3556. Once-weekly insulin icodec versus once-daily insulin degludec as part of a basal-bolus regimen in individuals with type 1 diabetes (ONWARDS 6): a phase 3a, randomised, open-label, treat-to-target trial.
作者: David Russell-Jones.;Tetsuya Babazono.;Roman Cailleteau.;Susanne Engberg.;Concetta Irace.;Maiken Ina Siegismund Kjaersgaard.;Chantal Mathieu.;Julio Rosenstock.;Vincent Woo.;David C Klonoff.
来源: Lancet. 2023年402卷10413期1636-1647页
ONWARDS 6 compared the efficacy and safety of once-weekly subcutaneous insulin icodec (icodec) and once-daily insulin degludec (degludec) in adults with type 1 diabetes.
3559. Moving cholera vaccines ahead of the epidemic curve.
作者: Ziad A Memish.;Lucille Blumberg.;Amal Saif Al-Maani.;Rama Baru.;Eve Dube.;George F Gao.;Daniel B Jernigan.;Yee-Sin Leo.;Joseph Sriyal Malik Peiris.;Jakir Hossain B Masud.;Jodie McVernon.;Justice Nonvignon.;Folasade Tolulope Ogunsola.;Helen Reese.;Rana Muhammad Safdar.;Kumnuan Ungchusak.;Lothar H Wieler.;David Heymann.
来源: Lancet. 2024年403卷10422期127-129页 3560. Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial.
作者: Alexander C Ford.;Alexandra Wright-Hughes.;Sarah L Alderson.;Pei-Loo Ow.;Matthew J Ridd.;Robbie Foy.;Gina Bianco.;Felicity L Bishop.;Matthew Chaddock.;Heather Cook.;Deborah Cooper.;Catherine Fernandez.;Elspeth A Guthrie.;Suzanne Hartley.;Amy Herbert.;Daniel Howdon.;Delia P Muir.;Taposhi Nath.;Sonia Newman.;Thomas Smith.;Christopher A Taylor.;Emma J Teasdale.;Ruth Thornton.;Amanda J Farrin.;Hazel A Everitt.; .
来源: Lancet. 2023年402卷10414期1773-1785页
Most patients with irritable bowel syndrome (IBS) are managed in primary care. When first-line therapies for IBS are ineffective, the UK National Institute for Health and Care Excellence guideline suggests considering low- dose tricyclic antidepressants as second-line treatment, but their effectiveness in primary care is unknown, and they are infrequently prescribed in this setting.
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