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3582. Scoring system for predicting 90-day mortality of in-hospital liver cirrhosis patients at Cipto Mangunkusumo Hospital.
作者: Irsan Hasan.;Saut Horas Hatoguan Nababan.;Anugrah Dwi Handayu.;Gita Aprilicia.;Rino Alvani Gani.
来源: BMC Gastroenterol. 2023年23卷1期190页
Liver cirrhosis is the final stage of chronic liver disease. Complications due to progression of liver disease may deteriorate the liver function and worsen prognosis. Previous studies have shown that patients with liver cirrhosis are at increased risk of death within 90-day after hospitalization. It is necessary to identify patients who are at higher risk of early mortality. This study aims to develop a scoring system to predict the 90-day mortality among hospitalized patients with liver cirrhosis that could be used for modification of treatment plan according to the scores that have been obtained. By using this scoring system, crucial care of plans can be taken to reduce the risk of mortality.
3583. Long- and short-term outcomes of balloon dilation for benign choledochojejunal anastomotic stricture using balloon endoscopy-assisted ERCP: a multi-center retrospective cohort study.
作者: Yuhei Iwasa.;Takuji Iwashita.;Keisuke Iwata.;Shinya Uemura.;Mitsuru Okuno.;Ryuichi Tezuka.;Akihiko Senju.;Tsuyoshi Mukai.;Masahito Shimizu.
来源: BMC Gastroenterol. 2023年23卷1期191页
Benign choledochojejunal anastomotic stricture (CJS) is a common complication of pancreaticoduodenectomy and choledochojejunostomy. CJS is generally treated with balloon dilation, using balloon endoscopy-assisted endoscopic retrograde cholangiopancreatography (BE-ERCP); however, its long- and short-term outcomes have not been fully evaluated. Therefore, we evaluated the treatment outcomes of balloon dilation with BE-ERCP for CJS.
3584. Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis.
作者: Tao Zuo.;Qi Xie.;Jinfang Liu.;Jing Yang.;Jiahui Shi.;Degang Kong.;Yin Wang.;Zhenpeng Zhang.;Huixia Gao.;Dao-Bing Zeng.;Xinxin Wang.;Ping Tao.;Wei Wei.;Jun Wang.;Yuan Li.;Qi Long.;Chonghui Li.;Lei Chang.;Huimin Ning.;Yanchang Li.;Chunping Cui.;Xinlan Ge.;Jushan Wu.;Guangming Li.;Xuechuan Hong.;Xiao Yang.;Erhei Dai.;Fuchu He.;Junzhu Wu.;Yuanyuan Ruan.;Shichun Lu.;Ping Xu.
来源: Gastroenterology. 2023年165卷3期746-761.e16页
Liver fibrosis is an intrinsic wound-healing response to chronic injury and the major cause of liver-related morbidity and mortality worldwide. However, no effective diagnostic or therapeutic strategies are available, owing to its poorly characterized molecular etiology. We aimed to elucidate the mechanisms underlying liver fibrogenesis.
3585. A Medium-Chain Fatty Acid Analogue Prevents Intestinal Failure-Associated Liver Disease in Preterm Yorkshire Piglets.
作者: Scott C Fligor.;Savas T Tsikis.;Thomas I Hirsch.;Amy Pan.;Kamila Moskowitzova.;Lorena Rincon-Cruz.;Ashlyn E Whitlock.;Paul D Mitchell.;Arthur P Nedder.;Kathleen M Gura.;David A Fraser.;Mark Puder.
来源: Gastroenterology. 2023年165卷3期733-745.e9页
At least 20%-30% of patients with intestinal failure receiving long-term parenteral nutrition will develop intestinal failure-associated liver disease (IFALD), for which there are few therapeutic options. SEFA-6179 is a first-in-class structurally engineered medium-chain fatty acid analogue that acts through GPR84, PPARα, and PPARγ agonism. We hypothesized that SEFA-6179 would prevent biochemical and histologic liver injury in a preterm piglet model of IFALD.
