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3281. COVID-19 vaccine safety during pregnancy and breastfeeding in women with autoimmune diseases: results from the COVAD study.
作者: Laura Andreoli.;Daniele Lini.;Karen Schreiber.;Ioannis Parodis.;Parikshit Sen.;Naveen Ravichandran.;Jessica Day.;Mrudula Joshi.;Kshitij Jagtap.;Arvind Nune.;Elena Nikiphorou.;Vishwesh Agarwal.;Sreoshy Saha.;Ai Lyn Tan.;Samuel Katsuyuki Shinjo.;Nelly Ziade.;Tsvetelina Velikova.;Marcin Milchert.;Abraham Edgar Gracia-Ramos.;Lorenzo Cavagna.;Masataka Kuwana.;Johannes Knitza.;Ashima Makol.;Aarat Patel.;John D Pauling.;Chris Wincup.;Bhupen Barman.;Erick Adrian Zamora Tehozol.;Jorge Rojas Serrano.;Ignacio García De La Torre.;Iris J Colunga-Pedraza.;Javier Merayo-Chalico.;Okwara Celestine Chibuzo.;Wanruchada Katchamart.;Phonpen Akarawatcharangura Goo.;Russka Shumnalieva.;Yi-Ming Chen.;Leonardo Santos Hoff.;Lina El Kibbi.;Hussein Halabi.;Binit Vaidya.;Syahrul Sazliyana Shaharir.;A T M Tanveer Hasan.;Dzifa Dey.;Carlos Enrique Toro Gutiérrez.;Carlo V Caballero-Uribe.;James B Lilleker.;Babur Salim.;Tamer Gheita.;Tulika Chatterjee.;Miguel A Saavedra.;Oliver Distler.;Hector Chinoy.;Vikas Agarwal.;Rohit Aggarwal.;Latika Gupta.; .
来源: Rheumatology (Oxford). 2024年63卷5期1341-1351页
We investigated coronavirus disease 2019 (COVID-19) vaccine safety in pregnant and breastfeeding women with autoimmune diseases (AID) in the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study.
3282. Development and testing of a bespoke cultural intervention to support healthcare professionals with patients from a diverse background.
作者: Ashwini Deshmukh.;Lisa Roberts.;Adewale Adebajo.;Atiya Kamal.;Christopher J Armitage.;Felicity Evison.;Helen Bunting.;Shirish Dubey.;Arumugam Moorthy.;Joti Reehal.;Nisha Dogra.;Kanta Kumar.
来源: Rheumatology (Oxford). 2024年63卷5期1352-1358页
Development and test of a culturally sensitive intervention for rheumatology healthcare professionals (HCPs).
3284. Apical fibrobullous lung disease in spondyloarthritis patients with biologic DMARDs indication.
作者: Zehra Ozsoy.;Gizem Ayan.;Gamze Durhan.;Umut Kalyoncu.
来源: Rheumatology (Oxford). 2024年63卷4期1147-1152页
The rate of pleuroparenchymal involvement in patients with SpA varies widely, from 0% to 85%. The most common form is apical fibrobullous disease (AFLD). The aim of this study was to determine the incidence of AFLD and associated factors in SpA patients under and/or planned to start biologic DMARDs (bDMARDs) therapy.
3285. Incidence of and risk factors for myelodysplastic syndrome in patients with rheumatologic diseases.
作者: Young-Eun Kim.;Soo Min Ahn.;Ji Seon Oh.;Seokchan Hong.;Chang-Keun Lee.;Bin Yoo.;Yong-Gil Kim.
来源: Rheumatology (Oxford). 2024年63卷5期1305-1312页
We investigated the incidence of and risk factors for myelodysplastic syndrome (MDS) in patients with rheumatologic disease.
3287. Occurrence and outcome of COVID-19 in AIRD patients on concomitant treatment with Tofacitinib- results from KRA COVID COHORT (KRACC) subset.
作者: Pramod Chebbi.;Vineeta Shobha.;Vijay K Rao.;Vikram Haridas.;Ramya Janardana.;Benzeeta Pinto.;Sharath Kumar.;Abhishek Patil.;Roopa Tekkatte.;Manasa Salanke.;K M Mahendranath.
