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141. Ventricular Arrhythmia and Cardiac Fibrosis in Endurance Experienced Athletes (VENTOUX).
作者: Wasim Javed.;Ioannis Botis.;Ze Min Goh.;Mubien Shabi.;Benjamin Brown.;Raluca Tomoaia.;Maryum Farooq.;Eylem Levelt.;Lee Graham.;John Gierula.;Peter Kellman.;John P Greenwood.;Sven Plein.;Peter P Swoboda.
来源: Circ Cardiovasc Imaging. 2025年18卷8期e018470页
Sudden cardiac death due to primary arrhythmia is a leading cause of mortality in athletes, predominantly affecting older male athletes. Myocardial fibrosis is strongly associated with arrhythmogenesis in nonischemic cardiomyopathy, but its clinical significance in asymptomatic endurance athletes is unknown. We aimed to investigate whether myocardial fibrosis on cardiovascular magnetic resonance in asymptomatic veteran male athletes was associated with incident ventricular arrhythmia on long-term implantable loop recorder.
143. Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences.
作者: Cameron Beeche.;Bingxin Zhao.;Hamed Tavolinejad.;Bianca Pourmussa.;Joonghyun Kim.;Jeffrey Duda.;James Gee.;Walter R Witschey.;Julio A Chirinos.; .
来源: Circulation. 2025年
Vascular aging is an important phenotype characterized by structural and geometric remodeling. Some individuals exhibit supernormal vascular aging, associated with improved cardiovascular outcomes; others experience early vascular aging, linked to adverse cardiovascular outcomes. The aorta is the artery that exhibits the most prominent age-related changes; however, the biological mechanisms underlying aortic aging, its genetic architecture, and its relationship with cardiovascular structure, function, and disease states remain poorly understood.
144. Cardiac Troponin C E135A Variant Impairs Myofilament Response to PKA Phosphorylation and Is Associated With Autosomal Dominant Dilated Cardiomyopathy With Diastolic Dysfunction.
作者: Maicon Landim-Vieira.;Robin M Perelli.;Michelle Rodriguez-Garcia.;Vivek P Jani.;Ronnie C Chastain.;Joshua H Lamar.;Ellen Mines.;Gwimoon Seo.;Aurelia Araujo Fernandes.;Bjorn Knollmann.;Michael P Carboni.;Stephen P Chelko.;Vitold E Galkin.;P Bryant Chase.;Jose Renato Pinto.;Andrew P Landstrom.
来源: Circ Genom Precis Med. 2025年18卷4期e004720页
Dilated cardiomyopathy (DCM) is a heart muscle disease in which the left ventricle is enlarged, resulting in systolic dysfunction. Pathogenic variants in genes encoding proteins involved in cardiac contractility, cytoskeleton structure, and Ca2+ handling have been associated with DCM. TNNC1 (cTnC [cardiac troponin C]) variants are implicated in DCM, hypertrophic, and restrictive cardiomyopathies. Unlike other sarcomere genes, most reports of TNNC1 variants lack segregation or pedigree data, partly because the majority of the variants described, to date, have been reported as de novo. Therefore, a critical need is warranted to further understand the mechanisms by which TNNC1 variants could impact myofilament function, especially in response to PKA (protein kinase A)-mediated phosphorylation as this posttranslational modification modulates sarcomere function in response to β-adrenergic stimulation.
145. Neurodevelopmental Outcomes in Early Adolescence: The Pediatric Heart Network Single Ventricle Reconstruction Trial.
作者: Thomas A Miller.;Binu Sharma.;Russell Gongwer.;Felicia L Trachtenberg.;Jane W Newburger.;Caren S Goldberg.;Kathryn E Gustafson.;J William Gaynor.;Jodie K Votava-Smith.;Linda M Lambert.;Renee Sananes.;Mary C Kral.;Rocky Tsang.;Kimberley P Heinrich.;James Cnota.;Amee Shah.;Dawn Ilardi.; .
来源: Circulation. 2025年
Neurodevelopmental and functional impairments are among the most consequential morbidities for survivors of hypoplastic left heart syndrome after staged single ventricle surgical palliation. The SVRIII trial (Long-Term Outcomes of Children With Hypoplastic Left Heart Syndrome and the Impact of Norwood Shunt Type) enrolled adolescents, who were randomized to different surgical shunt types at the time of Norwood procedure as neonates, for multifaceted in-person evaluation. This study reports their neurodevelopmental outcomes.
146. Long-Term Follow-Up in Severe Mitral Stenosis With Low Transmitral Diastolic Pressure Gradient: From MASTER Registry.
作者: Iksung Cho.;Dae-Young Kim.;Jinseob Kim.;Ha Jeong Lim.;Jiwon Seo.;Kyu Kim.;Seo-Yeon Gwak.;Hyun-Jung Lee.;Hee Jeong Lee.;Kyu-Yong Ko.;Chi Young Shim.;Jong-Won Ha.;Seonhwa Lee.;In-Cheol Kim.;Kang-Un Choi.;Jang-Won Son.;Joo Hee Park.;Geu-Ru Hong.;Jagat Narula.
