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1. Geographical variations in continuous positive airway pressure termination rates in patients with obstructive sleep apnea: insights from the ALASKA French nationwide dataset.
作者: Sébastien Bailly.;Guillaume Deltreil.;Florent Lavergne.;Renaud Tamisier.;Sébastien Baillieul.;Jean Louis Pépin.
来源: Chest. 2025年 2. Examining the threat of H5N1 highly pathogenic avian influenza to human health.
作者: Juliette Blais-Savoie.;Emily Halajian.;Kuganya Nirmalarajah.;Andra Banete.;Juan C Corredor.;Jonathon D Kotwa.;Yaejin Lee.;Sugandha Raj.;Shayan Sharif.;Nicole Mideo.;Samira Mubareka.
来源: Chest. 2025年 3. A National Evaluation of Intercostal Chest Drain Removal Strategies.
作者: Author List Niki Veale.;Anthony W Martinelli.;Dheeraj Sethi.;Phillip De Souza.;Khaing Zar Mon.;Joyce Oi Suet Cheng.;David Morrow.;May Sam.;Irfan Saleem.;Kay Por Yip.;Jennifer Kerks.;David E Henshall.;Tobias Smitherman-Cairns.;Katherine Smith.;Daniel Mitchell.;Karl Jackson.;Benjamin Pippard.;Seemab Paul.;Waheed Mohammad.;James Hyman.;Ben Rowlands.;Samantha Bosence.;Catharine Pearce.;Ben Probyn.;Richard Thorley.;Matthew Mitchell.;Andrew Griffiths.;Richard Westley.;Abdullah Huda.;Asim Mehmood.;Abid Khan.;Vern Tee.;Rachel Crooks.;Paul Minnis.;Lewis Standing.;Wei Hann Ong.;M Salman Rashid.;Ahmed Salih.;Eve Lynn Koh.;Ching Khai Ho.;Yiwen Soo.;Matthew Hayes.;Clodagh Holmes.;Fatima Al-Arrayed.;Abeer Saad.;Beenish Iqbal.;Sam Trewick.;Patrick Goodley.;Jonathan Oldershaw.;Elizabeth Thompson.;Alexandra Hodge.;Mohamed Gadallah.;Rahul Bhat.;Eleanor Barton.;Anand Sundaralingam.;Osei Kankam.;James Quinn.;John P Corcoran.;Steven P Walker.;Avinash Aujayeb.;Jurgen Herre.;Akhilesh Jha.;Stefan J Marciniak.;Najib M Rahman.;Rob J Hallifax.
来源: Chest. 2025年
Management of spontaneous pneumothorax often involves intercostal chest drain (ICD) insertion. Determining when to remove the ICD is controversial, with significant variation in practice. Establishing optimal ICD management in pneumothorax could reduce morbidity and improve cost effectiveness.
5. Impact of Elevated Pulmonary Arterial Wedge Pressure on Safety and Efficacy of Balloon Pulmonary Angioplasty in the Treatment of Chronic Thromboembolic Pulmonary Hypertension.
作者: Piotr Szwed.;Paweł Kurzyna.;Marta Banaszkiewicz-Cyganik.;Piotr Kędzierski.;Michał Łomiak.;Rafał Wolański.;Marcin Wasilewski.;Michał Florczyk.;Michał Piłka.;Adam Torbicki.;Marcin Kurzyna.;Szymon Darocha.
来源: Chest. 2025年
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare condition caused by thromboembolic occlusions of the pulmonary arteries and characterized by elevated pulmonary pressure, vascular remodelling, and right ventricular overload, which can be treated effectively with balloon pulmonary angioplasty (BPA). The study aimed to evaluate whether elevated pulmonary arterial wedge pressure (PAWP), associated with left ventricular dysfunction, influences the effectiveness and safety of BPA treatment.
6. Post-ICU Care Trajectories and Outcomes Among Veterans: Comparing VA and Community Hospital Discharges.
作者: Zachary Hahn.;Hiam Naiditch.;Martha F Brucato.;Victor Talisa.;Brian Tyler.;John R Hotchkiss.;Sachin Yende.;Bryan J McVerry.;Florian B Mayr.
来源: Chest. 2025年
Critical illness survivors face fragmented care transitions, leading to readmissions, emergency care use, and death. The Veterans Affairs Patient Aligned Care Team model emphasizes coordinated outpatient follow-up, yet many veterans now receive VA-purchased intensive care at community hospitals, potentially disrupting continuity.
7. Cardiovascular Events in COPD: Complementary Role of Cardiac Risk and Coronary Artery Calcium Scores.
作者: Juan P de-Torres.;Ciro Casanova.;Jorge Zagaceta.;José M Marín.;Carlos Cabrera.;Ana Ezponda.;Arantza Campo.;Ana Belén Alcaide.;Luis Seijo.;Gorka Bastarrika.;Victor Pinto-Plata.;Miguel Divo.;Bartolome R Celli.
