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1. Inflammatory and mucociliary dysfunction based endotypes across the spectrum of chronic airway diseases.
作者: Erin Cant.;Mathieu Bottier.;Morven Shuttleworth.;Jamie Stobo.;Lidia Perea.;Simon Finch.;Merete Long.;Hollian Richarson.;Daniela Alferes de Lima Headley.;Jeffrey T J Huang.;Amelia Shoemark.;James D Chalmers.
来源: Chest. 2025年
There is substantial overlap between features of COPD, asthma, bronchiectasis(BE) and cystic fibrosis(CF). Each is characterised by inflammation and mucociliary dysfunction.
2. Failure to report sex-specific risk factors in heart failure with preserved ejection fraction research: a scoping review.
作者: Kathryn A Drury.;Josie A Seeto.;Serena Hong.;Michael A Wewege.;Amanda D Hagstrom.
来源: Chest. 2025年
Despite research identifying clear sex-specific differences in the risk profile for heart failure with preserved ejection fraction (HFpEF), these risk factors are typically not reported in 'participant characteristics' of heart failure research. This leads to an incomplete understanding of how and why females are heavily predisposed to developing HFpEF.
3. Artificial Intelligence-Based Echocardiography in Pulmonary Arterial Hypertension.
作者: Bettia Celestin.;Shadi P Bagherzadeh.;Everton Santana.;Matthew Frost.;Mathias Iversen.;Frida N Hermansson.;Andrew Sweatt.;Roham T Zamanian.;Yoran M Hummel.;Gabriela Gomez Rendon.;Joseph Yen.;Marinella Sandros.;Michael Salerno.;Francois Haddad.
来源: Chest. 2025年
Echocardiography is central when assessing pulmonary hypertension (PH), but manual interpretation can be time-consuming and prone to error.
5. Hypoxic Burden is Associated with Cardiovascular Events: A Risk Stratification Analysis of the RICCADSA Cohort.
作者: Yüksel Peker.;Yeliz Celik.;Andrey Zinchuk.;Scott A Sands.;Susan Redline.;Ali Azarbarzin.
来源: Chest. 2025年
The Apnea-Hypopnea Index (AHI), the standard measure of obstructive sleep apnea (OSA), has limitations in reflecting disease severity.
6. Contemporary Trends in Pediatric Extubation Failure and Non-Invasive Respiratory Support Use.
作者: Jeremy M Loberger.;Mitchell Moore.;Matthew Scanlon.;Robinder G Khemani.;Samer Abu-Sultaneh.;Colin M Rogerson.
来源: Chest. 2025年
Prolonged invasive mechanical ventilation is associated with morbidity and mortality in children. Timely extubation is essential and must balance the competing risks of extubation failure (EF) and prolonged use of post-extubation non-invasive respiratory support.
7. Geographical Distribution of Phase II/III Pharmaceutical Randomised Controlled Trials in Adults with Interstitial Lung Disease.
作者: Mingkun Guan.;Emma Marshall.;Sadhana Sughesh.;Hong Ye.;Christopher J Ryerson.;Yet H Khor.
来源: Chest. 2025年
Pharmaceutical randomised controlled trials (RCTs) are critical for advancing treatments in interstitial lung disease (ILD). We evaluated global distribution of pharmaceutical RCTs of ILD and their associations with country-specific features.
8. Association between Hospital Safety-Net Status and Delivery of Rehabilitation to Older Adults with Acute Respiratory Failure.
作者: Jose Victor Jimenez.;Lingxiao Zhang.;Zhenqiu Lin.;Lauren E Ferrante.;Jason R Falvey.;Allan J Walkey.;Harlan M Krumholz.;Snigdha Jain.
来源: Chest. 2025年
Older adults with socioeconomic disadvantage suffer greater decline in function and cognition following critical illness, an adverse outcome potentially preventable through mobilization. Whether safety-net hospitals (SNHs) that serve the highest proportions of patients with socioeconomic disadvantage are less likely to deliver rehabilitation during hospitalization with stay in the intensive care unit (ICU) is unknown.
9. Mortality Outcomes and ACE Inhibitor Use in Patients with Idiopathic Pulmonary Fibrosis.
作者: Burcu Ozaltin.;Robert Chapman.;Tine Follet.;Marie Vermant.;Muhammad Qummer Ul Arfeen.;Natalie Fitzpatick.;Harry Hemingway.;Wim Wuyts.;Kenan Direk.;Joseph Jacob.
来源: Chest. 2025年
ACE inhibitors (ACEi) are widely used antihypertensive agents with proven cardioprotective effects. Previous mechanistic and clinical studies have suggested ACEi therapy may slow disease progression and reduce mortality in idiopathic pulmonary fibrosis (IPF).
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