3334. Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis.
作者: Hagit Baris Feldman.;Chofit Chai Gadot.;David Zahler.;Adi Mory.;Galit Aviram.;Emil Elhanan.;Gabi Shefer.;Ilana Goldiner.;Yam Amir.;Alina Kurolap.;Jacob N Ablin.
来源: N Engl J Med. 2023年389卷18期1685-1692页
Two siblings presented with cardiomyopathy, hypertension, arrhythmia, and fibrosis of the left atrium. Each had a homozygous null variant in CORIN, the gene encoding atrial natriuretic peptide (ANP)-converting enzyme. A plasma sample obtained from one of the siblings had no detectable levels of corin or N-terminal pro-ANP but had elevated levels of B-type natriuretic peptide (BNP) and one of the two protein markers of fibrosis that we tested. These and other findings support the hypothesis that BNP cannot fully compensate for a lack of activation of the ANP pathway and that corin is critical to normal ANP activity, left atrial function, and cardiovascular homeostasis.
3335. Thalidomide for Recurrent Bleeding Due to Small-Intestinal Angiodysplasia.
作者: Huimin Chen.;Shan Wu.;Mingyu Tang.;Ran Zhao.;Qingwei Zhang.;Zihao Dai.;Yunjie Gao.;Shiming Yang.;Zhaoshen Li.;Yiqi Du.;Aiming Yang.;Liang Zhong.;Lungen Lu.;Leiming Xu.;Xizhong Shen.;Side Liu.;Jie Zhong.;Xiaobo Li.;Hong Lu.;Hua Xiong.;Yufeng Shen.;Haiying Chen.;Shuai Gong.;Hanbing Xue.;Zhizheng Ge.
来源: N Engl J Med. 2023年389卷18期1649-1659页
Recurrent bleeding from the small intestine accounts for 5 to 10% of cases of gastrointestinal bleeding and remains a therapeutic challenge. Thalidomide has been evaluated for the treatment of recurrent bleeding due to small-intestinal angiodysplasia (SIA), but confirmatory trials are lacking.
3336. Reducing Harm - Having Conversations about Firearm Storage.
作者: Ruth Abaya.;Emmy Betz.;Carl Kincaid.;Sandra McKay.;Chana A Sacks.;Joseph Shahoud.;Tahmir L Suters.;Darren Taichman.;Kendra Van de Water.;Rayquan Williams.
来源: N Engl J Med. 2023年389卷18期e36页 |