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281. Work-related physical strain as novel risk factor for the severity of joint inflammation at diagnosis of anti-citrullinated protein antibodies-positive rheumatoid arthritis.
作者: Dennis A Ton.;Bastiaan T van Dijk.;Hanna W van Steenbergen.;Annette H M van der Helm-van Mil.
来源: Rheumatology (Oxford). 2026年65卷2期
Increased work-related physical strain associates with higher subclinical joint inflammation in the RA at-risk phase of clinically suspect arthralgia and with progression to RA. Based on this, we hypothesized that work-related physical strain is also associated with the severity of joint inflammation at RA diagnosis. We studied this in ACPA-positive and ACPA-negative RA separately, because of differences in aetiopathology.
282. Factors influencing vaccination decisions in patients with inflammatory rheumatic and musculoskeletal disease: a qualitative approach.
作者: Anastasia Suslow.;Romy Lauer.;Uta Kiltz.;Chantal Giehl.;Kerstin Hellwig.;Theresa Oganowski.;Thomas Grüter.;Maria Zacharopoulou.;Andreas Stallmach.;Anika Franz.;Ursula Marschall.;Joachim Saam.;Catharina Schumacher.;Stephanie Stock.;Dusan Simic.;Arim Shukri.;Kathrin Schlößler.;Ina Carola Otte.;Horst Christian Vollmar.; .
来源: BMC Rheumatol. 2026年10卷1期11页
Patients with inflammatory rheumatic and musculoskeletal diseases (iRMD) have an increased risk of infections due to immunosuppression and autoimmune disease. While vaccinations are an important preventive strategy, vaccination coverage remains insufficient in Germany. The study aimed to identify barriers and facilitators for vaccination uptake from the perspective of iRMD patients, general practitioners (GPs), and rheumatologists.
284. One mutation, divergent journeys: expanding the clinical spectrum of homozygous SAMHD1 deficiency in childhood.
作者: Hülya Ercan Emreol.;Dilara Ünal.;Deniz Nazire Cagdas Ayvaz.;Yelda Bilginer.;Seza Özen.
来源: Rheumatology (Oxford). 2026年65卷1期
Homozygous loss-of-function mutations in SAMHD1 classically cause Aicardi-Goutières syndrome type 5 (AGS5), characterized by neuroinflammation and intracranial calcifications. Increasing evidence suggests a broader clinical spectrum. We aimed to describe the phenotypic heterogeneity associated with a single homozygous SAMHD1 variant in paediatric patients and to highlight diagnostic and therapeutic implications.
290. Anti-mitochondrial M2 antibody links to cardiac involvement and immune-mediated inflammatory myopathy-like pathology in myositis.
作者: Yiyun Pang.;Lixi Zhang.;Chen Yao.;Shuang Zhou.;Jie Pang.;Lihua Duan.;Juan Meng.;Chen Yu.;Chanyuan Wu.;Chaojun Hu.;Jinzhi Lai.;Yanhong Wang.;Mingwei Tang.;Lin Qiao.;Dong Xu.;Jiuliang Zhao.;Xiaofeng Zeng.;Zhuang Tian.;Mengtao Li.;Qian Wang.
来源: Rheumatology (Oxford). 2026年65卷1期
Cardiac involvement in idiopathic inflammatory myopathies (IIM) is rare but potentially severe. Anti-mitochondrial M2 antibody (AMA-M2) has been implicated in cardiac involvement, but the association remains underexplored. This study aims to evaluate the clinical, pathological and prognostic features of AMA-M2 IIM.
291. Rheumatoid Arthritis referral criteria: systematic review of the literature.
作者: João Madruga Dias.;Raquel Ribeiro.;Teresa Costa.;Sofia Silvério Serra.;Sónia Silva.;Annamaria Iagnocco.;Helena Canhão.;Fernando Pimentel-Santos.
来源: BMC Rheumatol. 2026年10卷1期8页
Timely referral in Rheumatoid Arthritis (RA) is critical for early diagnosis and initiation of treatment, which are crucial to improve patient outcomes and limit radiographic progression. Optimized referral criteria, whether applied by clinicians or healthcare artificial intelligence systems, can facilitate faster and more accurate decisions regarding patient assessment by a Rheumatologist. Despite this need, a validated and widely adopted referral tool for RA is still lacking.