来源: Chest. 2025年
Patients with COPD are at high risk of major adverse cardiovascular events (MACEs) developing. Existing clinical tools for risk stratification in these patients have underperformed in predicting the outcomes.
8. Hypoglossal Nerve Stimulation in the Context of non-Continuous Positive Airway Pressure Therapy in Patients with Obstructive Sleep Apnea: Improvement in the Apnea-Hypopnea Index in Randomized Controlled Trials.9. Post-Intensive Care Syndrome Awareness and Communication: Surveys of ICU Providers and Patients.
作者: Mark L Rolfsen.;Matthew F Mart.;Hannah Kieffer.;David Krasinski.;Timothy D Girard.;Lauren E Ferrante.;Robert L Owens.;Ana Lucia Fuentes.;Nathan Brummel.;Carla M Sevin.;John P Kress.;Jaspal Singh.;Sukhvinder Nagi.;Kevin Shaw.;Edward Qian.;James C Jackson.;Christopher G Hughes.;Pratik Pandharipande.;Mayur Patel.;Tom Elasy.;E Wesley Ely.
来源: Chest. 2025年
Survivors of critical illness often experience new or worsening impairments in various domains of health after discharge, collectively referred to as post-intensive care syndrome (PICS). Although this condition is common, it remains unclear whether providers are communicating routinely about survivorship and PICS to patients and families and whether patients are remembering these conversations.
10. Inspiratory Effort and Dynamic Transpulmonary Driving Pressure in Extremely Preterm Infants.
作者: Daniele De Luca.;Sofia De La Rubia.;Francesca Miselli.;Guillaume Emeriaud.;Barbara Loi.;Marco Piastra.;Giorgio Conti.;Massimo Antonelli.;Domenico Luca Grieco.
来源: Chest. 2025年
In preterm infants receiving noninvasive ventilation, data about inspiratory effort (ΔPes) and transpulmonary driving pressure (ΔPL) are scarce. Electrical activity of the diaphragm (EAdi) can estimate ΔPes and ΔPL when patient size precludes more accurate measurements. This estimation may reveal new insights into respiratory pathophysiology and potential risk of self-inflicted lung injury in neonates receiving noninvasive support.
11. Newly Onset Dyspnea During Pregnancy.
作者: Marie Vermant.;Valerie Van Ballaer.;Tine Follet.;Eveline Claeys.;Samuel De Bontridder.;Nico De Crem.;Adriana Dubbeldam.;Alexandros Kalkanis.;Laurens J De Sadeleer.;Ellen De Langhe.;Wim A Wuyts.
来源: Chest. 2025年168卷4期e115-e120页 12. Respiratory Dyskinesia With Refractory Tachypnea and Alkalosis Treated by Vesicular Monoamine Transporter 2 Inhibitor.
We present the case of a 69-year-old woman with a 25-year history of psychosis, managed with risperidone, who developed refractory tachypnea and alkalosis over 2 weeks. Despite multidisciplinary evaluation, she was initially misdiagnosed with psychogenic hyperventilation. Ultimately, a diagnosis of respiratory dyskinesia (RD) was established, and substantial clinical improvement was achieved after initiation of a vesicular monoamine transporter 2 (VMAT2) inhibitor. The substantial effectiveness of this therapy was confirmed over a 7-month follow-up period, with monitoring of both clinical symptoms and arterial blood gas parameters. This case highlights the diagnostic challenges posed by RD and underscores the potential utility of VMAT2 inhibitor as a novel therapeutic option.
13. A 44-Year-Old Man With a Solitary, Slowly Enlarging Mediastinal Lesion.
作者: Vasiliki Kolokotroni.;Garyfallia Perlepe.;Angeliki Cheva.;Christoforos Foroulis.;Konstantinos I Gourgoulianis.
来源: Chest. 2025年168卷4期e107-e110页
A 44-year-old man, who does not smoke, presented for investigation of a right mediastinum lesion as revealed on a routine radiograph that was performed as a requirement of his life insurance. The patient reported no associated symptoms. He did not report shortness of breath, cough, sputum, fever, chest pain, or hemoptysis. The remaining review of symptoms was also negative for issues such as muscle weakness, weight loss, night sweats, fatigue, skin rash, and visible, palpable, or painful lymphadenopathy. His medical history was unremarkable, and he did not receive any regular medication. The patient's professional occupation was not related to special exposure and he did not report alcohol consumption, illicit drug use, or any recent travel.
14. Differential Effects of Antifibrotic Treatment on Outcome Prediction via Serial Matrix Metalloproteinase-Degraded C-Reactive Protein Neoepitope Levels in Idiopathic Pulmonary Fibrosis.
作者: Benjamin Seeliger.;Jannik Ruwisch.;Jannie Marie Bülow Sand.;Filipa B Simões.;Henrik Jessen.;Eda Boerner.;Jan Fuge.;Katherina Sewald.;Tobias Welte.;Pedro David Wendel-Garcia.;Jonas C Schupp.;Diana Julie Leeming.;Francesco Bonella.;Antje Prasse.
