigall Boneh.;Katherine Dunn.
来源: Gastroenterology. 2023年164卷6期1025-1026页 |