4050. Effect of Donor Sex on Recipient Mortality in Transfusion.
作者: Michaël Chassé.;Dean A Fergusson.;Alan Tinmouth.;Jason P Acker.;Iris Perelman.;Angie Tuttle.;Shane W English.;Steven Hawken.;Alan J Forster.;Nadine Shehata.;Kednapa Thavorn.;Kumanan Wilson.;Nancy Cober.;Heather Maddison.;Melanie Tokessy.
来源: N Engl J Med. 2023年388卷15期1386-1395页
Conflicting observational evidence exists regarding the association between the sex of red-cell donors and mortality among transfusion recipients. Evidence to inform transfusion practice and policy is limited.
4051. Dersimelagon in Erythropoietic Protoporphyrias.
作者: Manisha Balwani.;Herbert L Bonkovsky.;Cynthia Levy.;Karl E Anderson.;D Montgomery Bissell.;Charles Parker.;Fumihiro Takahashi.;Robert J Desnick.;Kirstine Belongie.; .
来源: N Engl J Med. 2023年388卷15期1376-1385页
Erythropoietic protoporphyria and X-linked protoporphyria are inborn errors of heme biosynthesis that cause elevated circulating levels of metal-free protoporphyrin and phototoxicity. Both disorders are characterized by excruciating phototoxic attacks after exposure to visible light. Dersimelagon is a new, orally administered, selective melanocortin 1 receptor agonist that increases levels of skin eumelanin.
4052. Tranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery.
作者: Luis D Pacheco.;Rebecca G Clifton.;George R Saade.;Steven J Weiner.;Samuel Parry.;John M Thorp.;Monica Longo.;Ashley Salazar.;Wendy Dalton.;Alan T N Tita.;Cynthia Gyamfi-Bannerman.;Suneet P Chauhan.;Torri D Metz.;Kara Rood.;Dwight J Rouse.;Jennifer L Bailit.;William A Grobman.;Hyagriv N Simhan.;George A Macones.; .
来源: N Engl J Med. 2023年388卷15期1365-1375页
Prophylactic use of tranexamic acid at the time of cesarean delivery has been shown to decrease the calculated blood loss, but the effect on the need for blood transfusions is unclear.
4056. Genomic Diagnosis of Rare Pediatric Disease in the United Kingdom and Ireland.
作者: Caroline F Wright.;Patrick Campbell.;Ruth Y Eberhardt.;Stuart Aitken.;Daniel Perrett.;Simon Brent.;Petr Danecek.;Eugene J Gardner.;V Kartik Chundru.;Sarah J Lindsay.;Katrina Andrews.;Juliet Hampstead.;Joanna Kaplanis.;Kaitlin E Samocha.;Anna Middleton.;Julia Foreman.;Rachel J Hobson.;Michael J Parker.;Hilary C Martin.;David R FitzPatrick.;Matthew E Hurles.;Helen V Firth.; .
来源: N Engl J Med. 2023年388卷17期1559-1571页
Pediatric disorders include a range of highly penetrant, genetically heterogeneous conditions amenable to genomewide diagnostic approaches. Finding a molecular diagnosis is challenging but can have profound lifelong benefits.
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