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1. Does adjunctive endoscopic biliary drainage improve outcomes beyond glucocorticoids alone in IgG4-related pancreatobiliary disease?
作者: Zinan Zhang.;Yanbin Wei.;Jiafei Peng.;Yan Zhao.;Xin Yao.;Ye Zong.
来源: BMC Gastroenterol. 2025年25卷1期789页
Immunoglobulin G4 (IgG4)-related pancreatobiliary disease typically manifests as obstructive jaundice, complicating therapeutic choices. Glucocorticoids (GCs) are the primary treatment with many challenges, including high recurrence rates and patient tolerance variability. Endoscopic biliary drainage (EBD) is used to alleviate obstruction, but its role during treatment in IgG4-related pancreatobiliary disease is still contested. There remains a paucity of research comparing the potential benefits of combination therapy with GCs and EBD versus GCs monotherapy.
2. Ustekinumab enhances intestinal stenosis resolution by modulating fibrotic pathways in crohn's disease: a retrospective single-center study with translational analysis.
作者: Rieko Nakata.;Shuhei Hosomi.;Yumie Kobayashi.;Yu Nishida.;Hirotsugu Maruyama.;Masaki Ominami.;Yuji Nadatani.;Shusei Fukunaga.;Koji Otani.;Noriko Kamata.;Fumio Tanaka.;Tatsunari Fukuoka.;Kiyoshi Maeda.;Yasuhiro Fujiwara.
来源: BMC Gastroenterol. 2025年25卷1期785页
Few studies have evaluated the impact of biologic therapy on endoscopic findings and stenoses of small intestinal lesions in Crohn's disease (CD). This study aimed to compare the endoscopic effectiveness and stenotic changes induced by anti-tumor necrosis factor inhibitors (anti-TNF) and ustekinumab (UST) in patients with CD, along with histological and molecular comparisons of stenosis between the groups.
3. Effects of enhanced recovery after surgery nursing on patients undergoing laparoscopic colectomy: a systematic review and meta-analysis.
This study aimed to systematically evaluate the effects of Enhanced Recovery After Surgery (ERAS) nursing protocols on patients undergoing laparoscopic colectomy.
4. Gestational age-dependent clinical characteristics of necrotizing enterocolitis-associated intestinal perforation: a 10-year cohort study.
作者: Hong Wei.;Weihong Yue.;Gege Liu.;Feng Chen.;Xia Liu.;Ya Hu.
来源: BMC Gastroenterol. 2025年25卷1期787页
To delineate gestational age (GA)-dependent pathophysiology of necrotizing enterocolitis-associated intestinal perforation (NEC-IP) and establish precision management protocols.
5. Association between the blood urea nitrogen-albumin ratio and mortality in critically ill patients with gastrointestinal bleeding: a retrospective cohort study.
作者: Xingyi Yang.;Mengyuan Chen.;Mengyin Zhu.;Yiling Ying.;Lang Gao.;Lihong Lv.;Xiaoxiao Wang.;Xiangshu Yuan.
来源: BMC Gastroenterol. 2025年25卷1期786页
Acute gastrointestinal bleeding (GIB) represents a life-threatening medical emergency. This study investigates the prognostic utility of the Blood Urea Nitrogen-to-albumin ratio (BAR) in patients with GIB.
6. Linked color imaging for detection and characterization of gastrointestinal neuroendocrine tumors.
作者: Xin Pu.;Yang Xu.;Xueting Zhang.;Zijin Yin.;Yan Liu.;Min Min.
来源: BMC Gastroenterol. 2025年25卷1期784页
The endoscopic detection of gastrointestinal neuroendocrine tumors (GI-NETs) remains clinically challenging. Linked color imaging (LCI), which enhances color contrast, may improve the identification of tumorous lesions. This study aims to evaluate the endoscopic characteristics of GI-NETs using LCI in comparison with white light imaging (WLI).
7. Efficacy of N-Acetylcysteine in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and meta-analysis.
作者: Ahmad Hormati.;Asma Mousavi.;Shayan Shojaei.;Atie Moghtadaei.;Sanaz Bordbar.;Hediyeh Alemi.;Amir Kasaeian.;Sadaf Sepanlou.