3586. Transforming Growth Factor-β Blockade in Pancreatic Cancer Enhances Sensitivity to Combination Chemotherapy.
作者: Li Qiang.;Megan T Hoffman.;Lestat R Ali.;Jaime I Castillo.;Lauren Kageler.;Ayantu Temesgen.;Patrick Lenehan.;S Jennifer Wang.;Elisa Bello.;Victoire Cardot-Ruffino.;Giselle A Uribe.;Annan Yang.;Michael Dougan.;Andrew J Aguirre.;Srivatsan Raghavan.;Marc Pelletier.;Viviana Cremasco.;Stephanie K Dougan.
来源: Gastroenterology. 2023年165卷4期874-890.e10页
Transforming growth factor-b (TGFb) plays pleiotropic roles in pancreatic cancer, including promoting metastasis, attenuating CD8 T-cell activation, and enhancing myofibroblast differentiation and deposition of extracellular matrix. However, single-agent TGFb inhibition has shown limited efficacy against pancreatic cancer in mice or humans.
3587. A PhysioMechanical Model of Esophageal Function in Eosinophilic Esophagitis.
作者: Dustin A Carlson.;Ikuo Hirano.;Nirmala Gonsalves.;Peter J Kahrilas.;Isis K Araujo.;Mira Yang.;Marie-Pier Tetreault.;John E Pandolfino.
来源: Gastroenterology. 2023年165卷3期552-563.e4页
Eosinophilic esophagitis (EoE) is characterized by eosinophilic inflammation, but also heterogeneous presentations involving fibrostenotic esophageal remodeling and esophageal dysmotility. We aimed to define and evaluate phenotypes of EoE using functional lumen imaging probe (FLIP) panometry (ie, a PhysioMechanical classification of EoE).
3588. Gut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives.
作者: Juan Antonio Raygoza Garay.;Williams Turpin.;Sun-Ho Lee.;Michelle I Smith.;Ashleigh Goethel.;Anne M Griffiths.;Paul Moayyedi.;Osvaldo Espin-Garcia.;Maria Abreu.;Guy L Aumais.;Charles N Bernstein.;Irit A Biron.;Maria Cino.;Colette Deslandres.;Iris Dotan.;Wael El-Matary.;Brian Feagan.;David S Guttman.;Hien Huynh.;Levinus A Dieleman.;Jeffrey S Hyams.;Kevan Jacobson.;David Mack.;John K Marshall.;Anthony Otley.;Remo Panaccione.;Mark Ropeleski.;Mark S Silverberg.;A Hillary Steinhart.;Dan Turner.;Baruch Yerushalmi.;Andrew D Paterson.;Wei Xu.; .;Kenneth Croitoru.
来源: Gastroenterology. 2023年165卷3期670-681页
The cause of Crohn's disease (CD) is unknown, but the current hypothesis is that microbial or environmental factors induce gut inflammation in genetically susceptible individuals, leading to chronic intestinal inflammation. Case-control studies of patients with CD have cataloged alterations in the gut microbiome composition; however, these studies fail to distinguish whether the altered gut microbiome composition is associated with initiation of CD or is the result of inflammation or drug treatment.
3589. A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study.
作者: Barbara Pardini.;Giulio Ferrero.;Sonia Tarallo.;Gaetano Gallo.;Antonio Francavilla.;Nicola Licheri.;Mario Trompetto.;Giuseppe Clerico.;Carlo Senore.;Sergio Peyre.;Veronika Vymetalkova.;Ludmila Vodickova.;Vaclav Liska.;Ondrej Vycital.;Miroslav Levy.;Peter Macinga.;Tomas Hucl.;Eva Budinska.;Pavel Vodicka.;Francesca Cordero.;Alessio Naccarati.
来源: Gastroenterology. 2023年165卷3期582-599.e8页
Fecal tests currently used for colorectal cancer (CRC) screening show limited accuracy in detecting early tumors or precancerous lesions. In this respect, we comprehensively evaluated stool microRNA (miRNA) profiles as biomarkers for noninvasive CRC diagnosis.
3590. Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America.
