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3821. Protocol of a randomized, double-blind, placebo-controlled study of the effect of probiotics on the gut microbiome of patients with gastro-oesophageal reflux disease treated with rabeprazole.
作者: Wenjun Liu.;Yong Xie.;Yingmeng Li.;Longjin Zheng.;Qiuping Xiao.;Xu Zhou.;Qiong Li.;Ni Yang.;Kexuan Zuo.;Tielong Xu.;Nong-Hua Lu.;Heping Zhang.
来源: BMC Gastroenterol. 2022年22卷1期255页
For patients with gastro-oesophageal reflux symptoms, the preferred treatment is proton pump inhibitor (PPI) administration for approximately 8 weeks. However, long-term use of PPIs can cause gut microbiome (GM) disturbances. This study is designed to evaluate the effect of probiotics combined with a PPI on the GM and gastrointestinal symptoms of patients with gastro-oesophageal reflux disease (GERD).
3822. Unusual presentation of extra-nodal double-hit follicular lymphoma: a case report.
To the best of our knowledge, this case represents the first report of an extranodal double-hit follicular lymphoma (DH-FL) as an intestinal polypoid lesion.
3827. Induction of Fibroblast Growth Factor Receptor 4 by Helicobacter pylori via Signal Transducer and Activator of Transcription 3 With a Feedforward Activation Loop Involving SRC Signaling in Gastric Cancer.
作者: Xing Zhang.;Mohammed Soutto.;Zheng Chen.;Nadeem Bhat.;Shoumin Zhu.;Moritz F Eissmann.;Matthias Ernst.;Heng Lu.;Dunfa Peng.;Zekuan Xu.;Wael El-Rifai.
来源: Gastroenterology. 2022年163卷3期620-636.e9页
Helicobacter pylori (H pylori) infection is the main risk factor for gastric cancer. The role of fibroblast growth factor receptors (FGRFs) in H pylori-mediated gastric tumorigenesis remains largely unknown. This study investigated the molecular and mechanistic links between H pylori, inflammation, and FGFR4 in gastric cancer.
3828. Can visceral adipose tissue and skeletal muscle predict recurrence of newly diagnosed Crohn's disease in different treatments.
作者: Zinan Zhang.;Xiaoyu Yu.;Ning Fang.;Xiuyan Long.;Xixian Ruan.;Jianing Qiu.;Sifan Tao.;Pan Gong.;Kai Nie.;An Li.;Xiaoyan Wang.;Li Tian.
来源: BMC Gastroenterol. 2022年22卷1期250页
It is crucial to manage the recurrence of Crohn's disease (CD). This study is aimed to explore whether visceral adipose tissue (VAT) and skeletal muscle (SM) are associated with the recurrence of CD upon different treatments.
3829. Ultrasonographic scores for ileal Crohn's disease assessment: Better, worse or the same as contrast-enhanced ultrasound?
作者: M Freitas.;F Dias de Castro.;V Macedo Silva.;C Arieira.;T Cúrdia Gonçalves.;S Leite.;M J Moreira.;J Cotter.
来源: BMC Gastroenterol. 2022年22卷1期252页
Intestinal ultrasound (IUS) is an increasingly used non-invasive tool to evaluate Crohn's disease (CD) activity. Recently, two IUS scores that evaluate inflammatory activity have emerged: the Simple Ultrasound Activity Score for CD (SUS-CD) and the International Bowel Ultrasound Segmental Activity Score (IBUS-SAS). We aimed to compare the accuracy of SUS-CD, IBUS-SAS and contrast-enhanced ultrasound (CEUS) in predicting inflammatory activity in the terminal ileum in ileocolonoscopy in CD patients.
3830. Comparison of fully coated anti-reflux metal stenting and per-oral endoscopic myotomy in patients with achalasia: a propensity score-matched retrospective study.
作者: Yu-Fen Tang.;Peng Jin.;Yu-Rong Tao.;Hui Xie.;Xin Wang.;Dongliang Yu.;Shan Tang.;Jian-Qiu Sheng.