来源: BMC Gastroenterol. 2025年25卷1期783页
Endoscopic retrograde cholangiopancreatography (ERCP) is a widely utilized procedure for diagnosing and treating biliary and pancreatic disorders. However, it carries a risk of post-ERCP pancreatitis (PEP). N-Acetylcysteine (NAC) has been proposed as a potential prophylactic agent due to its antioxidant properties, yet its efficacy remains debated. This systematic review and meta-analysis aimed to evaluate the effectiveness of NAC in preventing PEP in patients undergoing ERCP.
8. Autoimmune gastritis: clinical and histological study in a Peruvian population.
作者: Fernando Arevalo.;Soledad Rayme.;Romy Rolando.;Rocío Ramírez.;Grace Rodas.;Jaime Fustamante.;Eduardo Monge.;Pedro Montes.;Julio Maraví.
来源: BMC Gastroenterol. 2025年25卷1期780页
The diagnosis of autoimmune gastritis poses significant challenges, particularly in resource-limited settings where access to serological tests is restricted. This study aimed to evaluate the histological, endoscopic, and serological features of patients diagnosed with autoimmune gastritis in our population.
9. A novel model of dual-network composite hydrogels for application in endoscopic submucosal dissection.
作者: Fei Zhao.;YunFang Bai.;JunJie Wu.;ZhiHao Zhu.;JinLei Mao.;Aikebaier Aili.;HongRun Gu.;ShiJie Yu.;ZhiFei Wang.
来源: BMC Gastroenterol. 2025年25卷1期781页
Endoscopic submucosal dissection (ESD) is a critical technique for treating early-stage gastrointestinal tumors, requiring precise operational skills. Traditional training methods, however, face challenges such as high costs, ethical concerns, and sustainability issues. This study aims to design a novel training model based on dual-network composite hydrogel (DNH) (Jing, et al, Polymers 11:952,2019) to simulate the multilayered structure of gastric tissue, providing a more realistic and effective training environment.
10. Neutrophil percentage-to-albumin ratio for preoperative risk stratification of complicated appendicitis in children: a retrospective study.
Preoperative risk assessment of complicated appendicitis in children holds substantial clinical importance. This study aimed to evaluate the association between the neutrophil percentage-to-albumin ratio (NPAR) and the occurrence of complicated appendicitis in pediatric patients.
11. Analysis of exercise behavior and influencing factors in patients with inflammatory bowel disease during remission and mild disease activity.
作者: Yuan Xue.;Yajun Sun.;Jiajia Wu.;Bo Chen.;Jing Wang.;Bingqing Lu.
来源: BMC Gastroenterol. 2025年25卷1期779页
This study aimed to investigate the distribution of exercise stages and exercise preference among patients with Inflammatory Bowel Disease in remission or with mild disease activity and explore their influencing factors.
12. Low pillow height is associated with LPR among patients with GERD: a retrospective single-center study.
作者: Huiru Cao.;Hui Yin.;Linzhen Li.;Shaofeng Liu.;Xiaoping Niu.
来源: BMC Gastroenterol. 2025年25卷1期778页
Gastroesophageal reflux disease (GERD) combined with laryngo-pharyngeal reflux (LPR) has poor drug efficacy, which seriously affects their mental health and quality of life. Investigation of the risk factors and construct predictive models to improve preventive strategies.
13. Regulatory effects of miR-30c knockout on hepatic lipid metabolism and progression of liver fibrosis.
作者: Shasha Ma.;Minghui Yang.;Weiye Qiang.;Feng Zhou.;Zuo Chen.;Yu Gao.;Li Zhang.
来源: BMC Gastroenterol. 2025年25卷1期777页
Liver fibrosis is a chronic progressive liver disease influenced by environmental and genetic factors. Early stages of liver fibrosis are marked by abnormal fat deposition in the liver. MicroRNA-30c (miR-30c) plays key roles in various pathological processes, including lipid metabolism, metabolic disorders, and cancer. However, the precise role of miR-30c in the progression of liver fibrosis remains unclear. This study aimed to investigate the role of miR-30c in liver fibrosis using miR-30c knockout (KO) mice.