作者: Alberto Queiroz Farias.;Anna Curto Vilalta.;Patricia Momoyo Zitelli.;Gustavo Pereira.;Luciana L Goncalves.;Aldo Torre.;Juan Manuel Diaz.;Adrian C Gadano.;Angelo Z Mattos.;Liliana S C Mendes.;Mario R Alvares-da-Silva.;Paulo L Bittencourt.;Carlos Benitez.;Claudia Alves Couto.;Manuel Mendizabal.;Claudio L Toledo.;Daniel F C Mazo.;Mauricio Castillo Barradas.;Eva M Uson Raposo.;P Martín Padilla-Machaca.;Adelina Zarela Lozano Miranda.;René Malé-Velázquez.;André Castro Lyra.;Milagros B Dávalos-Moscol.;José L Pérez Hernández.;Rafael O Ximenes.;Giovanni Faria Silva.;Oscar A Beltrán-Galvis.;María S González Huezo.;Fernando Bessone.;Tarciso D S Rocha.;Eduardo Fassio.;Carlos Terra.;Juan I Marín.;Patricia Sierra Casas.;Carlos de la Peña-Ramirez.;Ferran Aguilar Parera.;Flavia Fernandes.;Maria da Penha Zago-Gomes.;Osvely Méndez-Guerrero.;Sebastián Marciano.;Angelo A Mattos.;Joao C Oliveira.;Gabriel T S Guerreiro.;Liana Codes.;Marco Arrese.;Mateus J Nardelli.;Marcelo O Silva.;Renato Palma-Fernandez.;Camila Alcantara.;Cristina Sánchez Garrido.;Jonel Trebicka.;Thierry Gustot.;Javier Fernández.;Joan Clària.;Rajiv Jalan.;Paolo Angeli.;Vicente Arroyo.;Richard Moreau.;Flair J Carrilho.; .
来源: Gastroenterology. 2023年165卷3期696-716页
Genetic ancestry or racial differences in health outcomes exist in diseases associated with systemic inflammation (eg, COVID-19). This study aimed to investigate the association of genetic ancestry and race with acute-on-chronic liver failure (ACLF), which is characterized by acute systemic inflammation, multi-organ failure, and high risk of short-term death.
3591. Evaluating Different Approaches for Calculating Adenoma Detection Rate: Is Screening Colonoscopy the Gold Standard?
作者: Douglas A Corley.;Christopher D Jensen.;Jessica Chubak.;Joanne E Schottinger.;Ethan A Halm.;Natalia Udaltsova.; .
来源: Gastroenterology. 2023年165卷3期784-787.e4页 3592. Spatially Resolved Multi-Omics Single-Cell Analyses Inform Mechanisms of Immune Dysfunction in Pancreatic Cancer.
作者: Suhail Yousuf.;Mengjie Qiu.;Lena Voith von Voithenberg.;Johannes Hulkkonen.;Igor Macinkovic.;Axel R Schulz.;Domenic Hartmann.;Florian Mueller.;Margarete Mijatovic.;David Ibberson.;Karam T AlHalabi.;Jenny Hetzer.;Simon Anders.;Bernhard Brüne.;Henrik E Mei.;Charles D Imbusch.;Benedikt Brors.;Mathias Heikenwälder.;Matthias M Gaida.;Markus W Büchler.;Andreas Weigert.;Thilo Hackert.;Susanne Roth.
来源: Gastroenterology. 2023年165卷4期891-908.e14页
As pancreatic ductal adenocarcinoma (PDAC) continues to be recalcitrant to therapeutic interventions, including poor response to immunotherapy, albeit effective in other solid malignancies, a more nuanced understanding of the immune microenvironment in PDAC is urgently needed. We aimed to unveil a detailed view of the immune micromilieu in PDAC using a spatially resolved multimodal single-cell approach.
3593. Amphipathic Liponecrosis Impairs Bacterial Clearance and Causes Infection During Sterile Inflammation.
作者: Sergiy Kostenko.;Biswajit Khatua.;Shubham Trivedi.;Anoop Narayana Pillai.;Bryce McFayden.;Mahmoud Morsy.;Prasad Rajalingamgari.;Vijeta Sharma.;Pawan Noel.;Krutika Patel.;Bara El-Kurdi.;Henrique Borges da Silva.;Xianfeng Chen.;Vishal Chandan.;Sarah Navina.;Stacie Vela.;Rodrigo Cartin-Ceba.;Christine Snozek.;Vijay P Singh.
