3937. Adjuvant immunotherapy with nivolumab versus observation in completely resected Merkel cell carcinoma (ADMEC-O): disease-free survival results from a randomised, open-label, phase 2 trial.
作者: Jürgen C Becker.;Selma Ugurel.;Ulrike Leiter.;Friedegund Meier.;Ralf Gutzmer.;Sebastian Haferkamp.;Lisa Zimmer.;Elisabeth Livingstone.;Thomas K Eigentler.;Axel Hauschild.;Felix Kiecker.;Jessica C Hassel.;Peter Mohr.;Michael Fluck.;Ioannis Thomas.;Marlene Garzarolli.;Imke Grimmelmann.;Konstantin Drexler.;Alexandra N Spillner.;Sebastian Eckhardt.;Dirk Schadendorf.; .
来源: Lancet. 2023年402卷10404期798-808页
Merkel cell carcinoma (MCC) is an immunogenic but aggressive skin cancer. Even after complete resection and radiation, relapse rates are high. PD-1 and PD-L1 checkpoint inhibitors showed clinical benefit in advanced MCC. We aimed to assess efficacy and safety of adjuvant immune checkpoint inhibition in completely resected MCC (ie, a setting without an established systemic standard-of-care treatment).
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