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2541. Long-term colchicine for the prevention of vascular recurrent events in non-cardioembolic stroke (CONVINCE): a randomised controlled trial.
作者: Peter Kelly.;Robin Lemmens.;Christian Weimar.;Cathal Walsh.;Francisco Purroy.;Mark Barber.;Ronan Collins.;Simon Cronin.;Anna Czlonkowska.;Philippe Desfontaines.;Adinda De Pauw.;Nicholas Richard Evans.;Urs Fischer.;Catarina Fonseca.;John Forbes.;Michael D Hill.;Dalius Jatuzis.;Janika Kõrv.;Peter Kraft.;Christina Kruuse.;Catherine Lynch.;Dominick McCabe.;Robert Mikulik.;Sean Murphy.;Paul Nederkoorn.;Martin O'Donnell.;Peter Sandercock.;Bernadette Schroeder.;Gek Shim.;Katrina Tobin.;David J Williams.;Christopher Price.
来源: Lancet. 2024年404卷10448期125-133页
Anti-inflammatory therapy with long-term colchicine prevented vascular recurrence in coronary disease. Unlike coronary disease, which is typically caused by atherosclerosis, ischaemic stroke is caused by diverse mechanisms including atherosclerosis and small vessel disease or is frequently due to an unknown cause. We aimed to investigate the hypothesis that long-term colchicine would reduce recurrent events after ischaemic stroke.
2543. Burr-hole drainage with or without irrigation for chronic subdural haematoma (FINISH): a Finnish, nationwide, parallel-group, multicentre, randomised, controlled, non-inferiority trial.
作者: Rahul Raj.;Pihla Tommiska.;Timo Koivisto.;Ville Leinonen.;Nils Danner.;Jussi P Posti.;Dan Laukka.;Teemu Luoto.;Minna Rauhala.;Sami Tetri.;Tommi K Korhonen.;Jarno Satopää.;Riku Kivisaari.;Teemu Luostarinen.;Christoph Schwartz.;Tomasz Czuba.;Simo Taimela.;Kimmo Lönnrot.;Teppo L N Järvinen.; .
来源: Lancet. 2024年403卷10446期2798-2806页
Chronic subdural haematoma is a common surgically treated intracranial emergency. Burr-hole drainage surgery, to evacuate chronic subdural haematoma, involves three elements: creation of a burr hole for access, irrigation of the subdural space, and insertion of a subdural drain. Although the subdural drain has been established as beneficial, the therapeutic effect of subdural irrigation has not been addressed.
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