来源: BMC Rheumatol. 2023年7卷1期22页
We assessed the risk factors and outcome of COVID-19 in patients with autoimmune rheumatic diseases(AIRD) who contracted infection while on background treatment with tofacitinib.
3288. Insights into juvenile myositis via engineered muscle.
The pathogenesis of juvenile dermatomyositis (JDM) is complex and various evidence implicate a role for type I interferons. Could the use of a bioengineered paediatric skeletal muscle model provide insight into this disease and have potential for high throughput testing of therapeutic agents?
3289. Prevalence and identification of neuropsychiatric symptoms in systemic autoimmune rheumatic diseases: an international mixed methods study.
作者: Melanie Sloan.;Chris Wincup.;Rupert Harwood.;Thomas A Pollak.;Efhalia Massou.;Michael Bosley.;Mervi Pitkanen.;Michael S Zandi.;Guy Leschziner.;Colette Barrere.;Mandeep Ubhi.;Laura Andreoli.;James Brimicombe.;Wendy Diment.;David Jayne.;Caroline Gordon.;Felix Naughton.;David D'Cruz.
来源: Rheumatology (Oxford). 2024年63卷5期1259-1272页
A limited range of neuropsychiatric symptoms have been reported in systemic autoimmune rheumatic diseases (SARDs), with varied symptom prevalence. This study aimed to investigate a wider range of potential symptoms than previous studies, compare patient self-reports with clinician estimates, and explore barriers to symptom identification.
3290. Divergence of patient-reported xerostomia and oral health in primary Sjögren's syndrome and the possible role of hydroxychloroquine.
作者: Alessia Alunno.;Francesco Carubbi.;Francesco Maria Mariani.;Jacopo Cipollone.;Michele Rossi.;Claudio Ferri.
来源: Rheumatology (Oxford). 2024年63卷2期e34-e36页 3291. Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis.
Sleep has a homeostatic role in the regulation of the immune system and serves to constrain activation of inflammatory signalling and expression of cellular inflammation. In patients with rheumatoid arthritis (RA), a misaligned inflammatory profile induces a dysregulation of sleep-wake activity, which leads to excessive inflammation and the induction of increased sensitivity to pain. Given that multiple biological mechanisms contribute to sleep disturbances (such as insomnia), and that the central nervous system communicates with the innate immune system via neuroendocrine and neural effector pathways, potential exists to develop prevention opportunities to mitigate the risk of insomnia in RA. Furthermore, understanding these risk mechanisms might inform additional insomnia treatment strategies directed towards steering and reducing the magnitude of the inflammatory response, which together could influence outcomes of pain and disease activity in RA.
3292. IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration.
IL-17 signalling regulates both protective and harmful immune responses; therefore, its complete inhibition can have adverse effects. Detailed consideration and fine-tuning of IL-17-inhibition strategies is needed to selectively regulate disease outcomes.
3293. Synovial and serum B cell signature of autoantibody-negative rheumatoid arthritis vs autoantibody-positive rheumatoid arthritis and psoriatic arthritis.
作者: Ludovico De Stefano.;Serena Bugatti.;Iolanda Mazzucchelli.;Silvia Rossi.;Blerina Xoxi.;Emanuele Bozzalla Cassione.;Terenzj Luvaro.;Carlomaurizio Montecucco.;Antonio Manzo.
来源: Rheumatology (Oxford). 2024年63卷5期1322-1331页
Autoantibody-negative RA differs from autoantibody-positive RA in several clinical aspects, possibly underpinned by pathogenetic differences. At present, the role of adaptive immune responses in autoantibody-negative RA remains unclear. Here, we investigated the synovial and serum immunophenotype indicative of B lymphocyte involvement across the spectrum of autoantibody-positive and -negative chronic arthritides.
3294. Pyrin variant E148Q potentiates inflammasome activation and the effect of pathogenic mutations in cis.
作者: Thomas Reygaerts.;Pawat Laohamonthonkul.;Katja Hrovat-Schaale.;Fiona Moghaddas.;Paul J Baker.;Paul E Gray.;Seth L Masters.
