Exposure to Benzo[a]pyrene (BaP) is linked to multiple autoimmune diseases. This study aims to identify the key genes associated with BaP exposure and primary biliary cholangitis (PBC), shedding light on the underlying molecular mechanisms.

Individuals with colorectal polyposis are suspected to be genetically predisposed to tumor development. However, in around half of adenomatous and the vast majority of serrated polyposis patients, no explanatory pathogenic germline variant is found in routine diagnostics. Here, we aimed to improve the characterization of the early steps of polyp formation and provide clues on the tumorigenic processes involved.

Pancreatitis, a debilitating disease, is orchestrated by many etiological factors. Besides the known causal genes, including PRSS1, SPINK1, CPA1, CFTR, etc., of late, TRPV6 has emerged as a new candidate in the list. We aimed to investigate the role of TRPV6 and its genetic variations in the etiopathology of pancreatitis.

Postprocedural pancreatitis is the most common adverse event (AE) associated with endoscopic retrograde cholangiopancreatography (ERCP). Endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) using a lumen-apposing metal stent is emerging as a promising approach for managing malignant distal biliary obstruction, offering the potential to lower the risk of postprocedural pancreatitis.

Acute severe ulcerative colitis is a potentially life-threatening condition that requires hospitalization with early and aggressive intervention to prevent complications. Mirikizumab (an anti-IL-23 monoclonal antibody) is recommended for the treatment of adult patients with moderate-to-severe ulcerative colitis. Currently, there is lack of evidence supporting its use in acute severe colitis, and no evidence has been produced on the use of this medication in pregnant women. A 30-year-old pregnant woman, with a 4-year history of corticosteroid-refractory pancolitis, who had failure to respond to multiple biological therapies, including infliximab, adalimumab, and vedolizumab, presented with acute severe ulcerative colitis and suspected threatened preterm rupture of membranes at 18 weeks' gestation. After administering five days of intravenous corticosteroids, the patient showed an unfavorable clinical and endoscopic response. Given the corticosteroid-refractory ASUC and the significant obstetric and neonatal risks associated with colectomy, Mirikizumab was initiated as a rescue therapy. Remarkably, within one day of receiving the first dose, the patient exhibited significant clinical improvement. One month after Mirikizumab initiation, the patient maintained clinical remission with improved markers. At 35 weeks and 4 days of gestation, the patient underwent an urgent cesarean section, delivering a preterm female infant. This is the first reported case regarding the efficacy and safety of Mirikizumab as a rescue therapy in a pregnant woman with severe acute ulcerative colitis. Further research is needed to confirm its efficacy in ASUC and the safety of this drug during pregnancy.

This study investigated the association between depression and the incidence of gastro-oesophageal reflux disease (GERD) and examined whether the association interacts with age. The analysis was based on 457,958 participants aged 37–73 years from the UK-Biobank prospective cohort study.

Laparoscopic repair of gastroduodenal perforation has been widely used in clinical practice. With the advent of barbed sutures, the position of traditional absorbable sutures has been challenged, but the superiority of one over the other in terms of clinical outcomes remains unclear.

Health-related quality of life (HRQoL) is central to the management of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), yet domain-specific determinants remain underdefined in real-world settings. We aimed to identify phenotype-specific determinants of total and domain-level HRQoL in a real-world Palestinian cohort of patients with CD and UC.

In our study, we aimed to investigate the effect of PPI use on peritonitis, and hepatic encephalopathy in patients with liver cirrhosis.

The incidence of autoimmune gastritis (AIG) is low, and our understanding of the proliferation of neuroendocrine cells, specifically enterochromaffin-like (ECL) cells, is insufficient because of the reliance on chromogranin A (CgA) staining for diagnostic assistance. The purpose of this study was to analyze the morphological characteristics of neuroendocrine cell hyperplasia in H&E-stained sections and improve pathologists' diagnostic accuracy in its identification.

Partial hepatectomy (PH) may increase the risk of myocardial injury after non-cardiac surgery (MINS), a complication associated with substantial perioperative morbidity and mortality. Direct comparisons of MINS incidence between PH and other major abdominal surgeries (MAS) remain limited. This study evaluated whether PH confers greater risk of postoperative MINS compared with other MAS.

Endoscopic ultrasound (EUS) has evolved from a diagnostic imaging tool into a versatile platform that enables high-precision access, sampling, and therapy across gastrointestinal and hepatobiliary diseases. This review summarizes recent advances that are reshaping diagnostic practice and theragnostics. In chronic pancreatitis, EUS remains central when cross-sectional imaging is equivocal; secretin-stimulated endoscopic pancreatic function testing can complement morphology, although discordant results limit standalone certainty. For pancreatic cancer, secretin-stimulated duodenal pancreatic-juice collection enables "liquid biopsy" analyses-including methylated DNA markers and extracellular-vesicle microRNAs-that augment carbohydrate antigen 19-9 and may enhance early detection and cyst surveillance. In endohepatology, EUS-guided portal pressure gradient measurement and liver biopsy offer accurate, same-session assessment with strong safety profiles. Adjunctive imaging-contrast-enhanced EUS and elastography-improves lesion characterization and targeting. Tissue acquisition has shifted toward end-cutting fine-needle biopsy needles, optimized by fanning/torque techniques, wet-suction, and macroscopic/visual on-site evaluation, reducing passes while preserving molecular adequacy. Artificial intelligence is emerging across workflows-from differentiating pancreatic lesions and staging to automating standardized photodocumentation and reporting-and is being explored for needle-based confocal laser endomicroscopy image interpretation. For pancreatic cysts, glucose, selected genomics (eg, KRAS/GNAS and targeted panels), and through-the-needle biopsy refine diagnosis. Finally, EUS-obtained tissue now seeds organoids, patient-derived xenografts, and organotypic slice cultures to test individualized therapies. Collectively, these innovations move EUS beyond "see and biopsy" toward detect, predict, and personalize.

IgG4-related cholangitis (IRC) is an important hepatobiliary manifestation of IgG4-related diseases (IRD), frequently accompanied by other organ involvement of IRD especially autoimmune pancreatitis (AIP). Diagnosis of IRC requires comprehensive evaluation. The patients respond well to glucocorticosteroids and have good long-term prognosis regardless of relapse. This retrospective observational study described the clinical features, responses to therapy and prognosis of patients with IRC.

Abdominal bloating is a common gastrointestinal complaint, especially among women, and can significantly affect quality of life. Despite its high prevalence, the role of dietary fat intake in the development or exacerbation of bloating remains poorly characterized. This study aimed to examine the association between abdominal bloating and the consumption of various types of dietary fats among Iranian women.