来源: Gastroenterology. 2023年165卷4期999-1015页
Although transient bacteremia is common during dental and endoscopic procedures, infections developing during sterile diseases like acute pancreatitis (AP) can have grave consequences. We examined how impaired bacterial clearance may cause this transition.
3594. Key Genetic Determinants Driving Esophageal Squamous Cell Carcinoma Initiation and Immune Evasion.
作者: Kyung-Pil Ko.;Yuanjian Huang.;Shengzhe Zhang.;Gengyi Zou.;Bongjun Kim.;Jie Zhang.;Sohee Jun.;Cecilia Martin.;Karen J Dunbar.;Gizem Efe.;Anil K Rustgi.;Hiroshi Nakagawa.;Jae-Il Park.
来源: Gastroenterology. 2023年165卷3期613-628.e20页
Despite recent progress in identifying aberrant genetic and epigenetic alterations in esophageal squamous cell carcinoma (ESCC), the mechanism of ESCC initiation remains unknown.
3595. Risk stratification for predicting postoperative recurrence of gastric cancer by grade of venous invasion.
Venous invasion (VI) in pathological examination of surgically resected gastric cancer (GC) may predict postoperative recurrence, but there are no objective criteria for VI grading.
3596. Lower ultra-short-term heart rate variability can predict worse mucosal healing in ulcerative colitis.
作者: Jianan Guo.;Wenguo Chen.;Huatuo Zhu.;Hongtan Chen.;Xiaodong Teng.;Guoqiang Xu.
来源: BMC Gastroenterol. 2023年23卷1期188页
Psychological stress has been proved to be a risk factor for exacerbation for ulcerative colitis (UC). However, traditional approaches of quantifying psychological stress using psychological scales are time-consuming and the results may not be comparable among patients with different educational levels and cultural backgrounds. Alternatively, heart rate variability (HRV) is an indicator for psychological stress and not biased by educational and cultural backgrounds.
3597. Nucleolar HEAT Repeat Containing 1 Up-regulated by the Mechanistic Target of Rapamycin Complex 1 Signaling Promotes Hepatocellular Carcinoma Growth by Dominating Ribosome Biogenesis and Proteome Homeostasis.
作者: Xiao-Mei Yang.;Xiao-Qi Wang.;Li-Peng Hu.;Ming-Xuan Feng.;Yao-Qi Zhou.;Dong-Xue Li.;Jun Li.;Xiao-Cao Miao.;Yan-Li Zhang.;Lin-Li Yao.;Hui-Zhen Nie.;Shan Huang.;Qiang Xia.;Xue-Li Zhang.;Shu-Heng Jiang.;Zhi-Gang Zhang.
来源: Gastroenterology. 2023年165卷3期629-646页
Hyperactivation of ribosome biogenesis leads to hepatocyte transformation and plays pivotal roles in hepatocellular carcinoma (HCC) development. We aimed to identify critical ribosome biogenesis proteins that are overexpressed and crucial in HCC progression.
3599. Detailed Characteristics of Post-discharge Mortality in Acute Pancreatitis.
作者: Dóra Czapári.;Alex Váradi.;Nelli Farkas.;Gergely Nyári.;Katalin Márta.;Szilárd Váncsa.;Rita Nagy.;Brigitta Teutsch.;Stefania Bunduc.;Bálint Erőss.;László Czakó.;Áron Vincze.;Ferenc Izbéki.;Mária Papp.;Béla Merkely.;Andrea Szentesi.;Péter Hegyi.; .
来源: Gastroenterology. 2023年165卷3期682-695页
The in-hospital survival of patients suffering from acute pancreatitis (AP) is 95% to 98%. However, there is growing evidence that patients discharged after AP may be at risk of serious morbidity and mortality. Here, we aimed to investigate the risk, causes, and predictors of the most severe consequence of the post-AP period: mortality.
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