来源: Circ Cardiovasc Imaging. 2025年e018124页
Long-term follow-up studies in severe mitral stenosis (MS) with low transmitral mean diastolic pressure gradient (MDPG) are not available. We evaluated the prognostic implications of severe MS with low MDPG in our MASTER (Multicenter Mitral Stenosis with Rheumatic Etiology) registry.
147. Assessing LV Contractility Identifies Populations With Preserved Ejection Fraction at Risk of Adverse Heart Failure Outcomes.
作者: Sam Straw.;Oliver I Brown.;Charlotte A Cole.;Judith E Lowry.;Marcella Conning-Rowland.;Stephe Kamalathasan.;Sushma Datla.;Maria F Paton.;Ruth Burgess.;Michael Drozd.;Thomas A Slater.;Samuel D Relton.;Eylem Levelt.;Klaus K Witte.;Mark T Kearney.;Richard M Cubbon.;John Gierula.
来源: Circ Cardiovasc Imaging. 2025年e018370页
Left ventricular ejection fraction (LVEF) is an essential tool for heart failure (HF) assessment but is limited by load dependence. Additional tools are needed to risk-stratify normal LVEF populations. We aimed to assess the prognostic value of systolic blood pressure-indexed left ventricular end-systolic volume ratio, or cardiac contractility index (CCI).
148. PIEZO1 Overexpression in Hereditary Hemorrhagic Telangiectasia Arteriovenous Malformations.
作者: Hyojin Park.;Sungwoon Lee.;Jessica Furtado.;Mark Robinson.;Richard J Antaya.;S Paul Oh.;Young-Kwon Hong.;Martin A Schwartz.;Lawrence H Young.;Anne Eichmann.
来源: Circulation. 2025年
Hereditary hemorrhagic telangiectasia is an inherited vascular disorder characterized by arteriovenous malformations (AVMs). Loss-of-function variations in activin receptor-like kinase 1 (ALK1) cause type 2 hereditary hemorrhagic telangiectasia, and Alk1 knockout mice develop AVMs, along with overactivation of vascular endothelial growth factor receptor 2/phosphoinositide 3-kinase/AKT signaling. The full spectrum of signaling alterations resulting from ALK1 variations remains unknown, and more effective and specific inhibitors to combat AVM formation in patients are needed.
149. Molecular Phenogroups in Heart Failure: Large-Scale Proteomics in a Population-Based Cohort.
作者: Carolina G Downie.;Joseph J Shearer.;Kayode O Kuku.;Suzette J Bielinski.;Jorge R Kizer.;Bruce M Psaty.;Jungnam Joo.;Véronique L Roger.
来源: Circ Genom Precis Med. 2025年18卷4期e004953页
Heart failure (HF) is a heterogeneous syndrome with high mortality. The need for a new taxonomy of HF is recognized; up to now, such phenomapping efforts have primarily used clinical data. Proteomics offers potential for more precise phenotypic identification and mechanistic insights. However, few phenomapping studies have used this approach, and all have focused on targeted cardiovascular proteomics panels and a restricted HF ejection fraction group.
150. Midterm Outcomes in a Pooled Cohort of Harmony Transcatheter Pulmonary Valve Recipients.
作者: Brian H Morray.;Matthew J Gillespie.;John P Cheatham.;Arash Salavitabar.;Lynn Peng.;Thomas K Jones.;Daniel S Levi.;Robert G Gray.;Jeremy Asnes.;Allison K Cabalka.;Kazuto Fujimoto.;Athar M Qureshi.;Lisa Bergersen.;Lee N Benson.;Daniel Haugan.;Doff B McElhinney.
来源: Circ Cardiovasc Interv. 2025年e015196页
The Harmony transcatheter pulmonary valve (TPV) is designed to treat severe pulmonary regurgitation in the native or surgically repaired right ventricular (RV) outflow tract. Early outcomes after TPV replacement with the Harmony valve have been positive, but longer-term data are limited.
151. Unique Role of Intracellular Perinuclear β1-Adrenergic Receptors in Defining Signaling Compartmentation and Pathological Cardiac Remodeling.
作者: Moriah Gildart Turcotte.;Anne-Maj Samuelsson.;Sofia M Possidento.;Jinliang Li.;Zhuyun Qin.;Michael S Kapiloff.;Kimberly L Dodge-Kafka.
来源: Circulation. 2025年
β-Adrenergic receptors (βARs) are prototypical G protein-coupled receptors that regulate contractility in the normal heart and pathological remodeling in disease. Canonical βAR signaling originates at the plasma membrane, but functional βARs have been localized to intracellular membranes such as the endosome, sarcoplasmic reticulum, Golgi, and nuclear envelope. The functional significance of these intracellular receptors remains unclear, including whether they regulate cellular processes distinct from those regulated by plasma membrane receptors and whether they can be independently targeted for therapeutic benefit.