来源: Chest. 2025年
Idiopathic pulmonary fibrosis (IPF) is characterized by an increase in proteolytic enzymes, including matrix metalloproteinases that degrade the extracellular matrix and markers of localized inflammation. Protein fragments (neoepitopes) are detectable in the circulation.
15. EMERGING TECHNOLOGY FOR NON-INVASIVELY MEASURING OXYGEN SATURATIONS.
Measurement of blood (SpO2) and tissue (StO2) oxygenation is routinely performed in clinical practice. Arterial Blood Gas (ABG) analysis, though considered as the gold standard for SpO2 estimation, requires arterial puncture, trained personnel and laboratory back up. Currently, there is a lack of universally accepted and widely used method for StO2 measurement. Available non-invasive methods for SpO2 and StO2 estimation have several limitations. Many technologies are under development to address this unmet clinical need.
16. International Stakeholder Engagement on Clinical Care and Research for Sleep Assessment and Nocturnal Hypoxemia in Pulmonary Fibrosis.
作者: Leona Dowman.;Shane Landry.;Natasha Smallwood.;Catharina Moor.;Bradley A Edwards.;Christopher J Ryerson.;Christine F McDonald.;Nicole S Goh.;Harry Patsamanis.;Lynne Cochrane.;Simon Joosten.;Marlies Wijsenbeek.;Magnus Ekström.;Sebastian V Moreno.;Graham Hepworth.;Anne E Holland.;Yet H Khor.
来源: Chest. 2025年
Nocturnal hypoxemia commonly affects people with pulmonary fibrosis (PF).
17. Positive Airway Pressure Therapy Use and Health Care Resource Use in Patients With OSA and Comorbid Insomnia.
作者: Kate V Cole.;Anita S Malik.;Peter A Cistulli.;Kimberly L Sterling.;Atul Malhotra.;Naomi Alpert.;Jean-Louis Pepin.; .
来源: Chest. 2025年
Insomnia and OSA, together known as comorbid insomnia and OSA (COMISA), are highly prevalent sleep disorders, each of which has the potential to impair treatment efficacy for the other.
18. Specialist Dietary Intervention in Patients With Fibrotic Interstitial Lung Disease Experiencing Unintentional Weight Loss: A Pilot Randomized Controlled Trial.
作者: Rasleen Kahai.;Gioele Castelli.;Fiammetta Danzo.;Luis Ferreira.;Arthihai Srirangan.;Matteo Morviducci.;Flavio Marco Mirabelli.;Punchalee Kaenmuang.;Cara Roberts.;Simon Bax.;Richard J Hewitt.;Maria Kokosi.;Felix Chua.;Vasileios Kouranos.;Philip L Molyneaux.;Peter M George.;Richard Gisli Jenkins.;Winston Banya.;Carmel J W Stock.;Steve Jones.;Gemma Korff.;Alastair Duncan.;Athol U Wells.;Piersante Sestini.;Elisabetta A Renzoni.
来源: Chest. 2025年
Weight loss in patients with fibrotic interstitial lung disease (F-ILD) is associated with poor prognosis, yet the impact of dietary input is unknown.
19. Acetazolamide Plus Atomoxetine for Obesity Hypoventilation Syndrome Treatment.
作者: Elisa Perger.;Gianfranco Parati.;Andrea Faini.;Laura Gell.;Paola Faverio.;Fabrizio Luppi.;Simona Bertoli.;Amelia Brunani.;Elisabetta Bigagli.;Carolina Lombardi.;Luigi Taranto-Montemurro.
来源: Chest. 2025年
A subgroup of patients with obesity exhibits hypoventilation as a result of, among other mechanisms, a narrow, collapsible upper airway (UA), a reduced ventilatory drive during both wakefulness and sleep, and the loss of pharyngeal muscle tone during sleep. These features characterize obesity-hypoventilation syndrome (OHS). If left untreated, OHS is associated with significant morbidity and mortality. Besides lifestyle modifications, positive airway pressure (PAP) is the only available treatment, and it is often not well tolerated. Drugs designed to activate UA muscles such as atomoxetine and to stimulate breathing such as acetazolamide represent a potential novel strategy for treating OHS.
20. The Impact of Dual Cannabis and Tobacco Smoking in Young Patients With Lung Cancer: Results From the Prospective "Environment and Lung Cancer" Study.
作者: Pauline Pradère.;A Marinello.;D Vasseur.;C Naltet.;S Moaca.;J Le Pavec.;M R Ghigna.;V De Montpreville.;J Adam.;L Lacroix.;F Ben Sallem.;C Caramella.;D Planchard.;O Mercier.;M Aldea.;J C Alvarez.
来源: Chest. 2025年
The role of cannabis smoking in lung cancer has long been underexplored due to its historical illegality and frequent co-use with tobacco. As cannabis use increases globally, particularly among younger individuals, understanding its impact on lung cancer is critical.
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