3621. A Case of Fetal-Induced Graft-versus-Host Disease.
作者: Anna R Schreiber.;Jennifer Santos.;Brandon McMahon.;Tyler W Buckner.;Courtney Olson.;Michael O Alberti.;Amy Guimarães-Young.;Christopher Knoeckel.;Lindsey Broussard.;Michael Aubrey.;Brent E Palmer.;Emma Weiss.;Geoffrey R Connors.;Selene Brunner.;Joshua A Wisell.;Theresa Pacheco.;Dara L Aisner.;Jonathan A Gutman.
来源: N Engl J Med. 2023年389卷7期668-670页 3629. Gene Therapy in Patients with the Crigler-Najjar Syndrome.
作者: Lorenzo D'Antiga.;Ulrich Beuers.;Giuseppe Ronzitti.;Nicola Brunetti-Pierri.;Ulrich Baumann.;Angelo Di Giorgio.;Sem Aronson.;Aurelie Hubert.;Roberta Romano.;Norman Junge.;Piter Bosma.;Giulia Bortolussi.;Andrés F Muro.;Ravaka F Soumoudronga.;Philippe Veron.;Fanny Collaud.;Nathalie Knuchel-Legendre.;Philippe Labrune.;Federico Mingozzi.
来源: N Engl J Med. 2023年389卷7期620-631页
Patients with the Crigler-Najjar syndrome lack the enzyme uridine diphosphoglucuronate glucuronosyltransferase 1A1 (UGT1A1), the absence of which leads to severe unconjugated hyperbilirubinemia that can cause irreversible neurologic injury and death. Prolonged, daily phototherapy partially controls the jaundice, but the only definitive cure is liver transplantation.
3630. Omitting Radiotherapy after Breast-Conserving Surgery in Luminal A Breast Cancer.
作者: Timothy J Whelan.;Sally Smith.;Sameer Parpia.;Anthony W Fyles.;Anita Bane.;Fei-Fei Liu.;Eileen Rakovitch.;Lynn Chang.;Christiaan Stevens.;Julie Bowen.;Sawyna Provencher.;Valerie Théberge.;Anna Marie Mulligan.;Zuzana Kos.;Mohamed A Akra.;K David Voduc.;Tarek Hijal.;Ian S Dayes.;Gregory Pond.;James R Wright.;Torsten O Nielsen.;Mark N Levine.; .
来源: N Engl J Med. 2023年389卷7期612-619页
Adjuvant radiotherapy is prescribed after breast-conserving surgery to reduce the risk of local recurrence. However, radiotherapy is inconvenient, costly, and associated with both short-term and long-term side effects. Clinicopathologic factors alone are of limited use in the identification of women at low risk for local recurrence in whom radiotherapy can be omitted. Molecularly defined intrinsic subtypes of breast cancer can provide additional prognostic information.
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