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1648. The Effect of Low-Dose Glucocorticoids Over Two Years on Weight and Blood Pressure in Rheumatoid Arthritis: Individual Patient Data From Five Randomized Trials.
作者: Andriko Palmowski.;Sabrina M Nielsen.;Zhivana Boyadzhieva.;Linda Hartman.;Judith Oldenkott.;Björn Svensson.;Ingiäld Hafström.;Siegfried Wassenberg.;Ernest Choy.;John Kirwan.;Robin Christensen.;Maarten Boers.;Frank Buttgereit.
来源: Ann Intern Med. 2023年176卷9期1181-1189页
Weight gain and hypertension are well known adverse effects of treatment with high-dose glucocorticoids.
1649. Social, Behavioral, and Metabolic Risk Factors and Racial Disparities in Cardiovascular Disease Mortality in U.S. Adults : An Observational Study.
作者: Jiang He.;Joshua D Bundy.;Siyi Geng.;Ling Tian.;Hua He.;Xingyan Li.;Keith C Ferdinand.;Amanda H Anderson.;Kirsten S Dorans.;Ramachandran S Vasan.;Katherine T Mills.;Jing Chen.
来源: Ann Intern Med. 2023年176卷9期1200-1208页
Cardiovascular disease (CVD) mortality is persistently higher in the Black population than in other racial and ethnic groups in the United States.
1653. Comparative Effectiveness and Safety of Generic Versus Brand-Name Fluticasone-Salmeterol to Treat Chronic Obstructive Pulmonary Disease.
作者: William B Feldman.;Aaron S Kesselheim.;Jerry Avorn.;Massimiliano Russo.;Shirley V Wang.
来源: Ann Intern Med. 2023年176卷8期1047-1056页
In 2019, the U.S. Food and Drug Administration (FDA) approved the first generic maintenance inhaler for asthma and chronic obstructive pulmonary disease (COPD). The inhaler, Wixela Inhub (fluticasone-salmeterol; Viatris), is a substitutable version of the dry powder inhaler Advair Diskus (fluticasone-salmeterol; GlaxoSmithKline). When approving complex generic products like inhalers, the FDA applies a special "weight-of-evidence" approach. In this case, manufacturers were required to perform a randomized controlled trial in patients with asthma but not COPD, although the product received approval for both indications.
1655. Fatal Drug Overdose Risks of Health Care Workers in the United States : A Population-Based Cohort Study.
作者: Mark Olfson.;Candace M Cosgrove.;Melanie M Wall.;Carlos Blanco.
来源: Ann Intern Med. 2023年176卷8期1081-1088页
Despite an unprecedented increase in drug overdose deaths in the United States, the risks faced by U.S. health care workers, who often have access to controlled prescription drugs, are not known.
1657. Estimating Breast Cancer Overdiagnosis After Screening Mammography Among Older Women in the United States.
作者: Ilana B Richman.;Jessica B Long.;Pamela R Soulos.;Shi-Yi Wang.;Cary P Gross.
来源: Ann Intern Med. 2023年176卷9期1172-1180页
Overdiagnosis is increasingly recognized as a harm of breast cancer screening, particularly for older women.
1659. How Would You Manage This Patient With Clostridioides difficile Infection? : Grand Rounds Discussion From Beth Israel Deaconess Medical Center.
作者: Zahir Kanjee.;Jessica R Allegretti.;Carolyn D Alonso.;Risa B Burns.
来源: Ann Intern Med. 2023年176卷8期1101-1108页
The Infectious Diseases Society of America/Society for Healthcare Epidemiology of America and the American College of Gastroenterology recently released updated guidelines on management of patients with Clostridioides difficile infection. Although these 2 guidelines generally agree, there are a few important differences in their advice to clinicians. In these rounds, 2 experts, an infectious diseases specialist and a gastroenterologist, discuss antibiotic treatment options for nonsevere disease, the role of fecal microbiota transplantation for fulminant disease, and the use of bezlotoxumab to prevent recurrence in the context of Ms. C, a 48-year-old woman with fulminant C difficile infection.
1660. Contraception.
作者: Rachel Cannon.;Kelly Treder.;Elisabeth J Woodhams.
来源: Ann Intern Med. 2023年176卷8期ITC113-ITC128页
Contraception counseling and provision are vital components of comprehensive health care. An unplanned pregnancy can be particularly challenging for patients with chronic illness. Internal medicine physicians are uniquely positioned to assess pregnancy readiness and provide contraception, as they often intersect with pregnancy-capable patients at the moment of a new diagnosis or when providing ongoing care for a chronic medical condition. A shared decision-making counseling approach engages patients, ensures patient-centered care, and supports their choice of a contraceptive method that aligns with their reproductive plans and medical needs.
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