292. Add-on iguratimod or tacrolimus in methotrexate in patients with rheumatoid arthritis not achieving remission with methotrexate: a retrospective propensity score-matched study.
To evaluate the efficacy and safety of combination therapy with iguratimod (IGU) versus tacrolimus (TAC) plus methotrexate (MTX) in patients with rheumatoid arthritis (RA) who failed to achieve remission with MTX monotherapy.
294. Calibrated, explainable machine learning on routine laboratory data to characterize diagnostic assignment patterns in rheumatic diseases: a retrospective study of 12,085 patients.
作者: Amal Mohamed Elmesiry.;Amira Shahin Ibrahim.;Hemmat A Elabd.;Basma Mohamed El Naggar.;Eman E Abd Elsalam.;Mai Abd El Halim Moussa.;Eman A Rageh.;Mona Mokhtar.;Muhammad M Harb.;Aya H Elshazly.;Mohamed A Khalafallah.;Atef A Hassan.
来源: BMC Rheumatol. 2025年10卷1期10页
Overlap in routine laboratory profiles complicates differential diagnosis of rheumatic diseases, particularly seronegative spondyloarthritis. We examined whether models trained on routine labs reproduce diagnostic assignment patterns and yield calibrated, explainable probabilities.
296. Genetic susceptibility, walking activity and the risk of incident gout.
作者: Ziying Wu.;Ying Hu.;Yilun Wang.;Yuqing Zhang.;Hongyi He.;Chao Zeng.;Guanghua Lei.;Jie Wei.
来源: Rheumatology (Oxford). 2026年65卷2期
Genetic predisposition increases the risk of gout, while walking activity may reduce it. We evaluated whether genetic predisposition modifies the association between walking activity and gout risk.
298. Sex differences among patients with giant cell arteritis: insights from the Spanish ARTESER Registry.
作者: Delia Fernández-Lozano.;Marta Domínguez-Álvaro.;Javier Narváez.;Noemi Garrido-Puñal.;Eugenio de Miguel.;Paula V Estrada-Alarcon.;Iñigo Hernández-Rodríguez.;Maite Silva-Diaz.;Joaquín M Belzunegui.;Clara Moriano.;Julio Sánchez Martín.;Itziar Calvo.;Vicente Aldasoro.;Lydia Abasolo.;Javier Loricera.;Patricia Moya-Alvarado.;María J García-Villanueva.;Fernando Sánchez-Alonso.;Santos Castañeda.;José L Hernández.;Ricardo Blanco.; .
来源: Rheumatology (Oxford). 2026年65卷1期
To evaluate sex-based differences in clinical presentation, vascular phenotype, diagnostic approaches, treatment, adverse events and outcomes among patients with giant cell arteritis (GCA).
300. Polyarteritis nodosa associated with VEXAS syndrome and chronic myelomonocytic leukemia: a case-control study.
作者: Paul Cioni.;Yann Nguyen.;Julien Rohmer.;Valentin Lacombe.;Henry Dupuy.;Xavier Puéchal.;Gregory Pugnet.;Cécile-Audrey Durel.;Edoardo Conticini.;François Lifermann.;Philip Bielefeld.;Pierre Duffau.;Hartmut Mahrhofer.;Alexis Régent.;Ludovic Trefond.;Christian Agard.;Thomas Moulinet.;Perrine Smets.;Alice Bérezné.;Sophie Georgin-Lavialle.;Arsène Mekinian.;Benjamin Terrier.
来源: Rheumatology (Oxford). 2026年65卷2期
Polyarteritis nodosa (PAN) is a rare necrotizing vasculitis occurring alone or associated with other conditions, including VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome and chronic myelomonocytic leukaemia (CMML). We aimed to compare the presentation and outcomes of VEXAS- or CMML-associated PAN (VEXAS-PAN and CMML-PAN) with those of primary PAN.
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