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4011. Indigenous determinants of health: a unified call for progress.
作者: Nicole Redvers.;Papaarangi Reid.;Danya Carroll.;Myrna Cunningham Kain.;Daniel M Kobei.;Kelly Menzel.;Donald K Warne.;Allison Kelliher.;Geoffrey Roth.
来源: Lancet. 2023年402卷10395期7-9页 4012. High-dose dual-antibiotic loaded cement for hip hemiarthroplasty in the UK (WHiTE 8): a randomised controlled trial.
作者: Nickil R Agni.;Matthew L Costa.;Juul Achten.;Nicholas Peckham.;Susan J Dutton.;May Ee Png.;Mike R Reed.; .
来源: Lancet. 2023年402卷10397期196-202页
Hip fracture is the most common injury requiring treatment in hospital. Controversy exists regarding the use of antibiotic loaded bone cement in hip fractures treated with hemiarthroplasty. We aimed to compare the rate of deep surgical site infection in patients receiving high-dose dual-antibiotic loaded cement versus standard care single-antibiotic loaded cement.
4014. Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment Consortium.
作者: Monica S Thakar.;Brent R Logan.;Jennifer M Puck.;Elizabeth A Dunn.;Rebecca H Buckley.;Morton J Cowan.;Richard J O'Reilly.;Neena Kapoor.;Lisa Forbes Satter.;Sung-Yun Pai.;Jennifer Heimall.;Sharat Chandra.;Christen L Ebens.;Deepak Chellapandian.;Olatundun Williams.;Lauri M Burroughs.;Blachy Davila Saldana.;Ahmad Rayes.;Lisa M Madden.;Shanmuganathan Chandrakasan.;Jeffrey J Bednarski.;Kenneth B DeSantes.;Geoffrey D E Cuvelier.;Pierre Teira.;Alfred P Gillio.;Hesham Eissa.;Alan P Knutsen.;Frederick D Goldman.;Victor M Aquino.;Evan B Shereck.;Theodore B Moore.;Emi H Caywood.;Mark T Vander Lugt.;Jacob Rozmus.;Larisa Broglie.;Lolie C Yu.;Ami J Shah.;Jeffrey R Andolina.;Xuerong Liu.;Roberta E Parrott.;Jasmeen Dara.;Susan Prockop.;Caridad A Martinez.;Malika Kapadia.;Soma C Jyonouchi.;Kathleen E Sullivan.;Jack J Bleesing.;Sonali Chaudhury.;Aleksandra Petrovic.;Michael D Keller.;Troy C Quigg.;Suhag Parikh.;Shalini Shenoy.;Christine Seroogy.;Tamar Rubin.;Hélène Decaluwe.;John M Routes.;Troy R Torgerson.;Jennifer W Leiding.;Michael A Pulsipher.;Donald B Kohn.;Linda M Griffith.;Elie Haddad.;Christopher C Dvorak.;Luigi D Notarangelo.
来源: Lancet. 2023年402卷10396期129-140页
Severe combined immunodeficiency (SCID) is fatal unless durable adaptive immunity is established, most commonly through allogeneic haematopoietic cell transplantation (HCT). The Primary Immune Deficiency Treatment Consortium (PIDTC) explored factors affecting the survival of individuals with SCID over almost four decades, focusing on the effects of population-based newborn screening for SCID that was initiated in 2008 and expanded during 2010-18.
4016. Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London.
作者: Chris Bailey.;Theo Sanderson.;Hermaleigh Townsley.;Jacki Goldman.;James R M Black.;George Young.;Robert Goldstone.;Ashley S Fowler.;Sophia Ward.;Deborah J Jackson.;Laura Cubitt.;Vicky Dearing.;Olga O'Neil.;Marg Crawford.;Daniel Snell.;Makis Finadis.;Amelia Edwards.;Jimena Perez-Lloret.;Joshua Gahir.;Edward J Carr.;Andy Riddell.;Jim Aitken.;Karen Ambrose.;Chelsea Sawyer.;Nicola O'Reilly.;Simon Caidan.;Mary Y Wu.;Philip A Walker.;Steve Hindmarsh.;Michael Howell.;Andrew Jordan.;James Fleming.;Catherine Houlihan.;Eleni Nastouli.;Rachel Moores.;Desmond Hsu.;Padmasayee Papineni.;Tumena Corrah.;Richard Gilson.;James MacRae.;Michael Hubank.;Nicholas Van As.;Samra Turajlic.;Rupert Beale.;Marcel Levi.; .;Sam Barrell.;Bryan Williams.;Steve Gamblin.;Jerome Nicod.;Sonia Gandhi.;David L V Bauer.;Emma C Wall.;Charles Swanton.
来源: Lancet. 2023年402卷10395期21-24页 4018. Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial.
作者: Michael G Collins.;Magid A Fahim.;Elaine M Pascoe.;Carmel M Hawley.;David W Johnson.;Julie Varghese.;Laura E Hickey.;Philip A Clayton.;Kathryn B Dansie.;Rachael C McConnochie.;Liza A Vergara.;Charani Kiriwandeniya.;Donna Reidlinger.;Peter F Mount.;Laurence Weinberg.;Colin J McArthur.;P Toby Coates.;Zoltan H Endre.;David Goodman.;Kirsten Howard.;Martin Howell.;Jagadish S Jamboti.;John Kanellis.;Jerome M Laurence.;Wai H Lim.;Steven J McTaggart.;Philip J O'Connell.;Helen L Pilmore.;Germaine Wong.;Steven J Chadban.; .; .
来源: Lancet. 2023年402卷10396期105-117页
Delayed graft function (DGF) is a major adverse complication of deceased donor kidney transplantation. Intravenous fluids are routinely given to patients receiving a transplant to maintain intravascular volume and optimise graft function. Saline (0·9% sodium chloride) is widely used but might increase the risk of DGF due to its high chloride content. We aimed to test our hypothesis that using a balanced low-chloride crystalloid solution (Plasma-Lyte 148) instead of saline would reduce the incidence of DGF.
4020. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study.
作者: Arvind Dasari.;Sara Lonardi.;Rocio Garcia-Carbonero.;Elena Elez.;Takayuki Yoshino.;Alberto Sobrero.;James Yao.;Pilar García-Alfonso.;Judit Kocsis.;Antonio Cubillo Gracian.;Andrea Sartore-Bianchi.;Taroh Satoh.;Violaine Randrian.;Jiri Tomasek.;Geoff Chong.;Andrew Scott Paulson.;Toshiki Masuishi.;Jeremy Jones.;Tibor Csőszi.;Chiara Cremolini.;Francois Ghiringhelli.;Ardaman Shergill.;Howard S Hochster.;John Krauss.;Ali Bassam.;Michel Ducreux.;Anneli Elme.;Laurence Faugeras.;Stefan Kasper.;Eric Van Cutsem.;Dirk Arnold.;Shivani Nanda.;Zhao Yang.;William R Schelman.;Marek Kania.;Josep Tabernero.;Cathy Eng.; .
来源: Lancet. 2023年402卷10395期41-53页
There is a paucity of effective systemic therapy options for patients with advanced, chemotherapy-refractory colorectal cancer. We aimed to evaluate the efficacy and safety of fruquintinib, a highly selective and potent oral inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2, and 3, in patients with heavily pretreated metastatic colorectal cancer.
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