来源: BMC Gastroenterol. 2022年22卷1期253页
Achalasia is a rare primary esophageal motility disorder disease. It is reported that the long-term effect of fully coated anti-reflux metal stent (FCARMS) implantation is satisfactory. Operated by a skilled and experienced endoscopist, the effect of per-oral endoscopic myotomy (POEM) treatment is equivalent to that of surgical myotomy. So far, there is still few evidence to prove FCARMS implantation or POEM which is better for achalasia. The choice of treatment for achalasia is still controversial. The aim of this study is to find a more suitable therapy for achalasia by comparing the efficacy of FCARMS implantation and POEM.
3831. Multimodal intervention to improve the transition of patients with inflammatory bowel disease from pediatric to adult care: protocol for a randomized controlled trial.
作者: Natasha Bollegala.;Melanie Barwick.;Nancy Fu.;Anne M Griffiths.;Laurie Keefer.;Sara Ahola Kohut.;Karen I Kroeker.;Sally Lawrence.;Kate Lee.;David R Mack.;Thomas D Walters.;Jacqueline de Guzman.;Claudia Tersigni.;Ashleigh Miatello.;Eric I Benchimol.
来源: BMC Gastroenterol. 2022年22卷1期251页
Transition in care is defined as the "purposeful and planned movement of adolescents and young adults with a chronic medical condition from pediatric to adult-oriented healthcare systems/care providers." Currently, there are no Level 1 evidence-based interventions to improve the care of transitioning adolescents and young adults (AYAs) with inflammatory bowel disease (IBD). The development of a transition program using a biopsychosocial approach will improve the standards for healthcare delivery to transitioning IBD patients. This is a protocol for a structured randomized controlled trial (RCT) to assess the clinical and implementation effectiveness of a multimodal intervention focused on improving patient function, transition readiness and outcomes among AYA patients with IBD being cared for at pediatric centers in Canada.
3833. Association of neutrophil to lymphocyte ratio with preterm necrotizing enterocolitis: a retrospective case-control study.
There have been few studies on the relationship between the neutrophil to lymphocyte ratio (NLR) and necrotizing enterocolitis (NEC). We conducted a retrospective case-control study to investigate this relationship in preterm neonates.
3835. Endoscopic Versus Surgical Step-Up Approach for Infected Necrotizing Pancreatitis (ExTENSION): Long-term Follow-up of a Randomized Trial.
作者: Anke M Onnekink.;Lotte Boxhoorn.;Hester C Timmerhuis.;Simon T Bac.;Marc G Besselink.;Marja A Boermeester.;Thomas L Bollen.;Koop Bosscha.;Stefan A W Bouwense.;Marco J Bruno.;Sandra van Brunschot.;Vincent C Cappendijk.;Esther C J Consten.;Cornelis H Dejong.;Marcel G W Dijkgraaf.;Casper H J van Eijck.;Willemien G Erkelens.;Harry van Goor.;Janneke van Grinsven.;Jan-Willem Haveman.;Jeanin E van Hooft.;Jeroen M Jansen.;Krijn P van Lienden.;Maarten A C Meijssen.;Vincent B Nieuwenhuijs.;Jan-Werner Poley.;Rutger Quispel.;Rogier J de Ridder.;Tessa E H Römkens.;Hjalmar C van Santvoort.;Joris J Scheepers.;Matthijs P Schwartz.;Tom Seerden.;Marcel B W Spanier.;Jan Willem A Straathof.;Robin Timmer.;Niels G Venneman.;Robert C Verdonk.;Frank P Vleggaar.;Roy L van Wanrooij.;Ben J M Witteman.;Paul Fockens.;Rogier P Voermans.; .
来源: Gastroenterology. 2022年163卷3期712-722.e14页
Previous randomized trials, including the Transluminal Endoscopic Step-Up Approach Versus Minimally Invasive Surgical Step-Up Approach in Patients With Infected Pancreatic Necrosis (TENSION) trial, demonstrated that the endoscopic step-up approach might be preferred over the surgical step-up approach in patients with infected necrotizing pancreatitis based on favorable short-term outcomes. We compared long-term clinical outcomes of both step-up approaches after a period of at least 5 years.
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