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3944. Human Papillomavirus Vaccination.
A 24-year-old woman is being seen for routine health care. She has not received any vaccinations against human papillomavirus (HPV). The patient initiated sexual activity at 18 years of age and has had three male sex partners. What would you recommend regarding HPV vaccination?
3945. Racial Inequality in Receipt of Medications for Opioid Use Disorder.
作者: Michael L Barnett.;Ellen Meara.;Terri Lewinson.;Brianna Hardy.;Deanna Chyn.;Moraa Onsando.;Haiden A Huskamp.;Ateev Mehrotra.;Nancy E Morden.
来源: N Engl J Med. 2023年388卷19期1779-1789页
Since 2010, Black persons in the United States have had a greater increase in opioid overdose-related mortality than other groups, but national-level evidence characterizing racial and ethnic disparities in the use of medications for opioid use disorder (OUD) is limited.
3946. Cabozantinib plus Nivolumab and Ipilimumab in Renal-Cell Carcinoma.
作者: Toni K Choueiri.;Thomas Powles.;Laurence Albiges.;Mauricio Burotto.;Cezary Szczylik.;Bogdan Zurawski.;Eduardo Yanez Ruiz.;Marco Maruzzo.;Alberto Suarez Zaizar.;Luis E Fein.;Fabio A Schutz.;Daniel Y C Heng.;Fong Wang.;Fabio Mataveli.;Yu-Lin Chang.;Maximiliano van Kooten Losio.;Cristina Suarez.;Robert J Motzer.; .
来源: N Engl J Med. 2023年388卷19期1767-1778页
The efficacy and safety of treatment with cabozantinib in combination with nivolumab and ipilimumab in patients with previously untreated advanced renal-cell carcinoma are unknown.
3947. Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy.
作者: Matthew Greenhawt.;Sayantani B Sindher.;Julie Wang.;Michael O'Sullivan.;George du Toit.;Edwin H Kim.;Deborah Albright.;Sara Anvari.;Nicolette Arends.;Peter D Arkwright.;Philippe Bégin.;Katharina Blumchen.;Thierry Bourrier.;Terri Brown-Whitehorn.;Heather Cassell.;Edmond S Chan.;Christina E Ciaccio.;Antoine Deschildre.;Amandine Divaret-Chauveau.;Stacy L Dorris.;Morna J Dorsey.;Thomas Eiwegger.;Michel Erlewyn-Lajeunesse.;David M Fleischer.;Lara S Ford.;Maria Garcia-Lloret.;Lisa Giovannini-Chami.;Jonathan O Hourihane.;Nicola Jay.;Stacie M Jones.;Leigh Ann Kerns.;Kirsten M Kloepfer.;Stephanie Leonard.;Guillaume Lezmi.;Jay A Lieberman.;Jeanne Lomas.;Melanie Makhija.;Christopher Parrish.;Jane Peake.;Kirsten P Perrett.;Daniel Petroni.;Wolfgang Pfützner.;Jacqueline A Pongracic.;Patrick Quinn.;Rachel G Robison.;Georgiana Sanders.;Lynda Schneider.;Hemant P Sharma.;Juan Trujillo.;Paul J Turner.;Katherine Tuttle.;Julia E Upton.;Pooja Varshney.;Brian P Vickery.;Christian Vogelberg.;Brynn Wainstein.;Robert A Wood.;Katharine J Bee.;Dianne E Campbell.;Todd D Green.;Rihab Rouissi.;Aurélie Peillon.;Henry T Bahnson.;Timothée Bois.;Hugh A Sampson.;A Wesley Burks.
来源: N Engl J Med. 2023年388卷19期1755-1766页
No approved treatment for peanut allergy exists for children younger than 4 years of age, and the efficacy and safety of epicutaneous immunotherapy with a peanut patch in toddlers with peanut allergy are unknown.
