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3801. Odevixibat Treatment Induces Biliary Bile Acid Secretion in Responsive Patients With Bile Salt Export Pump Deficiency.
作者: Mark Nomden.;Folkert Kuipers.;Jan B F Hulscher.;Erik Lindström.;Velichka Valcheva.;Henkjan J Verkade.
来源: Gastroenterology. 2023年165卷2期496-498.e1页 3803. Correction to: Prognostic significance of serum CA125 in the overall management for patients with gastrointestinal stromal tumors.
作者: Chao Sui.;Chen Lin.;Tingting Tao.;Wenxian Guan.;Haoran Zhang.;Liang Tao.;Meng Wang.;Feng Wang.
来源: BMC Gastroenterol. 2023年23卷1期98页 3804. The effect of biological agent on body composition in patients with Crohn's disease.
作者: Eun Jeong Choi.;Dong Hoon Baek.;Hong Sub Lee.;Geun Am Song.;Tae Oh Kim.;Yong Eun Park.;Chang Min Lee.; .;Jong Hoon Lee.
来源: BMC Gastroenterol. 2023年23卷1期100页
Crohn's disease (CD) is associated with altered body composition, affecting clinical outcomes. We evaluated the impact of biologics on body composition in CD patients.
3805. Correction to: Correlation between serum liver fibrosis markers and early gastroesophageal varices among patients with compensated liver cirrhosis: a cross-sectional analysis.
作者: Ling Mei.;Ying Ma.;Lili Zhao.;Qingling Chen.;Li Zhou.;Hang Yang.;Jie Liu.;Jia Li.
来源: BMC Gastroenterol. 2023年23卷1期99页 3807. Developing the modified 4-item version of perceived stress scale for functional dyspepsia.
作者: Limei Du.;Guizhen Yong.;Ping Wang.;Xi Wang.;Wen Ming.;Guobin He.
来源: BMC Gastroenterol. 2023年23卷1期97页
To develop the modified 4-item version of Perceived Stress Scale (PSS) with a better reliability and validity than the 4-item version of PSS (PSS-4) in evaluating psychological stress in patients with functional dyspepsia (FD). The present study also aimed to explore the correlation between dyspepsia symptoms severity (DSS), anxiety, depression, somatization, quality of life (QoL), and psychological stress assessed by two approaches in FD.
3808. Transmission of the Potential Pathogen Atypical Enteropathogenic Escherichia coli by Fecal Microbiota Transplant.
作者: Sarah E Kralicek.;Celeste Jenkins.;Jessica R Allegretti.;James D Lewis.;Majdi Osman.;Gail A Hecht.
来源: Gastroenterology. 2023年165卷1期279-282.e1页 3809. A-to-I RNA-Editing: An Epigenetic Hallmark Cannot Be Ignored in Silencing the Tumor Microenvironment and Is Promising in Predicting Immunotherapy Response for Esophageal Squamous Cell Carcinoma.
作者: Sihui Wang.;Chengming Liu.;Chaoqi Zhang.;Liyan Xue.;Nan Sun.;Jie He.
来源: Gastroenterology. 2023年165卷1期275-278.e8页 3810. Analysis of clinical diagnosis and treatment of intestinal volvulus.
The aim of this study is to investigate the clinical characteristics and treatment experience of intestinal volvulus, and to analyze the incidence of adverse events and related risk factors of intestinal volvulus.
3811. Utility of monocyte distribution width in the differential diagnosis between simple and complicated diverticulitis: a retrospective cohort study.
作者: Chang-Yuan Chang.;Tai-Yi Hsu.;Guan-Yi He.;Hong-Mo Shih.;Shih-Hao Wu.;Fen-Wei Huang.;Pei-Chun Chen.;Wen-Chen Tsai.
来源: BMC Gastroenterol. 2023年23卷1期96页
Colonic diverticulitis is a leading cause of abdominal pain. The monocyte distribution width (MDW) is a novel inflammatory biomarker with prognostic significance for coronavirus disease and pancreatitis; however, no study has assessed its correlation with the severity of colonic diverticulitis.
3812. Thiols as a marker of inflammatory bowel disease activity: a systematic review.
作者: Rebeca Araujo Passos.;Priscila Ribas Farias Costa.;Claudia Feio da Maia Lima.;George Mariane Soares Santana.;Victor David.;Geisa de Jesus Santos.;Cyrla Zaltman.;Marcia Soares-Mota.;Raquel Rocha.
来源: BMC Gastroenterol. 2023年23卷1期94页
Evidence indicates that inflammation in Inflammatory Bowel Disease (IBD) is associated with increased systemic levels of reactive oxygen species. Systemic oxidative stress has been associated with reduced levels of plasma thiols. Less invasive tests capable of reflecting and predicting IBD activity are increasingly sought after. We sought to systematically review the evidence inherent in serum thiol levels as a marker of Crohn's Disease and Ulcerative Colitis activity (PROSPERO: CRD42021255521).
3813. APC mutation correlated with poor response of immunotherapy in colon cancer.
APC (adenomatous polyposis coli) gene mutation is a central initialization in colon cancer tumorigenesis. However, the connection between APC gene mutation and immunotherapy efficacy for colon cancer remains unknown. This study aimed to explore the impact of APC mutation on immunotherapy efficacy for colon cancer.