来源: Rheumatology (Oxford). 2024年63卷3期882-890页
The p.E148Q variant in pyrin is present in different populations at a frequency of up to 29%, and has been associated with diseases, including vasculitis and FMF. The pathogenicity of p.E148Q in FMF is unclear, even when observed in cis or in trans to a single, typically recessive, pathogenic mutation. We performed functional validation to determine whether p.E148Q increases the ability of pyrin to form an active inflammasome complex in cell lines.
3295. Construct validity and reliability of the Assessment of Systemic Sclerosis-Associated Raynaud's Phenomenon (ASRAP) questionnaire.
作者: John D Pauling.;Lan Yu.;Tracy M Frech.;Ariane L Herrick.;Laura K Hummers.;Ami A Shah.;Christopher P Denton.;Lesley Ann Saketkoo.;Jane Withey.;Dinesh Khanna.;Robyn T Domsic.
来源: Rheumatology (Oxford). 2024年63卷5期1281-1290页
Assessment of construct validity and reliability of a novel patient-reported outcome (PRO) instrument for assessing the severity and impact of RP in SSc.
3296. Increased risk of cardiovascular disease preceding diagnosis of incident ANCA-associated vasculitis: a Danish nationwide study.
作者: Louis Nygaard.;Christoffer Polcwiartek.;Karl Emil Nelveg-Kristensen.;Nicholas Carlson.;Salome Kristensen.;Christian Torp-Pedersen.; .;Jon Waarst Gregersen.
来源: Rheumatology (Oxford). 2024年63卷5期1313-1321页
To examine whether patients with ANCA-associated vasculitis (AAV) have an increased risk of cardiovascular disease in the months prior to diagnosis of AAV.
3297. Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) and early-phase DISH across the lifespan of an American population.
作者: Dale E Fournier.;Andrew E Leung.;Michele C Battié.;Cheryle A Séguin.
来源: Rheumatology (Oxford). 2024年63卷4期1153-1161页
DISH is a common musculoskeletal disorder; however, the imaging features and disease continuum from early to advanced stages is poorly understood. The purpose of this study was to evaluate the prevalence of DISH and early-phase DISH in an American population and to assess the extent and pattern of ectopic mineralization across the thoracic spine.
3298. Sleep quality and clinical association with sleep disturbance in systemic sclerosis.
作者: Nonthaphorn Wongthawa.;Apichart So-Gnern.;Ajanee Mahakkanukrauh.;Siraphop Suwannaroj.;Chingching Foocharoen.
来源: BMC Rheumatol. 2023年7卷1期21页
Poor sleep quality is a common and potentially debilitating problem in systemic sclerosis (SSc). To date, no data clarifies the potential factors related to poor sleep quality and the clinical associations with sleep disturbance among Thais with SSc-mainly the diffuse cutaneous SSc (dcSSc) subset. We aimed to evaluate sleep quality and identify the clinical association with sleep disturbance among SSc patients.
3299. Prognostic significance of pericardial effusion in systemic sclerosis-associated pulmonary hypertension: analysis from the PHAROS Registry.
作者: Yiming Luo.;Jessica K Gordon.;Jiehui Xu.;Kathleen D Kolstad.;Lorinda Chung.;Virginia D Steen.;Elana J Bernstein.; .
来源: Rheumatology (Oxford). 2024年63卷5期1251-1258页
Pulmonary hypertension (PH) is a leading cause of death in patients with SSc. The purpose of this study was to determine the prognostic significance of pericardial effusion in patients with SSc-PH.
3300. Whole exome sequencing of a German sarcoidosis family with four affected and one spontaneous remission case.
作者: Peter Kvacskay.;Thomas El Jammal.;Hanns-Martin Lorenz.;Yves Pacheco.;Alain Calender.
来源: Rheumatology (Oxford). 2024年63卷6期1512-1517页
To analyse genetic mechanisms triggering familial sarcoidosis, whole exome screening of a family of six persons with four cases of sarcoidosis and two healthy controls was performed integrating progressive and spontaneous remission cases and evaluating involved genetic alterations that could potentially determine the individual course of the disease.
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