14. Risk prediction models for lymph node metastasis in early gastric cancer patients: a systematic review and meta-analysis.
作者: Meng Duan.;Min Li.;Lei He.;Shiming Dai.;Lang Zhou.;Zhiqun Liu.;Jie Yang.;Lingyuan Chen.;Xiang Liu.;Zhaoshu Wu.
来源: BMC Gastroenterol. 2025年25卷1期776页
The number of risk prediction models for lymph node metastasis in early gastric cancer is increasing, but the quality and applicability of these models in clinical practice and future research remain unknown.
15. Prevalence of gastric cancer and its associated mortality among patients undergoing upper gastrointestinal endoscopy at a tertiary level hospital in Tanzania.
Descriptive data on gastric cancer (GC) from African countries are limited. We describe the prevalence, clinicopathological features, short-term outcomes and factors associated with gastric cancer at Muhimbili National Hospital (MNH), which is a tertiary-level facility in Tanzania.
16. Endoscopic intervention for patients of renal insufficiency with upper gastrointestinal bleeding: efficacy evaluation and predictive model construction.
作者: Yongle Huang.;Qia Chen.;Rirong Chen.;Minhu Chen.;Xianwen Guo.;Zhen Ding.
来源: BMC Gastroenterol. 2025年25卷1期773页
To explore disease severity thresholds beyond which endoscopic intervention fails to reduce mortality in the context of renal insufficiency and upper gastrointestinal bleeding (UGIB), and to develop predictive models for mortality.
17. Establishment of normative spleen volume in a Japanese cohort using automated CT segmentation: diagnostic implications for liver fibrosis.
作者: Akio Tamura.;Kotaro Fujita.;Yoshiro Ieko.;Yuji Suzuki.;Ichinoshin Maki.;Kunihiro Yoshioka.
来源: BMC Gastroenterol. 2025年25卷1期775页
In this study, we aimed to establish specific reference values for spleen volume in Japan using automated deep learning-based segmentation as well as evaluate the diagnostic utility of volume-defined splenomegaly in staging liver fibrosis.
18. Histological remission as a reliable predictor of clinical outcomes in patients with ulcerative colitis after conventional therapy: a 5-year analysis.
作者: Tong Tu.;Xiaojun Zhuang.;Yun Qiu.;Manying Li.;Mengqi Chen.;Jianming Lin.;Zhirong Zeng.;Tong Li.
来源: BMC Gastroenterol. 2025年25卷1期771页
Histological remission has emerged as a promising target that may improve long-term outcomes in patients with ulcerative colitis (UC). The aim of this study was to investigate correlations between clinical, endoscopic, and histological remissions and the predictive value of histological remission on long-term outcomes in patients with UC receiving conventional therapy.
19. Early elevation of complement-related proteins in metabolic dysfunction-associated steatotic liver disease (MASLD) with normal liver enzymes.
作者: Li Shao.;Binbin Zhang.;Jing Liu.;Zhe Lyu.;Weishi Zhang.;Wenjun Yang.;Jinlong Fu.;Weijie Wu.;Xueqing Zhong.;Jie Li.;Junping Shi.
来源: BMC Gastroenterol. 2025年25卷1期772页
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects a quarter of the population. Although multiple studies have investigated the mechanisms underlying steatohepatitis and MASLD progression, little attention has been paid to milder cases, particularly those with normal enzyme levels. Our objective was to evaluate the molecular events in patients with MASLD and normal enzyme levels.
20. The prevalence of gallstone disease and associated factors among patients who visited the surgical department of Debre Birhan Comprehensive Specialized Hospital, Debre Birhan, Ethiopia: an institution-based cross-sectional study.
作者: Natnael Yikeber Hailesilassie.;Soressa Abebe Geneti.;Balkew Agonafir.
来源: BMC Gastroenterol. 2025年25卷1期767页
The gallstone disease is gradually becoming a burden of healthcare systems throughout world. The frequency of gallstone disease in Ethiopia has been the subject of few investigations and to the best of our knowledge, limited evidence of published research has examined the risk factors linked with gallstone disease. The main objective of the current study was to assess the prevalence of gallstone disease and associated factors among patients who visited the surgical department of Debre Birhan Comprehensive Specialization Hospital.
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