3948. First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia.
作者: Barbara Eichhorst.;Carsten U Niemann.;Arnon P Kater.;Moritz Fürstenau.;Julia von Tresckow.;Can Zhang.;Sandra Robrecht.;Michael Gregor.;Gunnar Juliusson.;Patrick Thornton.;Philipp B Staber.;Tamar Tadmor.;Vesa Lindström.;Caspar da Cunha-Bang.;Christof Schneider.;Christian B Poulsen.;Thomas Illmer.;Björn Schöttker.;Thomas Nösslinger.;Ann Janssens.;Ilse Christiansen.;Michael Baumann.;Henrik Frederiksen.;Marjolein van der Klift.;Ulrich Jäger.;Maria B L Leys.;Mels Hoogendoorn.;Kourosh Lotfi.;Holger Hebart.;Tobias Gaska.;Harry Koene.;Lisbeth Enggaard.;Jereon Goede.;Josien C Regelink.;Anouk Widmer.;Florian Simon.;Nisha De Silva.;Anna-Maria Fink.;Jasmin Bahlo.;Kirsten Fischer.;Clemens-Martin Wendtner.;Karl A Kreuzer.;Matthias Ritgen.;Monika Brüggemann.;Eugen Tausch.;Mark-David Levin.;Marinus van Oers.;Christian Geisler.;Stephan Stilgenbauer.;Michael Hallek.; .
来源: N Engl J Med. 2023年388卷19期1739-1754页
Randomized trials of venetoclax plus anti-CD20 antibodies as first-line treatment in fit patients (i.e., those with a low burden of coexisting conditions) with advanced chronic lymphocytic leukemia (CLL) have been lacking.
3949. Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage.
作者: Ioannis Gallos.;Adam Devall.;James Martin.;Lee Middleton.;Leanne Beeson.;Hadiza Galadanci.;Fadhlun Alwy Al-Beity.;Zahida Qureshi.;G Justus Hofmeyr.;Neil Moran.;Sue Fawcus.;Lumaan Sheikh.;George Gwako.;Alfred Osoti.;Ashraf Aswat.;Kristie-Marie Mammoliti.;Kulandaipalayam N Sindhu.;Marcelina Podesek.;Isobelle Horne.;Rebecca Timms.;Idnan Yunas.;Jenipher Okore.;Mandisa Singata-Madliki.;Edna Arends.;Aminu A Wakili.;Ard Mwampashi.;Sidrah Nausheen.;Shah Muhammad.;Pallavi Latthe.;Cherrie Evans.;Shahinoor Akter.;Gillian Forbes.;David Lissauer.;Shireen Meher.;Andrew Weeks.;Andrew Shennan.;Anne Ammerdorffer.;Eleanor Williams.;Tracy Roberts.;Mariana Widmer.;Olufemi T Oladapo.;Fabiana Lorencatto.;Meghan A Bohren.;Suellen Miller.;Fernando Althabe.;Metin Gülmezoglu.;Jeffrey M Smith.;Karla Hemming.;Arri Coomarasamy.
来源: N Engl J Med. 2023年389卷1期11-21页
Delays in the detection or treatment of postpartum hemorrhage can result in complications or death. A blood-collection drape can help provide objective, accurate, and early diagnosis of postpartum hemorrhage, and delayed or inconsistent use of effective interventions may be able to be addressed by a treatment bundle.
3956. Treatment of Gestational Diabetes Mellitus Diagnosed Early in Pregnancy.
作者: David Simmons.;Jincy Immanuel.;William M Hague.;Helena Teede.;Christopher J Nolan.;Michael J Peek.;Jeff R Flack.;Mark McLean.;Vincent Wong.;Emily Hibbert.;Alexandra Kautzky-Willer.;Jürgen Harreiter.;Helena Backman.;Emily Gianatti.;Arianne Sweeting.;Viswanathan Mohan.;Joanne Enticott.;N Wah Cheung.; .
来源: N Engl J Med. 2023年388卷23期2132-2144页
Whether treatment of gestational diabetes before 20 weeks' gestation improves maternal and infant health is unclear.
3958. Familial Clonal Hematopoiesis in a Long Telomere Syndrome.
作者: Emily A DeBoy.;Michael G Tassia.;Kristen E Schratz.;Stephanie M Yan.;Zoe L Cosner.;Emily J McNally.;Dustin L Gable.;Zhimin Xiang.;David B Lombard.;Emmanuel S Antonarakis.;Christopher D Gocke.;Rajiv C McCoy.;Mary Armanios.
来源: N Engl J Med. 2023年388卷26期2422-2433页
Telomere shortening is a well-characterized cellular aging mechanism, and short telomere syndromes cause age-related disease. However, whether long telomere length is advantageous is poorly understood.
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