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3856. Capivasertib in Hormone Receptor-Positive Advanced Breast Cancer.
作者: Nicholas C Turner.;Mafalda Oliveira.;Sacha J Howell.;Florence Dalenc.;Javier Cortes.;Henry L Gomez Moreno.;Xichun Hu.;Komal Jhaveri.;Petr Krivorotko.;Sibylle Loibl.;Serafin Morales Murillo.;Meena Okera.;Yeon Hee Park.;Joohyuk Sohn.;Masakazu Toi.;Eriko Tokunaga.;Samih Yousef.;Lyudmila Zhukova.;Elza C de Bruin.;Lynda Grinsted.;Gaia Schiavon.;Andrew Foxley.;Hope S Rugo.; .
来源: N Engl J Med. 2023年388卷22期2058-2070页
AKT pathway activation is implicated in endocrine-therapy resistance. Data on the efficacy and safety of the AKT inhibitor capivasertib, as an addition to fulvestrant therapy, in patients with hormone receptor-positive advanced breast cancer are limited.
3857. Ultrasonography or Radiography for Suspected Pediatric Distal Forearm Fractures.
作者: Peter J Snelling.;Philip Jones.;David Bade.;Randy Bindra.;Joshua Byrnes.;Michelle Davison.;Shane George.;Mark Moore.;Gerben Keijzers.;Robert S Ware.; .
来源: N Engl J Med. 2023年388卷22期2049-2057页
Data on whether ultrasonography for the initial diagnostic imaging of forearm fractures in children and adolescents is noninferior to radiography for subsequent physical function of the arm are limited.
3858. Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion.
作者: Wenjie Zi.;Jiaxing Song.;Weilin Kong.;Jiacheng Huang.;Changwei Guo.;Wencheng He.;Yinquan Yu.;Bo Zhang.;Wanjie Geng.;Xiaolin Tan.;Yaoyu Tian.;Zongtao Liu.;Minghua Cao.;Daoyou Cheng.;Bo Li.;Wenguo Huang.;Junsheng Liu.;Pengfei Wang.;Zhou Yu.;Hao Liang.;Shuang Yang.;Mingshan Tang.;Wenhua Liu.;Xianjun Huang.;Shugai Liu.;Yufeng Tang.;Youlin Wu.;Li Yao.;Zhu Shi.;Pengcheng He.;Haojin Zhao.;Zhuo Chen.;Jun Luo.;Yue Wan.;Qiang Shi.;Maorong Wang.;De Yang.;Xianglin Chen.;Fang Huang.;Jinlin Mu.;Hao Li.;Zhimin Li.;Jingbang Zheng.;Shunli Xie.;Tieying Cai.;Yuqi Peng.;Weihua Xie.;Zhongming Qiu.;Chang Liu.;Chengsong Yue.;Linyu Li.;Yan Tian.;Dahong Yang.;Jian Miao.;Jie Yang.;Jinrong Hu.;Raul G Nogueira.;Duolao Wang.;Jeffrey L Saver.;Fengli Li.;Qingwu Yang.; .
来源: N Engl J Med. 2023年388卷22期2025-2036页
The effects of the glycoprotein IIb/IIIa receptor inhibitor tirofiban in patients with acute ischemic stroke but who have no evidence of complete occlusion of large or medium-sized vessels have not been extensively studied.
3859. Variant STAT4 and Response to Ruxolitinib in an Autoinflammatory Syndrome.
作者: Hratch Baghdassarian.;Sarah A Blackstone.;Owen S Clay.;Rachael Philips.;Brynja Matthiasardottir.;Michele Nehrebecky.;Vivian K Hua.;Rachael McVicar.;Yang Liu.;Suzanne M Tucker.;Davide Randazzo.;Natalie Deuitch.;Sofia Rosenzweig.;Adam Mark.;Roman Sasik.;Kathleen M Fisch.;Pallavi Pimpale Chavan.;Elif Eren.;Norman R Watts.;Chi A Ma.;Massimo Gadina.;Daniella M Schwartz.;Anwesha Sanyal.;Giffin Werner.;David R Murdock.;Nobuyuki Horita.;Shimul Chowdhury.;David Dimmock.;Kristen Jepsen.;Elaine F Remmers.;Raphaela Goldbach-Mansky.;William A Gahl.;John J O'Shea.;Joshua D Milner.;Nathan E Lewis.;Johanna Chang.;Daniel L Kastner.;Kathryn Torok.;Hirotsugu Oda.;Christopher D Putnam.;Lori Broderick.
来源: N Engl J Med. 2023年388卷24期2241-2252页
Disabling pansclerotic morphea (DPM) is a rare systemic inflammatory disorder, characterized by poor wound healing, fibrosis, cytopenias, hypogammaglobulinemia, and squamous-cell carcinoma. The cause is unknown, and mortality is high.
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