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1601. Voxelotor as a Treatment of Persistent Hypoxia in the ICU.
Hypoxia is encountered frequently in the ICU as a result of a wide range of pathologic characteristics. The oxygen-hemoglobin dissociation curve describes hemoglobin's affinity for a given Po2 and factors affecting uptake and offload. Research in manipulating this relationship between hemoglobin and oxygen is sparing. Voxelotor is a hemoglobin oxygen-affinity modulator that is approved by the US Food and Drug Association for use in the management of sickle cell disease. We present two patients without sickle cell disease who underwent treatment with this novel agent to assist with chronic hypoxia and weaning of mechanical support.
1614. CT Scan Differences of Pulmonary TB According to Presence of Pleural Effusion.
Subpleural micronodules and interlobular septal thickening are common CT scan findings in TB pleural effusion. These CT scan features could help us differentiate between TB pleural effusion and nonTB empyema.
1615. The Economic Burden of Bronchiectasis: A Systematic Review.
作者: Jack M Roberts.;Vikas Goyal.;Sanjeewa Kularatna.;Anne B Chang.;Nitin Kapur.;James D Chalmers.;Pieter C Goeminne.;Francisco Hernandez.;Julie M Marchant.;Steven M McPhail.
来源: Chest. 2023年164卷6期1396-1421页
Bronchiectasis, a previously neglected condition, now has renewed research interest. There are a few systematic reviews that have reported on the economic and societal burden of bronchiectasis in adults, but none have reported on children. We undertook this systematic review to estimate the economic burden of bronchiectasis in children and adults.
1616. Microbiological Cure at Treatment Completion Is Associated With Longer Survival in Patients With Mycobacterium avium Complex Pulmonary Disease.
作者: Joong-Yub Kim.;JiWon Park.;Yunhee Choi.;Taek Soo Kim.;Nakwon Kwak.;Jae-Joon Yim.
来源: Chest. 2023年164卷5期1108-1114页
Morbidity and mortality from nontuberculous mycobacterial pulmonary disease (NTM-PD) are increasing. Mycobacterium avium complex (MAC) is the most common cause of NTM-PD. Microbiological outcomes are widely used as the primary end point of antimicrobial treatment, but their long-term impact on prognosis is uncertain.
1618. CT Imaging With Machine Learning for Predicting Progression to COPD in Individuals at Risk.
作者: Kalysta Makimoto.;James C Hogg.;Jean Bourbeau.;Wan C Tan.;Miranda Kirby.
来源: Chest. 2023年164卷5期1139-1149页
Identifying individuals at risk of progressing to COPD may allow for initiation of treatment to potentially slow the progression of the disease or the selection of subgroups for discovery of novel interventions.
1619. The Thoracic Research Evaluation and Treatment 2.0 Model: A Lung Cancer Prediction Model for Indeterminate Nodules Referred for Specialist Evaluation.
作者: Caroline M Godfrey.;Maren E Shipe.;Valerie F Welty.;Amelia W Maiga.;Melinda C Aldrich.;Chandler Montgomery.;Jerod Crockett.;Laszlo T Vaszar.;Shawn Regis.;James M Isbell.;Otis B Rickman.;Rhonda Pinkerman.;Eric S Lambright.;Jonathan C Nesbitt.;Fabien Maldonado.;Jeffrey D Blume.;Stephen A Deppen.;Eric L Grogan.
来源: Chest. 2023年164卷5期1305-1314页
Appropriate risk stratification of indeterminate pulmonary nodules (IPNs) is necessary to direct diagnostic evaluation. Currently available models were developed in populations with lower cancer prevalence than that seen in thoracic surgery and pulmonology clinics and usually do not allow for missing data. We updated and expanded the Thoracic Research Evaluation and Treatment (TREAT) model into a more generalized, robust approach for lung cancer prediction in patients referred for specialty evaluation.
1620. Improving Diagnosis of Pulmonary Mucormycosis: Leads From a Contemporary National Study of 114 Cases.
作者: Anne Coste.;Anne Conrad.;Raphaël Porcher.;Sylvain Poirée.;Pierre Peterlin.;Claire Defrance.;Valérie Letscher-Bru.;Florent Morio.;Thomas Gastinne.;Marie-Elisabeth Bougnoux.;Felipe Suarez.;Gilles Nevez.;Damien Dupont.;Florence Ader.;Carine Halfon-Domenech.;Sophie Ducastelle-Leprêtre.;Françoise Botterel.;Laurence Millon.;Gaelle Guillerm.;Séverine Ansart.;David Boutoille.;Marie-Pierre Ledoux.;Jean-Etienne Herbrecht.;Christine Robin.;Giovanna Melica.;François Danion.;Elodie Blanchard.;Olivier Paccoud.;Dea Garcia-Hermoso.;Olivier Lortholary.;Raoul Herbrecht.;Fanny Lanternier.; .
来源: Chest. 2023年164卷5期1097-1107页
Pulmonary mucormycosis (PM) is a life-threatening invasive mold infection. Diagnosis of mucormycosis is challenging and often delayed, resulting in higher mortality.
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