3814. Comparison of clinical and pathological features between early-stage gastric-type and intestinal-type differentiated adenocarcinoma: a retrospective study.
作者: Borui Li.;Tingting Chen.;Dingbao Liang.;Yin Zhang.;Xiwei Ding.;Ying Lv.
来源: BMC Gastroenterol. 2023年23卷1期92页
The clinicopathological features and endoscopic characteristics under magnifying endoscopy with narrow band imaging (ME-NBI) between early-stage gastric-type differentiated adenocarcinoma (GDA) and intestinal-type differentiated adenocarcinoma (IDA) remain controversial.
3815. Correlation between nonalcoholic fatty liver disease and left ventricular diastolic dysfunction in non-obese adults: a cross-sectional study.
作者: Fangyuan Cong.;Luying Zhu.;Lihua Deng.;Qian Xue.;Jingtong Wang.
来源: BMC Gastroenterol. 2023年23卷1期90页
Non-alcoholic fatty liver disease (NAFLD) is associated with a greater risk of developing cardiovascular disease and have adverse impacts on the cardiac structure and function. Little is known about the effect of non-obese NAFLD upon cardiac function. We aimed to compare the echocardiographic parameters of left ventricle (LV) between non-obese NAFLD group and control group, and explore the correlation of non-obese NAFLD with LV diastolic dysfunction.
3816. Impact of cholangitis on survival of patients with malignant biliary obstruction treated with percutaneous transhepatic biliary drainage.
作者: Jarmo Niemelä.;Raija Kallio.;Pasi Ohtonen.;Juha Saarnio.;Hannu Syrjälä.
来源: BMC Gastroenterol. 2023年23卷1期91页
To evaluate the impact of cholangitis on survival of patients with gastrointestinal cancer and malignant biliary obstruction treated with percutaneous transhepatic biliary drainage (PTBD).
3817. A novel predictive model of microvascular invasion in hepatocellular carcinoma based on differential protein expression.
作者: Zhenglu Wang.;Lei Cao.;Jianxi Wang.;Hanlin Wang.;Tingting Ma.;Zhiqi Yin.;Wenjuan Cai.;Lei Liu.;Tao Liu.;Hengde Ma.;Yamin Zhang.;Zhongyang Shen.;Hong Zheng.
来源: BMC Gastroenterol. 2023年23卷1期89页
This study aims to construct and verify a nomogram model for microvascular invasion (MVI) based on hepatocellular carcinoma (HCC) tumor characteristics and differential protein expressions, and explore the clinical application value of the prediction model.
3818. Proteomic Profiling of Colorectal Adenomas Identifies a Predictive Risk Signature for Development of Metachronous Advanced Colorectal Neoplasia.
作者: Jacob Mathias Bech.;Thilde Terkelsen.;Annette Snejbjerg Bartels.;Fabian Coscia.;Sophia Doll.;Siqi Zhao.;Zhaojun Zhang.;Nils Brünner.;Jan Lindebjerg.;Gunvor Iben Madsen.;Xiangdong Fang.;Matthias Mann.;José Manuel Afonso Moreira.
来源: Gastroenterology. 2023年165卷1期121-132.e5页
Colonic adenomatous polyps, or adenomas, are frequent precancerous lesions and the origin of most cases of colorectal adenocarcinoma. However, we know from epidemiologic studies that although most colorectal cancers (CRCs) originate from adenomas, only a small fraction of adenomas (3%-5%) ever progress to cancer. At present, there are no molecular markers to guide follow-up surveillance programs.
3820. ARBM101 (Methanobactin SB2) Drains Excess Liver Copper via Biliary Excretion in Wilson's Disease Rats.
作者: Claudia Einer.;Ditte Emilie Munk.;Eok Park.;Banu Akdogan.;Judith Nagel.;Josef Lichtmannegger.;Carola Eberhagen.;Tamara Rieder.;Mikkel H Vendelbo.;Bernhard Michalke.;Ralf Wimmer.;Andreas Blutke.;Annette Feuchtinger.;Philip Dershwitz.;Ana M DiSpirito.;Tawhidul Islam.;Rui E Castro.;Byong-Keol Min.;TaeWon Kim.;Seoyoung Choi.;Dasol Kim.;Chunwon Jung.;Hongjae Lee.;Dongsik Park.;Weonbin Im.;So-Young Eun.;You-Hee Cho.;Jeremy D Semrau.;Cecília M P Rodrigues.;Simon Hohenester.;Thomas Damgaard Sandahl.;Alan A DiSpirito.;Hans Zischka.
来源: Gastroenterology. 2023年165卷1期187-200.e7页
Excess copper causes hepatocyte death in hereditary Wilson's disease (WD). Current WD treatments by copper-binding chelators may gradually reduce copper overload; they fail, however, to bring hepatic copper close to normal physiological levels. Consequently, lifelong daily dose regimens are required to hinder disease progression. This may result in severe issues due to nonadherence or unwanted adverse drug reactions and also due to drug switching and ultimate treatment failures. This study comparatively tested bacteria-derived copper binding agents-methanobactins (MBs)-for efficient liver copper depletion in WD rats as well as their safety and effect duration.
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