153. Correction to: 2025 AHA/ACC Clinical Performance and Quality Measures for Patients With Chronic Coronary Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Performance Measures.
作者: Marlene S Williams.;Glenn N Levine.;Dinesh Kalra.;Anandita Agarwala.;Diana Baptiste.;Joaquin E Cigarroa.;Rebecca L Diekemper.;Marva V Foster.;Martha Gulati.;Timothy D Henry.;Dipti Itchhaporia.;Jennifer S Lawton.;L Kristin Newby.;Kelly C Rogers.;Krishan Soni.;Jacqueline E Tamis-Holland.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷7期e000141页 154. Efficacy and Safety of Edoxaban in Anticoagulant Therapy Early After Surgical Bioprosthetic Valve Replacement: A Randomized Clinical Trial.
作者: Chisato Izumi.;Masashi Amano.;Yusuke Yoshikawa.;Satsuki Fukushima.;Hitoshi Yaku.;Kiyoyuki Eishi.;Taichi Sakaguchi.;Nobuhisa Ohno.;Arudo Hiraoka.;Kenji Okada.;Yoshikatsu Saiki.;Takashi Miura.;Tatsuhiko Komiya.;Manabu Minami.;Haruko Yamamoto.;Katsuhiro Omae.; .
来源: Circ Cardiovasc Interv. 2025年18卷7期e015108页
Anticoagulant therapy with vitamin K antagonists is recommended in the current guidelines for 3 to 6 months following bioprosthetic valve replacement. However, in the era of direct oral anticoagulants, there is a paucity of evidence regarding the efficacy and safety of direct oral anticoagulants in this patient group.
157. Physical Activity and Incident Atrial Fibrillation in African Americans: The Jackson Heart Study.
作者: Jack Tiahnybik.;Marielle Siebert.;Daisuke Kamimura.;Wondwosen Yimer.;Yuan-I Min.;Kaustuv Bhattacharya.;James Floyd.;Yi Yang.;Susan R Heckbert.;Michael E Hall.;Adolfo Correa.;Takeki Suzuki.
来源: Circulation. 2025年152卷2期126-128页 158. The Promise and Peril of Learning Algorithms and Predictive Models in Clinical Decision Support: Be Careful What You Train For.
Continued growth in AI-enhanced clinical decision is expected. Representative populations for model training/validation are needed.
159. DNA Methylation Signatures of Cardiovascular Health Provide Insights Into Diseases.
作者: Madeleine Carbonneau.;Yi Li.;Yishu Qu.;Yinan Zheng.;Alexis C Wood.;Mengyao Wang.;Chunyu Liu.;Tianxiao Huan.;Roby Joehanes.;Xiuqing Guo.;Jie Yao.;Kent D Taylor.;Russell P Tracy.;Peter Durda.;Yongmei Liu.;W Craig Johnson.;Wendy S Post.;Tom Blackwell.;Jerome I Rotter.;Stephen S Rich.;Susan Redline.;Myriam Fornage.;Jun Wang.;Hongyan Ning.;Lifang Hou.;Donald Lloyd-Jones.;Kendra Ferrier.;Yuan-I Min.;April P Carson.;Laura M Raffield.;Alexander Teumer.;Hans J Grabe.;Henry Völzke.;Matthias Nauck.;Marcus Dörr.;Arce Domingo-Relloso.;Amanda Fretts.;Maria Tellez-Plaza.;Shelley A Cole.;Ana Navas-Acien.;Meng Wang.;Joanne M Murabito.;Nancy L Heard-Costa.;Brenton Prescott.;Vanessa Xanthakis.;Dariush Mozaffarian.;Daniel Levy.;Jiantao Ma.
来源: Circulation. 2025年152卷7期436-449页
The association of overall cardiovascular health (CVH) with changes in DNA methylation (DNAm) has not been well characterized.
160. Predicting Outcomes in Pediatric Intraluminal Pulmonary Vein Stenosis Using a Comprehensive Standardized Catheterization Assessment: A Prospective Study.
作者: Ryan Callahan.;Kimberlee Gauvreau.;Mirjam Keochakian.;Jesse J Esch.;Diego Porras.;Lisa Bergersen.;Rebecca Beroukhim.;Michael Farias.;David M Harrild.;Christina M Ireland.;Neha Kwatra.;Kathy J Jenkins.
来源: Circ Cardiovasc Interv. 2025年e015002页
Pediatric intraluminal pulmonary vein stenosis (PVS) occurs in a heterogeneous patient population but is unified by its cellular composition in affected pulmonary veins. Enhanced delineation of the hemodynamic and physiological vein consequences of PVS and its impact on vein lumen, vein pressure, wall structure, vein compliance, and wall shear stress has not been studied. The objective is to assess PVS characteristics using multimodal catheterization techniques (angiography, pulmonary vein pressure, intravascular ultrasound, balloon compliance testing, and wall shear stress calculation) and determine their association with vein outcomes.
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