3925. Emodepside for Trichuris trichiura and Hookworm Infection.
作者: Emmanuel C Mrimi.;Sophie Welsche.;Said M Ali.;Jan Hattendorf.;Jennifer Keiser.
来源: N Engl J Med. 2023年388卷20期1863-1875页
Current treatments for soil-transmitted helminth infections in humans have low efficacy against Trichuris trichiura. Emodepside - a drug in veterinary use and under development for the treatment of onchocerciasis in humans - is a leading therapeutic candidate for soil-transmitted helminth infection.
3926. A Phase 2 Trial of Peresolimab for Adults with Rheumatoid Arthritis.
作者: Jay Tuttle.;Edit Drescher.;Jesus Abraham Simón-Campos.;Paul Emery.;Maria Greenwald.;Alan Kivitz.;Hyungmin Rha.;Pia Yachi.;Christina Kiley.;Ajay Nirula.
来源: N Engl J Med. 2023年388卷20期1853-1862页
Peresolimab is a humanized IgG1 monoclonal antibody designed to stimulate the endogenous programmed cell death protein 1 (PD-1) inhibitory pathway. Stimulation of this pathway would be a novel approach to the treatment of patients with autoimmune or autoinflammatory diseases.
3927. Single-Dose Rifapentine in Household Contacts of Patients with Leprosy.
作者: Le Wang.;Hongsheng Wang.;Liangbin Yan.;Meiwen Yu.;Jun Yang.;Jinlan Li.;Junhua Li.;Yong Ning.;Haiqin Jiang.;Ying Shi.;Wenyue Zhang.;Li Xiong.;Jie Liu.;Yanfei Kuang.;Hao Wang.;Jun He.;De Wang.;Bin Li.;Yangying Liu.;Tiejun Shui.;Ying Wang.;Huan Chen.;Xiaowei Sha.;Heng Long.;Xiaojin Yu.;Chong Shen.;Jianping Shen.;Xueyuan Yang.;Heng Gu.;Guocheng Zhang.;Baoxi Wang.
来源: N Engl J Med. 2023年388卷20期1843-1852页
Previous studies have suggested that a single dose of rifampin has protective effects against leprosy in close contacts of patients with the disease. Rifapentine was shown to have greater bactericidal activity against Mycobacterium leprae than rifampin in murine models of leprosy, but data regarding its effectiveness in preventing leprosy are lacking.
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