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3084. Endovascular thrombectomy plus medical care versus medical care alone for large ischaemic stroke: 1-year outcomes of the SELECT2 trial.
作者: Amrou Sarraj.;Michael G Abraham.;Ameer E Hassan.;Spiros Blackburn.;Scott E Kasner.;Santiago Ortega-Gutierrez.;Muhammad Shazam Hussain.;Michael Chen.;Hannah Johns.;Leonid Churilov.;Deep K Pujara.;Faris Shaker.;Laith Maali.;Pere Cardona Portela.;Nabeel A Herial.;Daniel Gibson.;Osman Kozak.;Juan F Arenillas.;Bernard Yan.;Natalia Pérez de la Ossa.;Sophia Sundararajan.;Yin C Hu.;Dennis J Cordato.;Nathan W Manning.;Ricardo A Hanel.;Amin N Aghaebrahim.;Ronald F Budzik.;William J Hicks.;Jordi Blasco.;Teddy Y Wu.;Jenny P Tsai.;Joanna D Schaafsma.;Chirag D Gandhi.;Fawaz Al-Mufti.;Navdeep Sangha.;Steven Warach.;Timothy J Kleinig.;Vignan Yogendrakumar.;Felix Ng.;Edgar A Samaniego.;Mohammad A Abdulrazzak.;Mark W Parsons.;Mohammad H Rahbar.;Thanh N Nguyen.;Johanna T Fifi.;Vitor Mendes Pereira.;Maarten G Lansberg.;Greg W Albers.;Anthony J Furlan.;Pascal Jabbour.;Clark W Sitton.;Cathy Sila.;Nicholas Bambakidis.;Stephen M Davis.;Lawrence Wechsler.;Michael D Hill.;James C Grotta.;Marc Ribo.;Bruce C V Campbell.; .
来源: Lancet. 2024年403卷10428期731-740页
Multiple randomised trials have shown efficacy and safety of endovascular thrombectomy in patients with large ischaemic stroke. The aim of this study was to evaluate long-term (ie, at 1 year) evidence of benefit of thrombectomy for these patients.
3086. Repeat placental growth factor-based testing in women with suspected preterm pre-eclampsia (PARROT-2): a multicentre, parallel-group, superiority, randomised controlled trial.
作者: Alice Hurrell.;Louise Webster.;Jenie Sparkes.;Cheryl Battersby.;Anna Brockbank.;Katherine Clark.;Kate E Duhig.;Carolyn Gill.;Marcus Green.;Rachael M Hunter.;Paul T Seed.;Zoe Vowles.;Jenny Myers.;Andrew H Shennan.;Lucy C Chappell.; .
来源: Lancet. 2024年403卷10427期619-631页
Placental growth factor (PlGF)-based testing has high diagnostic accuracy for predicting pre-eclampsia needing delivery, significantly reducing time to diagnosis and severe maternal adverse outcomes. The clinical benefit of repeat PlGF-based testing is unclear. We aimed to determine whether repeat PlGF-based testing (using a clinical management algorithm and nationally recommended thresholds) reduces adverse perinatal outcomes in pregnant individuals with suspected preterm pre-eclampsia.
3087. Racial inequities in homicide rates and homicide methods among Black and White women aged 25-44 years in the USA, 1999-2020: a cross-sectional time series study.
In the USA, Black women aged 25-44 years are disproportionately murdered compared with their White counterparts. Despite ongoing efforts to reduce racial and structural inequities, the result of these efforts remains unclear, particularly in light of the COVID-19 pandemic.
3088. Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double-dummy, phase 3, non-inferiority trials.
作者: Florian Wagenlehner.;Caroline R Perry.;Thomas M Hooton.;Nicole E Scangarella-Oman.;Helen Millns.;Marcy Powell.;Emily Jarvis.;Jeremy Dennison.;Amanda Sheets.;Deborah Butler.;John Breton.;Salim Janmohamed.
来源: Lancet. 2024年403卷10428期741-755页
Gepotidacin is a novel, bactericidal, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by a distinct mechanism of action and a unique binding site, providing well balanced inhibition of two type II topoisomerase enzymes. Oral gepotidacin is under investigation to treat uncomplicated urinary tract infections. We aimed to compare the efficacy and safety of oral gepotidacin with that of nitrofurantoin in adolescent and adult female individuals with uncomplicated urinary tract infections.
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